Sina Tavakoli

Noninvasive PET Imaging of Pathologic VLA-4–Mediated Hyperadhesion in Sickle Cell Disease

Vanessa Shehu, Charles M. Laymon, Leticia Candra, Xiyi Wang et autres

Abstract Background Vaso-occlusive episodes (VOE) pose a significant health burden on patients with sickle cell disease (SCD) and remain the leading cause of emergency department visits due to SCD (Jang et al., Journal of Translational Medicine, 2021). In the vascular pathophysiology underlying …

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Hydroxyurea reduces hyper-adhesion measured by a VLA-4 targeting PET tracer in sickle transgenic Townes mice

Nishi Yadav, Qin Zhu, LYNDA L. LITTLE-IHRIG, Joseph D. Latoche et autres

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The Significance of Fibrosis Patterns in Combined Pulmonary Fibrosis and Emphysema: Insights and Challenges

Sina Tavakoli, Zehavit E. Kirshenboim

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Hydroxyurea Reduces Hyperadhesion Measured by a VLA-4 Targeting PET Tracer in Transgenic Sickle Mice

Nishi Yadav, Kanishka Sikligar, Olivia Heyne, Mikayla Rodgers et autres

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Development and expression of a factor X-derived recombinant protein for ELISA-based detection of Emicizumab

Sina Tavakoli, Shohreh Zare Karizi, Jafar Amani

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Chemokine-Like Receptor 1 Targeted Positron Emission Tomography as a Tool for Tracking Dynamics of Monocyte-Derived Macrophages in an Experimental Model of Progressive Pulmonary Fibrosis

JONATHAN W. SAID, Philip Z. Mannes, Sanskriti Shrivastava, Joseph D. Latoche et autres

Abstract Background: The recruitment and accumulation of monocyte-derived macrophages (MDM) are increasingly recognized as key drivers of pulmonary fibrosis. Non-invasive monitoring of MDM accumulation offers a precision medicine approach to assess the inflammatory component of fibrotic lung diseases, allowing for personalized treatment …

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Preoperative Imaging of the Thoracic Aorta

Zehavit E. Kirshenboim, Ömer Önder, Emrah Duman, Azza Mohamed Elgendy et autres

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Aberrant mitochondrial DNA synthesis in macrophages exacerbates inflammation and atherosclerosis

Niranjana Natarajan, Jonathan Florentin, Ebin Johny, Hanxi Xiao et autres

There is a large body of evidence that cellular metabolism governs inflammation, and that inflammation contributes to the progression of atherosclerosis. However, whether mitochondrial DNA synthesis affects macrophage function and atherosclerosis pathology is not fully understood. Here we show, by transcriptomic analyzes …

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Noninvasive assessment of the lung inflammation-fibrosis axis by targeted imaging of CMKLR1

Philip Z. Mannes, Taylor Sterling Adams, Samaneh Farsijani, Clayton E. Barnes et autres

Precision management of fibrotic lung diseases is challenging due to their diverse clinical trajectories and lack of reliable biomarkers for risk stratification and therapeutic monitoring. Here, we validated the accuracy of CMKLR1 as an imaging biomarker of the lung inflammation-fibrosis axis. By …

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Dietary intake and glutamine-serine metabolism control pathologic vascular stiffness

Nesrine Rachedi, Ying Tang, Yi-Yin Tai, Jingsi Zhao et autres

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Imaging Cardiac and Vascular Inflammation

Sina Tavakoli, Mehran M. Sadeghi

Abstract Molecular imaging is an emerging approach that allows clinicians to noninvasively obtain quantitative information about the inflammatory processes that are involved in the pathogenesis of cardiovascular diseases. Therefore, it can serve as a precision medicine tool for early diagnosis and risk …

Imaging Cardiac and Vascular Inflammation

Sina Tavakoli, Mehran M. Sadeghi

Abstract Molecular imaging is an emerging approach that allows clinicians to noninvasively obtain quantitative information about the inflammatory processes that are involved in the pathogenesis of cardiovascular diseases. Therefore, it can serve as a precision medicine tool for early diagnosis and risk …