Michela Ghersetti

Direct‐acting antiviral agents for hepatitis C virus‐mixed cryoglobulinaemia: dissociated virological and haematological responses

Gabriele Pozzato, Cesare Mazzaro, Marina Artemova, Dzhamal T. Abdurakhmanov et autres

The hepatitis C virus-positive (HCV+) mixed cryoglobulinaemia (MC) is associated with haematological alterations such as monoclonal B-cell lymphocytosis or non-Hodgkin lymphomas (NHLs). Antiviral therapy for MC, based on interferon and ribavirin, has been shown to be able to eliminate the viral replication …

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Acquired Haemophilia A. Which is the best therapeutic choice in older adults? Single center study of 4 cases

Enrico Mauro, E. Garlatti Costa, A. Zanier, Martina Maset et autres

Acquired haemophilia A (AHA) is a rare bleeding disorder due to autoantibodies directed against coagulation factor VIII. The treatment is based on recombinant activated factor VII and activated prothrombin complex concentrate. However, mainly in older patients, severe thrombotic complications have been reported. …

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Long-term effects of the new direct antiviral agents (DAAs) therapy for HCV-related mixed cryoglobulinaemia without renal involvement: a multicentre open-label study.

Cesare Mazzaro, Luigino Dal Maso, Luca Quartuccio, Michela Ghersetti et autres

OBJECTIVES: To investigate the long-term effects and safety of new direct anti-viral agents (DAAs) in patients with hepatitis C virus (HCV)-related mixed cryoglobulinaemia (MC) without renal involvement. METHODS: The study enrolled 22 consecutive patients, 19 received sofosbuvir-based regimen and three patients received …

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Survival and Prognostic Factors in Mixed Cryoglobulinemia: Data from 246 Cases

Cesare Mazzaro, Luigino Dal Maso, Endri Mauro, Valter Gattei et autres

Introduction: The clinical and therapeutic management of mixed cryoglobulinemia (MC) remains a subject of controversy. In addition, most studies have not recorded the long-term follow-up and the outcome of these cases. Material and Methods: We enrolled 246 patients affected by MC who …

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Direct acting antiviral (DAA) therapy of HCV, effects on the cryoglobulinemic vasculitis: A multi center open label study

Endri Mauro, Luca Quartuccio, Michela Ghersetti, Marco Lenzi et autres

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Real life of DAAs (direct antiviral agents) for HCV infection in Friuli Venezia Giulia: Who, why, what, how did we treat?

Flora Masutti, E. Garlatti Costa, Ivo Maria Crosato, Giorgio Soardo et autres

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HCV-related liver and lymphoproliferative diseases: association with polymorphisms of IL28B and TLR2

Vallì De Re, Mariangela De Zorzi, Laura Caggiari, Gianfranco Lauletta et autres

// Valli De Re 1,* , Mariangela De Zorzi 1,* , Laura Caggiari 1 , Gianfranco Lauletta 2 , Maria Lina Tornesello 3 , Elisa Fognani 4 , Marta Miorin 5 , Vito Racanelli 6 , Luca Quartuccio 7 , Laura Gragnani …

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Fever and erythema: exclude all and then… think of Still’s disease!

Marta Maset, Elena Garlatti Costa, Giorgio Siro Carniello, Silvia Grazioli et autres

Adult-onset Still’s disease (AOSD) is a rare disease. Diagnosis of Still’s disease is often difficult to achieve. Herein, we describe our diagnostic approach in a case report regarding an adult patient who presented with fever, erythema, lymphadenopathy and arthralgia.

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Prolonged and biphasic acute hepatitis A in hepatitis B virus carrier

Elena Garlatti Costa, Michela Ghersetti, Silvia Grazioli, Pietro Casarin

Acute hepatitis A is generally a self-limited disease in healthy subjects within few weeks, but an uncommon type of prolonged and biphasic acute course of hepatitis A infection has been also described. This type of presentation is observed in about 6-10% of …

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Efficacy of dual therapy in patients >65 years old with alanine transaminase flare during chronic hepatitis C genotype 2

Elena Garlatti Costa, Michela Ghersetti, Silvia Grazioli, Pietro Casarin

Hepatitis C virus (HCV)-related chronic hepatitis is characterized by different clinical outcomes as well as by distinct biochemical and virological patterns. According to guidelines concerning dual therapy, high rates of sustained virological response (or HCV-RNA undetectable 24 weeks after the end of …

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Management of infectious mixed cryoglobulinemia: Clinical outcome of 246 patients

Ezequiel Mauro, Luigino Dal Maso, Anna Ermacora, Pietro Bulian et autres

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Alcohol and HCV Chronic Infection Are Risk Cofactors of Type 2 Diabetes Mellitus for Hepatocellular Carcinoma in Italy

Massimiliano Balbi, Valter Donadon, Michela Ghersetti, Silvia Grazioli et autres

Type 2 diabetes mellitus (DM2) has been associated with hepatocellular carcinoma (HCC) development. To study this relationship, we enrolled 465 HCC patients compared with 618 Cirrhotic cases and 490 Controls. The prevalence of DM2 is significantly higher in HCC patients with an …