Filippo Massa

Inhibition of eIF5A hypusination improves pancreatic islet transplantation outcomes by promoting ischemia tolerance

Hajar Ouahmi, Filippo Massa, Elisa Allart, Marc Cougnon et autres

Abstract Pancreatic islet transplantation provides substantial benefits for individuals with Type 1 Diabetes (T1D). However, the low yield of the procedure limits its therapeutic potential, as multiple injections from different donors are needed to provide sufficient islets for a single recipient. Many …

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The eIF5A hypusination inhibitor GC7 improves tolerance of pancreatic beta cells to ischemia/reperfusion

Hajar Ouahmi, Filippo Massa, Marc Cougnon, Isabelle Rubera et autres

Treatment of rodent beta cell line with GC7, an inhibitor of eIF5A hypusination, reversibly slows down mitochondrial activity and shifts the cells' energy metabolism toward anaerobic glycolysis. As a result, GC7 treatment transiently inhibits ATP production and insulin secretion in response to …

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Qualité de l’air et femmes enceintes : sensibiliser, oui mais comment ? Regards croisés des femmes enceintes et professionnels de santé

R. Collomp, P. Manrogiu, Morgane Brobst, T. Collomp et autres

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Reviewer #1 (Public Review): MAFB drives differentiation by permitting WT1 binding to podocyte specific promoters

Filippo Massa, Fariba Jian-Motamedi, Marijus Šerys, Amélie Tison et autres

Podocytes are highly specialized cells, but their chromatin status and the precise molecular events leading to their differentiation remain poorly defined. Here we used ChIP-Seq analysis for H3K4me3, H3K4me1 and H3K27me3 to establish the histone methylation map in adult mouse podocytes. Our …

MAFB drives differentiation by permitting WT1 binding to podocyte specific promoters

Filippo Massa, Fariba Jian-Motamedi, Marijus Šerys, Amélie Tison et autres

Abstract Podocytes are highly specialized cells, but their chromatin status and the precise molecular events leading to their differentiation remain poorly defined. Here we used ChIP-Seq analysis for H3K4me3, H3K4me1 and H3K27me3 to establish the histone methylation map in adult mouse podocytes. …

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Reviewer #2 (Public Review): MAFB drives differentiation by permitting WT1 binding to podocyte specific promoters

Filippo Massa, Fariba Jian-Motamedi, Marijus Šerys, Amélie Tison et autres

Podocytes are highly specialized cells, but their chromatin status and the precise molecular events leading to their differentiation remain poorly defined. Here we used ChIP-Seq analysis for H3K4me3, H3K4me1 and H3K27me3 to establish the histone methylation map in adult mouse podocytes. Our …

MAFB drives differentiation by permitting WT1 binding to podocyte specific promoters

Filippo Massa, Fariba Jian-Motamedi, Marijus Šerys, Amélie Tison et autres

Abstract Podocytes are highly specialized cells, but their chromatin status and the precise molecular events leading to their differentiation remain poorly defined. Here we used ChIP-Seq analysis for H3K4me3, H3K4me1 and H3K27me3 to establish the histone methylation map in adult mouse podocytes. …

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Author Response: MAFB drives differentiation by permitting WT1 binding to podocyte specific promoters

Filippo Massa, Fariba Jian-Motamedi, Marijus Šerys, Amélie Tison et autres

Podocytes are highly specialized cells, but their chromatin status and the precise molecular events leading to their differentiation remain poorly defined. Here we used ChIP-Seq analysis for H3K4me3, H3K4me1 and H3K27me3 to establish the histone methylation map in adult mouse podocytes. Our …

fr, de (code pays fourni par la source)

MAFB drives differentiation by permitting WT1 binding to podocyte specific promoters

Filippo Massa, Fariba Jian-Motamedi, Marijus Šerys, Amélie Tison et autres

Abstract Podocytes are highly specialized cells, but their chromatin status and the precise molecular events leading to their differentiation remain poorly defined. Here we used ChIP-Seq analysis for H3K4me3, H3K4me1 and H3K27me3 to establish the histone methylation map in adult mouse podocytes. …

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Low T Cell Responsiveness in the Early Phase of COVID-19 Associates with Progression to Severe Pneumonia in Kidney Transplant Recipients

Marion Crémoni, Sébastien Cuozzo, Emanuela Martinuzzi, Susana Barbosa et autres

Kidney transplant (KT) recipients are at increased risk of developing severe forms of COVID-19. Little is known about the immunological mechanisms underlying disease severity in these patients receiving T-cell targeting immunosuppressive drugs. We investigated the relationship between T cell responsiveness at the …

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Overcoming barriers to widespread use of CAR‐Treg therapy in organ transplant recipients

Marion Crémoni, Filippo Massa, Antoine Sicard

Preventing allograft rejection has been the main challenge of transplantation medicine since the discovery of immune responses against foreign HLA molecules in the mid-20th century. Prevention of rejection currently relies on immunosuppressive drugs, which lack antigen specificity and therefore increase the risk …

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Safety and cross-variant immunogenicity of a three-dose COVID-19 mRNA vaccine regimen in kidney transplant recipients

Filippo Massa, Marion Crémoni, Alexandre Olivier Gérard, Hanen Grabsi et autres

BACKGROUND: The immunogenicity of a two-dose mRNA COVID-19 vaccine regimen is low in kidney transplant (KT) recipients. Here, we provide a thorough assessment of the immunogenicity of a three-dose COVID-19 vaccine regimen in this population. METHODS: We performed a prospective longitudinal study …

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