Chengchuang Zhan

Hydrogen alleviates right ventricular hypertrophy by inhibiting ferroptosis via restoration of the Nrf2/HO-1 signaling pathway

Juncai Bai, Hongxiao Yang, Chengchuang Zhan, Luqi Zhao et autres

BACKGROUND Right ventricular hypertrophy (RVH) occurs because of volume or pressure overload within the right ventricular (RV) system. RVH is associated with complex pathological changes, including myocardial cell injury, apoptosis, myocardial fibrosis, neuroendocrine disturbances, and abnormal water and liquid metabolism. Ferroptosis, a …

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Case report: Persistent ST-segment elevation due to cardiac metastasis from lung cancer

Jiawei Zhou, Chengchuang Zhan, Jing Zhou, Chao Wei et autres

Patients with secondary cardiac cancer occasionally show ST segment elevation that mimics acute coronary syndrome despite the absence of coronary artery occlusion. We herein describe a rare case of secondary cardiac cancer that presented with ST-segment elevation. An 82-year-old Chinese man was …

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Vericiguat reduces electrical and structural remodeling in a rabbit model of atrial fibrillation

Qi Lou, Luyifei Li, Guangzhong Liu, Tiankai Li et autres

Purpose: The molecular etiology of atrial fibrillation (AF) and its treatment are poorly understood. AF involves both electrical and structural features. Vericiguat can ameliorate cardiac remodeling in heart failure. The effects of vericiguat on AF, however, are unclear. Here, the actions of …

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Hydrogen Attenuates Thyroid Hormone-Induced Cardiac Hypertrophy in Rats by regulating angiotensin II type 1 receptor and NADPH oxidase 2 mediated oxidative stress

Hongxiao Yang, Juncai Bai, Chengchuang Zhan, Shuang Liu et autres

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[Retracted] Effects of Sacubitril/Valsartan on the Expression of CaMKII/Cav1.2 in Atrial Fibrillation Stimulation Rabbit Model

Qi Lou, Luyifei Li, Guangzhong Liu, Chengchuang Zhan et autres

Background and Objective . Atrial fibrillation (AF) is linked to high morbidity and death rates throughout the world due to limited therapeutic options and thus presents a major challenge to the developed and developing countries. In this study, we aim to investigate …

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Detection of circRNA Biomarker for Acute Myocardial Infarction Based on System Biological Analysis of RNA Expression

Wen Yang, Li Sun, Xun Cao, Luyifei Li et autres

Acute myocardial infarction (AMI) is myocardial necrosis caused by the persistent interruption of myocardial blood supply, which has high incidence rate and high mortality in middle-aged and elderly people in the worldwide. Biomarkers play an important role in the early diagnosis and …

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Tranilast prevents doxorubicin-induced myocardial hypertrophy and angiotensin II synthesis in rats

Chengchuang Zhan, Nan Bai, Min Zheng, Yanyan Wang et autres

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Sacubitril/valsartan attenuates atrial electrical and structural remodelling in a rabbit model of atrial fibrillation

Luyifei Li, Qi Lou, Guangzhong Liu, Jiachen Lv et autres

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Rotenone and 3-bromopyruvate toxicity impacts electrical and structural cardiac remodeling in rats

Chengchuang Zhan, Guangzhong Liu, Jianqiang Li, Guangnan Li et autres

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Chronic B-Type Natriuretic Peptide Therapy Prevents Atrial Electrical Remodeling in a Rabbit Model of Atrial Fibrillation

Hongyan Zhao, Tiankai Li, Guangzhong Liu, Li Zhang et autres

Background: Atrial fibrillation (AF) is an important and growing clinical problem. Current pharmacological treatments are unsatisfactory. Electrical remodeling has been identified as one of the principal pathophysiological mechanisms that promote AF, but there are no effective therapies to prevent or correct electrical …

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Fenofibrate inhibits atrial metabolic remodelling in atrial fibrillation through PPAR‐α/sirtuin 1/PGC‐1α pathway

Guangzhong Liu, Tingting Hou, Yue Yuan, Pengzhou Hang et autres

BACKGROUND AND PURPOSE: Atrial metabolic remodelling is critical for the process of atrial fibrillation (AF). The PPAR-α/sirtuin 1 /PPAR co-activator α (PGC-1α) pathway plays an important role in maintaining energy metabolism. However, the effect of the PPAR-α agonist fenofibrate on AF is …

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[Comparative study on hemolytic toxicity of trifluoroacetoprimaquine and primaquine in rabbits].

Xuan Shi, Chengchuang Zhan, Ha S, J Yiao

5-trifluoroacetoprimaquine (M8506) exhibited high effect on tissue schizont of P. cynomolgi and low toxicity in mice, rats and dogs as compared with primaquine (PQ) according to our previous studies. In order to determine their hemolytic toxicity, we dosed rabbits with M8506 and …

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