2020
article
OpenAlex
Andres A. Gonzalez, Brian Droker, Eric S. Kim, Pooja Parikh
PURPOSE: Intraoperative neurophysiological monitoring has been well documented as an adjunctive technique that significantly decreases the risk of developing inadvertent sensory and motor deficits during cranial and spine surgeries. The ability to detect neurologic problems intraoperatively depends largely on accurately identifying changes …
us
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Accès ouvert
2020
article
OpenAlex
Renato Mantegazza, Gil I. Wolfe, Srikanth Muppidi, Heinz Wiendl et autres
OBJECTIVE: To evaluate whether eculizumab helps patients with anti-acetylcholine receptor-positive (AChR+) refractory generalized myasthenia gravis (gMG) achieve the Myasthenia Gravis Foundation of America (MGFA) post-intervention status of minimal manifestations (MM), we assessed patients' status throughout REGAIN (Safety and Efficacy of Eculizumab in …
us, it, de
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Accès ouvert
2020
article
OpenAlex
Saiju Jacob, Hiroyuki Murai, Kimiaki Utsugisawa, Richard J. Nowak et autres
Background: In the phase III eculizumab for refractory generalized myasthenia gravis REGAIN study [ClinicalTrials.gov identifier: NCT01997229] and its open-label extension (OLE) [ClinicalTrials.gov identifier: NCT02301624], patients with treatment-refractory antiacetylcholine receptor antibody-positive generalized myasthenia gravis had clinically meaningful improvements with eculizumab versus placebo. This …
gb, jp, us, de
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Accès ouvert
2019
article
OpenAlex
Hiroyuki Murai, Akiyuki Uzawa, Yasushi Suzuki, Tomihiro Imai et autres
The terminal complement inhibitor eculizumab was shown to improve myasthenia gravis-related symptoms in the 26-week, phase 3, randomized, double-blind, placebo-controlled REGAIN study (NCT01997229). In this 52-week sub-analysis of the open-label extension of REGAIN (NCT02301624), eculizumab's efficacy and safety were assessed in 11 …
jp, us
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Accès ouvert
2019
article
OpenAlex
Henning Andersen, Renato Mantegazza, Jing Jing Wang, Fanny O’Brien et autres
PURPOSE: To evaluate the effect of eculizumab on perceived fatigue in patients with anti-acetylcholine receptor antibody-positive, refractory, generalized myasthenia gravis (MG) using the Quality of Life in Neurological Disorders (Neuro-QOL) Fatigue subscale, and to evaluate correlations between improvements in Neuro-QOL Fatigue and …
dk, it, us
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2017
article
OpenAlex
James F. Howard, Kimiaki Utsugisawa, Michael Benatar, Hiroyuki Murai et autres
us, jp, es, gb, dk, it
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2015
article
OpenAlex
Brian Droker, Emmanuelle Tiongson, Quyen Luc, Kiarash Sadrieh et autres
Background: Enterovirus D68 has been associated with pediatric flaccid paralysis. Methods/Design: Description of the EMG/NCV findings in two cases of sudden onset paralysis in 2 children; one confirmed Enterovirus D68 positive. Case #1: A 6 y.o. typically developing girl presented after one …
us
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2015
article
OpenAlex
Brian Droker, Parastou Shilian, Andrés González‐Mandly
Objective: To evaluate the current rates of obtaining SEP and MEP baselines. Background: Intraoperative monitoring (IOM) has been documented as an adjunctive technique used to minimize neurologic deficit during brain and spinal surgeries. IOM is predicated on the patient acting as an …
us
(code pays fourni par la source)
2015
article
OpenAlex
Brian Droker, Parastou Shilian, Andrés González‐Mandly
Objective: To evaluate the current rates of obtaining SEP and MEP baselines. Background: Intraoperative monitoring (IOM) has been documented as an adjunctive technique used to minimize neurologic deficit during brain and spinal surgeries. IOM is predicated on the patient acting as an …
us
(code pays fourni par la source)