Francesco Cavagnini

Metyrapone-associated improvements in health-related quality of life in Cushing's syndrome

Emese Mezősi, Lynnette K. Nieman, Carla Scaroni, Marco Boscaro et autres

OBJECTIVE: This analysis describes the evolution of health-related quality of life (HRQoL) over 36 weeks of metyrapone treatment in the PROMPT study, identifying patterns of early, delayed improvement, or persistence using item-level resolution. DESIGN AND METHODS: Longitudinal analysis of patient-reported outcomes from …

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Progression of acromegalic joint and psychological complications according to sex, treatments, and disease control

Biagio Cangiano, Matteo Corbetta, Caterina Premoli, Davide Soranna et autres

BACKGROUND: Articular and psychological complications of acromegaly are known to impair patients' quality of life (QoL). This multicenter prospective observational study aimed to (1) identify clinical predictors of the progression of these complications, (2) evaluate their progression in relation to disease activity, …

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Prospective study of metyrapone in endogenous Cushing's syndrome (PROMPT)

Lynnette K. Nieman, Marco Boscaro, Carla Scaroni, Timo Deutschbein et autres

OBJECTIVE: We evaluated the safety and efficacy of metyrapone treatment for Cushing's syndrome (CS). DESIGN: International, prospective, single-arm, open-label study. METHODS: Fifty adults with endogenous CS (either unsuitable for or uncontrolled after surgery) and 3 urinary free cortisol (UFC) concentrations each ≥1.5-fold …

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High prevalence of venous thrombotic events in Cushing's syndrome: data from ERCUSYN and details in relation to surgery

Kristina Isand, Richard A. Feelders, Thierry Brue, Miklós Tóth et autres

OBJECTIVE: The aim of this study was to evaluate the prevalence of venous thromboembolism (VTE) in patients included in the European Registry on Cushing's syndrome (ERCUSYN), compare their clinical characteristics with those who did not develop VTE and identify risk factors for …

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Cushing's syndrome in the elderly: data from the European Registry on Cushing's syndrome

Vincent Amodru, Amandine Ferrière, Antoine Tabarin, Frédéric Castinetti et autres

OBJECTIVE: To evaluate whether age-related differences exist in clinical characteristics, diagnostic approach, and management strategies in patients with Cushing's syndrome (CS) included in the European Registry on Cushing's Syndrome (ERCUSYN). DESIGN: Cohort study. METHODS: We analyzed 1791 patients with CS, of whom …

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Psychological complications in patients with acromegaly: relationships with sex, arthropathy, and quality of life

Biagio Cangiano, Emanuele Maria Giusti, Caterina Premoli, Davide Soranna et autres

PURPOSE: Current treatment of acromegaly restores a normal life expectancy in most cases. So, the study of persistent complications affecting patients' quality of life (QoL) is of paramount importance, especially motor disability and depression. In a large cohort of acromegalic patients we …

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Metyrapone treatment in endogenous Cushings syndrome. Long term efficacy and safety results of the extension of the phase III/IV study PROMPT

Lynnette K. Nieman, Marco Boscaro, Scaroni Carla, Timo Deutschbein et autres

Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | ISSN 1479-6848 (online)

Metyrapone Treatment in Endogenous Cushing’s Syndrome: Results at Week 12 From PROMPT, a Prospective International Multicenter, Open-Label, Phase III/IV Study

Lynnette K. Nieman, Marco Boscaro, Carla Scaroni, Timo Deutschbein et autres

Abstract Background: Metyrapone is a steroidogenesis inhibitor approved in Europe for the treatment of endogenous Cushing’s syndrome (CS) based on observational retrospective studies published over more than 50 years. We present data from the first prospective study designed to confirm metyrapone efficacy …

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Metyrapone treatment in endogenous Cushing’s syndrome. Results from a prospective multicenter, open-label, phase III/IV study: Prompt

Lynnette K. Nieman, Marco Boscaro, Scaroni Carla, Timo Deutschbein et autres

Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | ISSN 1479-6848 (online)

INTRODUZIONE AL CONVEGNO

Francesco Cavagnini, Luciano Martini

Non disponibile.

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IL CONTROLLO NEUROENDOCRINO DEL COMPORTAMENTO ALIMENTARE

Francesco Cavagnini

Appetite is regulated by a complex system of central and peripheral signals that interact in order to modulate eating behavior according the individual needs, i.e. the fasting or fed condition and the general nutritional status. Peripheral regulation includes adiposity signals and satiety …

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IL MUSICOLOGO

Francesco Cavagnini

Luciano Martini loved the music, of a love that entered directly into the category of passion. Thanks to the ability to read the music and a wide culture extended to other forms of art, he could get from the music maximum enjoyment. …

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