Gabrielle H. Cannon

Latent Regulatory Programs Generate Synthetic T Cell States with Enhanced Therapeutic Potential

Pratt Brandon, Genevieve N Mullins, Nolan J. Brown, William David Green et autres

Abstract Transcription factors (TFs) govern cell fate through coordinated gene-regulatory networks, yet the full potential of these networks to generate non-native, therapeutically advantageous cell states in vivo remains largely unexplored. We hypothesized that systematic gain-of-function (GOF) overexpression of TFs in CD8⁺ T …

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Liver single-nucleus multiome profiling reveals cell-type mechanisms for cardiometabolic traits

Abdalla A Alkhawaja, Kevin W. Currin, Hannah J. Perrin, Swarooparani Vadlamudi et autres

The liver is a central regulator of cardiometabolic physiology, coordinating processes such as lipid and glucose metabolism, protein synthesis, and detoxification. Genome-wide association studies (GWASs) have identified hundreds of genetic variants associated with cardiometabolic traits, yet their molecular mechanisms in liver cell …

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Liver single-nucleus multiome profiling reveals cell-type mechanisms for cardiometabolic traits

Abdalla A Alkhawaja, Kevin W. Currin, Hannah J. Perrin, Swarooparani Vadlamudi et autres

Abstract The liver is a central regulator of cardiometabolic physiology, coordinating processes such as lipid and glucose metabolism, protein synthesis, and detoxification. Genome-wide association studies (GWAS) have identified hundreds of genetic variants associated with cardiometabolic traits, yet their molecular mechanisms in liver …

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Effects of endometrial embryokines on the preimplantation bovine embryo to create a gene expression signature consistent with a high competence phenotype

Mariângela Bueno Cordeiro Maldonado, María Belén Rabaglino, Gabrielle H. Cannon, Peter J. Hansen

Optimal embryonic development depends upon cell-signaling molecules released by the maternal reproductive tract called embryokines. The identity of specific embryokines that enhance the competence of the embryo for sustained survival is largely lacking. The current objective was to evaluate the effects of …

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Ret deficiency decreases neural crest progenitor proliferation and restricts fate potential during enteric nervous system development

Elizabeth Vincent, Sumantra Chatterjee, Gabrielle H. Cannon, Dallas R. Auer et autres

The receptor tyrosine kinase RET plays a critical role in the fate specification of enteric neural crest–derived cells (ENCDCs) during enteric nervous system (ENS) development. RET loss of function (LoF) is associated with Hirschsprung disease (HSCR), which is marked by aganglionosis of …

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Ret loss-of-function decreases neural crest progenitor proliferation and restricts developmental fate potential during enteric nervous system development

Elizabeth Vincent, Sumantra Chatterjee, Gabrielle H. Cannon, Dallas R. Auer et autres

Abstract The receptor tyrosine kinase gene RET plays a critical role in the fate specification of enteric neural crest-derived cells (ENCDCs) during enteric nervous system (ENS) development. Pathogenic RET loss of function (LoF) alleles are associated with Hirschsprung disease (HSCR), which is …

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Precocious neuronal differentiation and disrupted oxygen responses in Kabuki syndrome

Giovanni A. Carosso, Leandros Boukas, Jonathan J. Augustin, Briana L. Winer et autres

Chromatin modifiers act to coordinate gene expression changes critical to neuronal differentiation from neural stem/progenitor cells (NSPCs). Lysine-specific methyltransferase 2D (KMT2D) encodes a histone methyltransferase that promotes transcriptional activation and is frequently mutated in cancers and in the majority (>70%) of patients …

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Single-Cell RNA-Seq Analysis of Retinal Development Identifies NFI Factors as Regulating Mitotic Exit and Late-Born Cell Specification

Brian S. Clark, Genevieve Stein-O’Brien, Fion Shiau, Gabrielle H. Cannon et autres

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Precocious neuronal differentiation and disrupted oxygen responses in Kabuki syndrome

Giovanni A. Carosso, Leandros Boukas, Jonathan J. Augustin, Ha Nam Nguyen et autres

Abstract Chromatin modifiers act to coordinate gene expression changes critical to neuronal differentiation from neural stem/progenitor cells (NSPCs). Lysine-specific methyltransferase 2D (KMT2D) encodes a histone methyltransferase that promotes transcriptional activation, and is frequently mutated in cancers and in the majority (>70%) of …

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Comprehensive analysis of retinal development at single cell resolution identifies NFI factors as essential for mitotic exit and specification of late-born cells

Brian S. Clark, Genevieve Stein-O’Brien, Fion Shiau, Gabrielle H. Cannon et autres

SUMMARY Precise temporal control of gene expression in neuronal progenitors is necessary for correct regulation of neurogenesis and cell fate specification. However, the extensive cellular heterogeneity of the developing CNS has posed a major obstacle to identifying the gene regulatory networks that …

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Single-Cell RNA-Seq of Mouse Dopaminergic Neurons Informs Candidate Gene Selection for Sporadic Parkinson Disease

Paul W. Hook, Sarah A. McClymont, Gabrielle H. Cannon, William Law et autres

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Variation in Activity State, Axonal Projection, and Position Define the Transcriptional Identity of Individual Neocortical Projection Neurons

Maxime Chevée, Johanna D. Robertson, Gabrielle H. Cannon, Solange P. Brown et autres

Single-cell RNA sequencing has generated catalogs of transcriptionally defined neuronal subtypes of the brain. However, the cellular processes that contribute to neuronal subtype specification and transcriptional heterogeneity remain unclear. By comparing the gene expression profiles of single layer 6 corticothalamic neurons in …

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