Discovery of novel cyclopentane carboxylic acids as potent and selective inhibitors of NaV1.7
Shaoyi Sun, Sultan Chowdhury, Ivan Hemeon, Abid Hasan et autres
0 citationsBioorganic & Medicinal Chemistry Letters
Thilo Focken
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32Publications signalées
1118Citations signalées
1Affiliations récentes
Institutions déclarées
Domaines associés
Ion channel regulation and functionNeuroscience and Neuropharmacology ResearchSynthetic Organic Chemistry MethodsAsymmetric Synthesis and CatalysisAsymmetric Hydrogenation and Catalysis
Publications récentes
The contribution of NaV1.6 to the efficacy of voltage‐gated sodium channel inhibitors in wild type and NaV1.6 gain‐of‐function (GOF) mouse seizure control
J. P. Johnson, Thilo Focken, Parisa Karimi Tari, Céline Dubé et autres
9 citationsBritish Journal of Pharmacology
Molecular Pharmacology of Selective Na V 1.6 and Dual Na V 1.6/Na V 1.2 Channel Inhibitors that Suppress Excitatory Neuronal Activity Ex Vivo
Samuel J. Goodchild, Noah Gregory Shuart, Aaron D. Williams, Wenlei Ye et autres
31 citationsACS Chemical Neuroscience
Na V 1.6 inhibition drives the efficacy of voltage-gated sodium channel inhibitors to prevent electrically induced seizures in both wild type and Scn8a N1768D/+ gain-of-function mice
J. P. Johnson, Thilo Focken, Parisa Karimi Tari, Céline Dubé et autres
2 citationsbioRxiv (Cold Spring Harbor Laboratory)
Molecular pharmacology of selective Na v 1.6 and dual Na v 1.6 and Na v 1.2 channel inhibitors that suppress excitatory neuronal activity ex vivo
Samuel J. Goodchild, Noah Gregory Shuart, Aaron D. Williams, Wenlei Ye et autres
1 citationbioRxiv (Cold Spring Harbor Laboratory)
Author response: NBI-921352, a first-in-class, NaV1.6 selective, sodium channel inhibitor that prevents seizures in Scn8a gain-of-function mice, and wild-type mice and rats
J. P. Johnson, Thilo Focken, Kuldip Khakh, Parisa Karimi Tari et autres
0 citations
NBI-921352, a First-in-Class, Na V 1.6 Selective, Sodium Channel Inhibitor That Prevents Seizures in Scn8a Gain-of-Function Mice, and Wild-Type Mice and Rats
J. P. Johnson, Thilo Focken, Kuldip Khakh, Parisa Karimi Tari et autres
0 citationsbioRxiv (Cold Spring Harbor Laboratory)
CCDC 2074641: Experimental Crystal Structure Determination
Brian S. Safina, Steven J. McKerrall, Shaoyi Sun, Chien‐An Chen et autres
0 citationsThe Cambridge Structural Database
Discovery of Acyl-sulfonamide Nav1.7 Inhibitors GDC-0276 and GDC-0310
Brian S. Safina, Steven J. McKerrall, Shaoyi Sun, Chien‐An Chen et autres
43 citationsJournal of Medicinal Chemistry
Targeting of NAV1.6 and NAV1.2 to Inhibit Excitatory vs Inhibitory Neural Circuits
Samuel J. Goodchild, Mohammad‐Reza Ghovanloo, Aaron D. Williams, Noah Gregory Shuart et autres
0 citationsBiophysical Journal
CCDC 1935525: Experimental Crystal Structure Determination
Thilo Focken, Kristen Burford, Michael Grimwood, Alla Zenova et autres
0 citationsThe Cambridge Structural Database
Identification of CNS-Penetrant Aryl Sulfonamides as Isoform-Selective NaV1.6 Inhibitors with Efficacy in Mouse Models of Epilepsy
Thilo Focken, Kristen Burford, Michael Grimwood, Alla Zenova et autres
34 citationsJournal of Medicinal Chemistry
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