Panagiota Makri

Kynurenine levels are elevated in patients with heart failure with reduced ejection fraction or atrial fibrillation undergoing hemodialysis

Maria Divani, Aikaterini Katsanaki, Panagiota Makri, Christina Poulianiti et autres

Cardiovascular disease (CVD) is the leading cause of mortality in patients undergoing hemodialysis (HD). Uremic toxins may play a role in this process. One such toxin is kynurenine, a product of tryptophan metabolism that is not cleared sufficiently by HD. In the …

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Fetuin‑A and dephosphorylated uncarboxylated matrix Gla protein levels in patients with established coronary heart disease undergoing hemodialysis

Maria Divani, Aikaterini Katsanaki, Maria Tziastoudi, Panagiota Makri et autres

Fetuin-A and matrix Gla protein (MGP) protect against vascular calcification.It has been suggested that low fetuin-A levels or high levels of inactivated, dephosphorylated, uncarboxylated MGP (dp-ucMGP) may be associated with poor cardiovascular outcomes.The present study evaluated the potential of fetuin-A and dp-ucMGP …

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Inflammation and Dysregulated Bone Turnover Confound Serum ICAM-1 as a Cardiovascular Marker in Hemodialysis

Maria Divani, Aikaterini Katsanaki, Panagiota Makri, Christina Poulianiti et autres

Cardiovascular disease (CVD) remains the leading cause of mortality among hemodialysis (HD) patients, underscoring the need for reliable biomarkers for early diagnosis and management. Serum intercellular adhesion molecule-1 (ICAM-1) has been investigated for years as a potential CVD marker but has yet …

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One‑year cholecalciferol supplementation fails to improve bone mineral density or inflammation in patients with vitamin D deficiency undergoing hemodialysis

Maria Divani, Panagiota Makri, Georgios Pissas, Maria Tziastoudi et autres

Deficiency in 25‑hydroxyvitamin D [25(OH)D] is prevalent among patients undergoing hemodialysis (HD) and is associated with poorer clinical outcomes. The KDIGO guidelines advocate for 25(OH)D supplementation in these patients. In the present study, cholecalciferol was administered to patients undergoing HD exhibiting 25(OH)D …

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Late‐onset Pompe's disease in a hemodialysis patient: A first case report

Theodoros Eleftheriadis, Panagiota Makri, Paschalia Karakosta, Georgios Pissas et autres

A 37-year-old hemodialysis patient appeared with unusual somnolence during 2 successive hemodialysis sessions. Blood gas analysis revealed hypercapnic respiratory failure and spirometry restrictive lung disease. After exclusion of other causes of restrictive lung disease with chest CT-scan and cerebrum MRI, electrophysiological study …

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Increased Indoleamine 2,3-Dioxygenase in Monocytes of Patients on Hemodialysis.

Theodoros Eleftheriadis, Georgios Pissas, Georgia Antoniadi, Konstantina Tsogka et autres

Hemodialysis patients suffer from susceptibility to infections. Inflammation upregulates indoleamine 2,3-dioxygenase (IDO) in the antigen-presenting cells, which suppresses T-cell function. Plasma IDO activity or protein expression is increased in hemodialysis patients and is associated with immune disturbances. This observation, however, does not …

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Glomerular Epithelial Cells-Targeted Heme Oxygenase-1 Over Expression in the Rat: Attenuation of Proteinuria in Secondary But Not Primary Injury

Vassilios Atsaves, Panagiota Makri, Maria G. Detsika, Alexandra Tsirogianni et autres

BACKGROUND/AIMS: Induction of heme oxygenase 1 (HO-1) in glomerular epithelial cells (GEC) in response to injury is poor and this may be a disadvantage. We, therefore, explored whether HO-1 overexpression in GEC can reduce proteinuria induced by puromycin aminonucleoside (PAN) or in …

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Urate crystals induce NLRP3 inflammasome-dependent IL-1β secretion and proliferation in isolated primary human T-cells.

Theodoros Eleftheriadis, Georgios Pissas, Georgia Antoniadi, Panagiota Makri et autres

BACKGROUND: Urate through NOD-like receptor family, pyrin domain containing 3 (NLRP3) inflammasome-dependent caspase-1 activation stimulates macrophages to secrete inteleukin-1β (IL-1β). Urate also enhances adaptive immunity indirectly through its effect on antigen presenting cells. In this study, the direct effect of urate on …

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Adrenal Insufficiency As the Presenting Feature in a Patient With Lung Cancer

Georgios Zagkotsis, Pavlos Malindretos, Μαρία Μάρκου, Georgios Koutroumbas et autres

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Epidemiology and outcome research in CKD 5D

Luís Coentrão, Cassius Norris Ribeiro, Carla Santos-Araújo, Ricardo Neto et autres

Introduction and Aims: The Portuguese National Health Service funds haemodialysis (HD) and peritoneal dialysis (PD) treatments using the same bundled payment system, since 2008. However, this package does not include hospitalizations, physician/emergency room visits, access-related procedures and patient transportation. The aim of …