Sylvie Garneau‐Tsodikova

Yersinopine is a primary zinc acquisition system for Yersinia pseudotuberculosis

Mahendar Kadari, Casey Weber, Thomas E. Kehl‐Fie, Robert D. Perry et autres

ABSTRACT Y ersinia pestis is a vector-borne pathogen that evolved from the enteric pathogen Yersinia pseudotuberculosis . Despite different routes of infection, both pathogens need to overcome host-mediated zinc limitation. Y. pestis relies on the transporter ZnuABC and the metallophore yersiniabactin, but …

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Inhibition of Fosfomycin Resistance Protein FosA from Pseudomonas aeruginosa

Vanessa Wiltsie, Tatum Smith, Nishad Thamban Chandrika, Nathaniel C. Gilbert et autres

Antimicrobial resistance is an urgent issue in modern-day medicine. One way to address this problem is to repurpose and restore the function of older antibacterials through the specific targeting of antibiotic-modifying enzymes produced by bacteria. Fosfomycin is an antibiotic that is attractive …

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Crystal Structure of Trabectedin-DNA Complex

Caixia Hou, Nishad Thamban Chandrika, Markos Leggas, Sylvie Garneau‐Tsodikova et autres

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Identification of Pseudomonas aeruginosa genetic determinants that connect redox metabolism to alginate biosynthesis

Soo-Kyoung Kim, Nishad Thamban Chandrika, Ashton T. Belew, Najib M. El-Sayed et autres

ABSTRACT Pseudomonas aeruginosa is a well-known human pathogen that contributes significantly to chronic infections, particularly in cystic fibrosis (CF) patients. During this chronic infection, P. aeruginosa undergoes a phenotype change, the inactivation of mucA , which leads to the production of exopolysaccharide …

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Crystal structures and low-affinity complex formation of halogenase CtcP and FAD reductase CtcQ from the chlortetracycline biosynthetic pathway

Caixia Hou, Sylvie Garneau‐Tsodikova, Oleg V. Tsodikov

Enzymatic halogenation in natural products has been intensely investigated due to its potential utility as a tool to improve pharmacological and pharmaceutical properties of drug leads. Chlortetracycline (CTC), the first tetracycline (TC) antibiotic discovered nearly eight decades ago, contains a chlorine group. …

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Development of Zafirlukast Analogues for Improved Antithrombotic Activity Through Thiol Isomerase Inhibition

Justine A. Keovilay, Kaitlind C. Howard, Kirk A. Taylor, Sabeeya Khan et autres

BACKGROUND: Thiol isomerases play essential and nonredundant roles in platelet activation, aggregation, and thrombus formation. Thiol isomerase inhibitors have the potential to overcome the 2 major drawbacks of current antithrombotic therapies, as they target both arterial and venous thrombosis without enhancing bleeding …

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Association of COVID-19 risk factors with systemic fungal infections in hospitalized patients

Abbygail C Wilbourn, Oleg V. Tsodikov, Sylvie Garneau‐Tsodikova

Purpose: A new category of systemic co-infections that emerged with the COVID-19 pandemic is known as COVID-19-associated (CA) fungal infections, which include pulmonary aspergillosis (CAPA), candidiasis (CAC), and mucormycosis (CAM). We aimed to study the association between patient characteristics of hospitalized COVID-19 …

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Synthesis of 1,2,3-triazole containing compounds as potential antimicrobial agents

Elise L. Bezold, Robert J. Kempton, Keith D. Green, Ramey W. Hensley et autres

Invasive fungal infections are increasing worldwide due to an expanding number of immunocompromised patients as well as an increase in drug-resistant fungi. While fungal resistance has increased, this resistance has not been accompanied by the development of new antifungals. A common class …

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Zafirlukast induces DNA condensation and has bactericidal effect on replicating Mycobacterium abscessus

Sanne van der Niet, Keith D. Green, Irene M. Schimmel, Jordy de Bakker et autres

ABSTRACT Mycobacterium abscessus infections are emerging in cystic fibrosis patients, and treatment success rate in these patients is only 33% due to extreme antibiotic resistance. Thus, new treatment options are essential. An interesting target could be Lsr2, a nucleoid-associated protein involved in …

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A consensus reverse docking approach for identification of a competitive inhibitor of acetyltransferase enhanced intracellular survival protein from Mycobacterium tuberculosis

Paulo Fernando da Silva Santos-Júnior, Vitoria de Melo Batista, Igor José dos Santos Nascimento, Isabelle Cavalcante Nunes et autres

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Structural insights into the diverse prenylating capabilities of DMATS prenyltransferases

Evan T. Miller, Oleg V. Tsodikov, Sylvie Garneau‐Tsodikova

Covering: 2009 up to August 2023Prenyltransferases (PTs) are involved in the primary and the secondary metabolism of plants, bacteria, and fungi, and they are key enzymes in the biosynthesis of many clinically relevant natural products (NPs). The continued biochemical and structural characterization …

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Small molecule inhibitors of the fosfomycin resistance enzyme FosM from Mycobacterium abscessus

Skye Chiasson, Tatum Smith, Landon Bello, Nishad Thamban Chandrika et autres

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