Paolo Pagano

Evaluating accuracy and reasoning capabilities of large language models for acute ischemic stroke management

Aymen Meddeb, Navid Bakhtiari, Ida Rangus, Bastien Le Guellec et autres

BACKGROUND: Timely and accurate treatment decisions in acute ischemic stroke (AIS) are critical, particularly for intravenous thrombolysis (IVT) and mechanical thrombectomy (MT). As many patients initially present to non-specialized centers, decision-making may be delayed or inconsistent. Large language models (LLMs) have the …

de, fr, us (code pays fourni par la source)

Radiological management of reversible cerebral vasoconstriction syndrome (RCVS) in France: a national multicenter survey

Benoît Dimitrov, Thomas Samoyeau, Thibault Agripnidis, Luca Scarcia et autres

BACKGROUND AND PURPOSE: The management of reversible cerebral vasoconstriction syndrome (RCVS) lacks formal imaging guidelines, resulting in variable diagnostic and follow-up strategies. This study aimed to evaluate contemporary radiological practices for RCVS across French academic centers and to derive a pragmatic imaging …

fr (code pays fourni par la source)

Large Core Stroke Thrombectomy Is Safe and Effective Regardless of Prior Antithrombotic or Thrombolytic Treatment: A Secondary Analysis of the Randomized TENSION Trial

Eckhard Schlemm, Märit Jensen, Maximilian Schell, Jens Fiehler et autres

BACKGROUND: The relevance of prior antithrombotic and thrombolytic treatment for decision-making regarding endovascular thrombectomy (EVT) for acute ischemic stroke due to large vessel occlusion with established large infarcts is uncertain. This study investigates associations of prior antithrombotic medication and thrombolysis with the …

de, fr, no, es, at, ca, cz, dk, sk, gr (code pays fourni par la source)

Evaluating the diagnostic accuracy of vision language models for neuroradiological image interpretation

Aymen Meddeb, Ida Rangus, Paolo Pagano, Insaf Dkhil et autres

This study evaluates the diagnostic performance of commercial and open-source Vision-Language Models (VLMs) in neuroradiological image interpretation, using a dataset of 100 brain and spine cases from Radiopaedia. Five VLMs (Gemini 2.0, OpenAI o1, Llama 3.2 90b, Qwen 2.5, Grok-2-vision) were compared …

fr, de, Tunisie (code pays fourni par la source)

A282 The shallow WEB: a novel sizing strategy for saccular aneurysm embolization

Aymen Meddeb, Ilias Zekraoui, Isa Azzaki Zainal, Laurentiu Valentin Paiusan et autres

fr (code pays fourni par la source)

Thrombectomy With Low ASPECTS: The Roles of Infarct Volume and Postacute Neurological Status

Helge C. Kniep, Susanne Gellißen, Götz Thomalla, Martin Bendszus et autres

BACKGROUND: Recent randomized trials demonstrated the beneficial effect of endovascular therapy in patients with low Alberta Stroke Program Early CT Score. Despite large follow-up infarct volumes, a significantly increased rate of good functional outcomes was observed, challenging the role of infarct volume …

de, fr, no, es, at, ca, cz, dk, sk, gr (code pays fourni par la source)

Arterial Collaterals and Endovascular Treatment Effect in Acute Ischemic Stroke with Large Infarct: A Secondary Analysis of the TENSION Trial

Laurens Winkelmeier, Helge C. Kniep, Götz Thomalla, Martin Bendszus et autres

In patients with large ischemic stroke, thrombectomy within 12 hours after onset was superior to best medical treatment in reducing 90-day functional disability irrespective of the collateral status on single-phase CT angiography images.

de, fr, no, es, at, ca, cz, dk, sk, gr (code pays fourni par la source)

The impact of general anesthesia versus non–general anesthesia on thrombectomy outcomes by occlusion location: insights from the ETIS registry

Mohammad Anadani, Benjamin Gory, Jean‐Marc Olivot, Romain Bourcier et autres

OBJECTIVE: Identifying the optimal anesthetic technique for mechanical thrombectomy (MT) remains an unresolved issue. Prior research has not considered the influence of occlusion site when comparing general anesthesia (GA) with non-GA. This study evaluates the differential impacts of the anesthetic technique (GA …

fr, us, gr (code pays fourni par la source)

Endovascular thrombectomy for acute ischaemic stroke with established large infarct (TENSION): 12-month outcomes of a multicentre, open-label, randomised trial

Götz Thomalla, Jens Fiehler, Fabien Subtil, Susanne Bonekamp et autres

BACKGROUND: Long-term data showing the benefits of endovascular thrombectomy for stroke with large infarct are scarce. The TENSION trial showed the safety and efficacy of endovascular thrombectomy in patients with ischaemic stroke and large infarct at 90 days. We aimed to investigate …

de, fr, no, es, at, ca, cz, dk, sk, gr (code pays fourni par la source)

Integrating system biology and intratumor gene therapy by trans-complementing the appropriate co-stimulatory molecule as payload in oncolytic herpes virus

A Finizio, Paolo Pagano, Alessandra Napolano, Guendalina Froechlich et autres

Systems biology has been applied at the multi-scale level within the cancer field, improving cancer prevention, diagnosis and enabling precision medicine approaches. While systems biology can expand the knowledge and skills for oncological treatment, it also represents a challenging expedition due to …

it (code pays fourni par la source)

MRI vs CT for Baseline Imaging Evaluation in Acute Large Artery Ischemic Stroke

Joachim Fladt, Johannes Kaesmacher, Thomas R. Meinel, Lukas Bütikofer et autres

BACKGROUND AND OBJECTIVES: Whether MRI or CT is preferable for the evaluation of patients with suspected stroke remains a matter of debate, given that the imaging modality acquired at baseline may be a relevant determinant of workflow delays and outcomes with it, …

fr, ch (code pays fourni par la source)

Endovascular thrombectomy for acute ischaemic stroke with established large infarct: multicentre, open-label, randomised trial

Martin Bendszus, Jens Fiehler, Fabien Subtil, Susanne Bonekamp et autres

de, fr, no, es, at, ca, cz, dk, sk, gr (code pays fourni par la source)