Bixia Hong

Organoids: From Bench to Bedside Applications

Kelin Li, Rui Cao, Maochen Li, Zichao Tian et autres

Organoids are three-dimensiona(3D) models derived from stem cells that closely replicate the structure and cellular complexity of human tissues, providing physiologically relevant platforms for biomedical research. This technology addresses the limitations of two-dimensional (2D) cultures, reduces species-specific discrepancies, and is particularly valuable …

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Lactoferrin blocks orthopoxvirus entry via heparan sulphate and regulates host antiviral pathways

Lili Tian, Hongbo Qin, Sha Li, Mengjie Zhang et autres

Current antiviral therapies for orthopoxviruses face critical challenges, including limited efficacy and significant toxicity, which impede outbreak containment and clinical management. Here, we identify lactoferrin as a potent antiviral agent against multiple orthopoxvirus strains. Combination administration of lactoferrin with brincidofovir or tecovirimat …

Lactoferrin blocks orthopoxvirus entry via heparan sulphate and regulates host antiviral pathways

Lili Tian, Hongbo Qin, Sha Li, Mengjie Zhang et autres

Current antiviral therapies for orthopoxviruses face critical challenges, including limited efficacy and significant toxicity, which impede outbreak containment and clinical management. Here, we identify lactoferrin as a potent antiviral agent against multiple orthopoxvirus strains. Combination administration of lactoferrin with brincidofovir or tecovirimat …

Lactoferrin blocks orthopoxvirus entry via heparan sulphate and regulates host antiviral pathways

Lili Tian, Hongbo Qin, Sha Li, Mengjie Zhang et autres

Current antiviral therapies for orthopoxviruses face critical challenges, including limited efficacy and significant toxicity, which impede outbreak containment and clinical management. Here, we identify lactoferrin as a potent antiviral agent against multiple orthopoxvirus strains. Combination administration of lactoferrin with brincidofovir or tecovirimat …

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Evolution of H5N1 Cross‐Species Transmission: Adaptive Mutations Driving Avian‐to‐Human Infection

Wenxin Man, Lin Du, Ying Liu, Zehan Pang et autres

First detected in poultry in China in 1996, the H5N1 avian influenza virus has evolved into a significant global public health hazard, primarily owing to its high pathogenicity and potential for interspecies transmission. While primarily affecting avian species, H5N1 has repeatedly breached …

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Optogenetic Regulation of Integrated Stress Responses: Developing Novel Broad‐Spectrum Antiviral Strategies

Zehan Pang, Bixia Hong

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[Development and antiviral activity of cepharanthine nanomicelles].

Ke Liu, Yuan Rao, Bixia Hong, Shengdong Luo et autres

reaching 0.016 8 μmol/L. The animal experiment results revealed that CEP nanomicelles significantly reduced viral RNA levels in the lung tissue and achieved more stable plasma drug concentrations. Overall, CEP nanomicelles substantially improved the solubility and antiviral performance of CEP, exhibiting broad-spectrum …

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HSBDF-Derived Bioactive Components Broadly Inhibit Enteroviruses by Targeting 3C Protease and Attenuating Inflammatory Responses

Ruolan Hu, Lin Guan, Siyue Li, Chunlin Liu et autres

Human enteroviruses are important pathogens of hand-foot-and-mouth disease, poliomyelitis, and encephalitis, etc., posing substantial global health burdens with no specific approved therapeutics. While traditional Chinese medicine (TCM) has demonstrated antiviral potential during the COVID-19 pandemic, its efficacy and pharmacodynamic material basis against …

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[Optimization of cepharanthine solubility and evaluation of its inhibitory activity against coronaviruses].

Yihan Zhang, Ke Liu, Hongbo Qin, Bixia Hong et autres

=1.05 μmol/L, SI>47). In conclusion, both the vitamin C-based formulation and CEP hydrochloride significantly improved the solubility and antiviral activity of CEP, highlighting its potential for further pharmaceutical development and clinical application.

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The potential mechanisms and material basis of Fuzheng Jiedu decoction broad-spectrum inhibiting coronaviruses

Ke Liu, Bixia Hong, Shiting He, Shu‐Shan Du et autres

Traditional Chinese medicine has unique advantages in preventing and treating COVID-19, and Fuzheng Jiedu decoction (FZJDD) was reported to be effective against COVID-19 in clinical trials. To investigate the potential mechanisms and material basis of FZJDD against SARS-CoV-2, we performed SARS-CoV-2 target …

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SARS‐CoV‐2 Omicron subvariants from BA.2 to BA.2.86 and JN.1: strong lung infection ability and evolving immune escape capacity

Bixia Hong, Maochen Li, Huahao Fan

in Nature 3 and The Lancet Infectious Disease 4 revealed that the SARS-CoV-2 Omicron BA.2 subvariant BA.2.86 exhibited high lung cell tropism and distinct antigenic epitopes, and its sublineage JN.1 even outperformed BA.2.86 in immune escape ability.These findings indicate that the BA.2.86 …

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Rapid and highly sensitive colorimetric LAMP assay and integrated device for visual detection of monkeypox virus

Yadan Peng, Ruolan Hu, Shuang Xue, Yugan He et autres

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