Sebastian Wieland

Neural, psychological, and daily life evidence for a transdiagnostic process of affective dysregulation in depression and chronic widespread pain

Malika Renz, Hannah Schmidt, Armin Drusko, Oksana Berhe et autres

ABSTRACT: Chronic pain and depression are leading causes of disability, frequently co-occurring and exacerbating each other. This cross-sectional study investigated putative transdiagnostic processes of affective dysregulation in fibromyalgia (FMS) and major depressive disorder (MDD) using psychometric questionnaires (Beck Depression Inventory-II, Hospital Anxiety …

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Die Bidirektionale Beziehung zwischen chronischem Schmerz und traumatischen Lebensereignissen

Michelle Hermes, Sebastian Wieland, Jonas Tesarz

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2MDR, a Microcomputer-Controlled Visual Stimulation Device for Psychotherapy-Like Treatments of Mice

Isa Jauch, Jan Kamm, Luca Benn, Lukas Rettig et autres

Post-traumatic stress disorder and other mental disorders can be treated by an established psychotherapy called Eye Movement Desensitization and Reprocessing (EMDR). In EMDR, patients are confronted with traumatic memories while they are stimulated with alternating bilateral stimuli (ABS). How ABS affects the …

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Layer-specific pain relief pathways originating from primary motor cortex

Zheng Gan, Vijayan Gangadharan, Sheng Liu, Christoph Körber et autres

The primary motor cortex (M1) is involved in the control of voluntary movements and is extensively mapped in this capacity. Although the M1 is implicated in modulation of pain, the underlying circuitry and causal underpinnings remain elusive. We unexpectedly unraveled a connection …

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Study of Z boson plus jets events using variables sensitive to double-parton scattering in pp collisions at 13 TeV

CMS Collaboration, Armen Tumasyan, Natascha Krammer, Alves GA et autres

Phasic dopamine reinforces distinct striatal stimulus encoding in the olfactory tubercle driving dopaminergic reward prediction

Lars‐Lennart Oettl, Max Scheller, Carla Filosa, Sebastian Wieland et autres

The learning of stimulus-outcome associations allows for predictions about the environment. Ventral striatum and dopaminergic midbrain neurons form a larger network for generating reward prediction signals from sensory cues. Yet, the network plasticity mechanisms to generate predictive signals in these distributed circuits …

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Phasic dopamine enhances the distinct decoding and perceived salience of stimuli

Lars‐Lennart Oettl, Max Scheller, Sebastian Wieland, Franziska Haag et autres

Abstract Subjects learn to assign value to stimuli that predict outcomes. Novelty, rewards or punishment evoke reinforcing phasic dopamine release from midbrain neurons to ventral striatum that mediates expected value and salience of stimuli in humans and animals. It is however not …

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GluN2B-Containing NMDA Receptors Promote Glutamate Synapse Development in Hippocampal Interneurons

Wolfgang Kelsch, Zhijun Li, Sebastian Wieland, Oleg Senkov et autres

In postnatal development, GluN2B-containing NMDARs are critical for the functional maturation of glutamatergic synapses. GluN2B-containing NMDARs prevail until the second postnatal week when GluN2A subunits are progressively added, conferring mature properties to NMDARs. In cortical principal neurons, deletion of GluN2B results in …

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Phasic Dopaminergic Activity Exerts Fast Control of Cholinergic Interneuron Firing via Sequential NMDA, D2, and D1 Receptor Activation

Sebastian Wieland, Dan Du, M.J. Oswald, Rosanna Parlato et autres

Phasic increases in dopamine (DA) are involved in the detection and selection of relevant sensory stimuli. The DAergic and cholinergic system dynamically interact to gate and potentiate sensory inputs to striatum. Striatal cholinergic interneurons (CINs) respond to relevant sensory stimuli with an …

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