Yan‐Jye Shyong

Antigen-Loaded and Calcium-Incorporated Chitosan Oligosaccharide Nanoparticles for Dendritic Cell Cross-Presentation and Immunotherapy

Cheng‐Ping Yu, Jui‐Chen Tsai, Yan‐Jye Shyong

Background: Cancer vaccines, a type of immunotherapy for cancer treatment, have been extensively studied over the years. Antigen-presenting cells (APCs) such as dendritic cells (DCs) and macrophages play a crucial role in vaccine therapies by presenting specific antigens to helper or cytotoxic …

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Antigen-Loaded and Calcium-Incorporated Chitosan Oligosaccharide Nanoparticles for Dendritic Cell Cross-Presentation and Immunotherapy

Yu CP, Tsai JC, Yan‐Jye Shyong

Cheng-Ping Yu, Jui-Chen Tsai, Yan-Jye ShyongSchool of Pharmacy, College of Medicine, National Cheng Kung University, Tainan, TaiwanCorrespondence: Yan-Jye Shyong, Email bear901704@gs.ncku.edu.twBackground: Cancer vaccines, a type of immunotherapy for cancer treatment, have been extensively studied over the years. Antigen-presenting cells (APCs) such as …

Comparative Study of Acrylic and Acetic Acid Precursors on Plasma-Induced Carboxylation for Antibiotic-Antimycotic Coatings

Anindita Bhar, Asnake Ketema, S. Aliasghari, Allan Matthews et autres

A diverse range of monomers is commonly used in processes involving the deposition of carboxylic acid functional groups onto surfaces. These processes support various applications for polymeric materials, including the development of antibacterial coatings, improved biocompatibility, controlled surface wettability, use in environmental …

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Variations in ECM Topography, Fiber Alignment, Mechanical Stiffness, and Cellular Composition Between Ventral and Dorsal Ligamentum Flavum Layers: Insights Into Hypertrophy Pathogenesis

Ting‐Yuan Tu, Yu‐Chia Hsu, Yan‐Jye Shyong, Cheng‐Hsiang Kuo et autres

Background: Previous studies have suggested that changes in the composition of the extracellular matrix (ECM) play a significant role in the development of ligamentum flavum hypertrophy (LFH) and the histological differences between the ventral and dorsal layers of the hypertrophied ligamentum flavum. …

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Calcium phosphate complex of recombinant human thrombomodulin promote bone formation in interbody fusion

Cheng‐Li Lin, Yu-Wei Chen, Cheng‐Hsiang Kuo, Ting‐Yuan Tu et autres

Abstract Interbody fusion is an orthopedic surgical procedure to connect two adjacent vertebrae in patients suffering from spinal disc disease. The combination of synthetic bone grafts with protein-based drugs is an intriguing approach to stimulate interbody bone growth, specifically in patients exhibiting …

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Delivery of extracellular vesicles loaded with immune checkpoint inhibitors for immunotherapeutic management of glioma

Shang-Wen Lin, Cheng‐Ping Yu, Jui‐Chen Tsai, Yan‐Jye Shyong

, as correlated with the conditioning method. ICI/EVs were successfully prepared with high loading efficiency using the sonication method. The EVs can be distributed throughout the entire brain upon intranasal administration and facilitate ICIs distribution into glioma lesion. Combinatory treatment with ICI/EVs …

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BMSC loaded photo-crosslinked hyaluronic acid/collagen hydrogel incorporating FG4592 for enhanced cell proliferation and nucleus pulposus differentiation

Cheng‐Li Lin, Yu‐Wen Su, Yu-Wei Chen, Cheng‐Hsiang Kuo et autres

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Amphiphilic NLC-Gel formulation loaded with Sebacoyl dinalbuphine ester and Nalbuphine for localized postoperative pain management

Cheng‐Li Lin, Yi-Lian Li, Yu-Wei Chen, Cheng‐Hsiang Kuo et autres

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Long acting tariquidar loaded stearic acid-modified hydroxyapatite enhances brain penetration and antitumor effect of temozolomide

Cheng‐Ping Yu, Shang-Wen Lin, Jui‐Chen Tsai, Yan‐Jye Shyong

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Evaluation of calcium phosphate-zoledronic acid microparticles as a localized delivery system on bone defect: An in vivo study

Kuo‐Yuan Huang, Yu-Wei Chen, Tzu-Yu Liang, M. W. Lai et autres

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Pulmonary delivery of remdesivir and dexamethasone encapsulated nanostructured lipid carriers for enhanced inflammatory suppression in lung

Chian‐Wei Chen, Chun‐Ping Chang, Yi-Shuan Wen, Cheng‐Hsiang Kuo et autres

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Porous hydroxyapatite carrier enables localized and sustained delivery of honokiol for glioma treatment

Feng‐Huei Lin, Yu‐Chen Hsu, Kuo-Chi Chang, Yan‐Jye Shyong

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