Haoyu Zheng

Bioactive Polythioctic Acid-Engineered Ropivacaine Alleviates Bone Cancer Pain Through Prolonged Analgesia and Multi-functional Neuroprotection

Ziping Wu, Yucen Zhang, Yan Guo, Yueying Wang et autres

Bone cancer pain (BCP), driven by tumor-induced bone destruction and central sensitization, represents a major clinical challenge. Although ropivacaine (Rop) is a cornerstone for BCP management, it fails to provide prolonged analgesia and neuroprotective benefits. Through RNA transcriptomics and phenotypic analysis in …

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BOBM: an adaptive deep learning framework for extended-window sepsis prediction with cross-institutional generalizability

Wanxuan Li, Kai Xiao, Boyuan Gu, Haoyu Zheng et autres

Introduction: Sepsis, a life-threatening and costly condition, necessitates early detection for effective management. However, diagnostic and therapeutic delays are common. Furthermore, sepsis complexity and dynamics challenge existing early warning systems, impeding timely intervention. Methods: In this study, we introduce the Bayes-Optimized Boosting-Mamba …

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Osteoimmunology uncovered: How macrophages and biomaterials revolutionize bone healing

Yu Wang, Bingnan Wang, Dongsong Liu, Liqing Xu et autres

With an increasingly aging society, bone defects and fractures have become significant threats to human health and quality of life. Currently, in situ bone repair represents a burgeoning niche within the realm of regenerative materials, achieving notable advancements in bone restoration. Numerous …

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MOCapsNet: Multiomics Data Integration for Cancer Subtype Analysis Based on Dynamic Self-Attention Learning and Capsule Networks

Yuanyuan Zhang, Haoyu Zheng, Xiaokun Meng, Qihao Wang et autres

Background and Objective: With the rapid development of the accumulation of large-scale multiomics data sets, integrating various omics data to provide a thorough study from multiple perspectives can significantly provide stronger support for precise treatment of diseases. However, due to the complexity …

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RCAN-DDI: Relation-aware cross adversarial network for drug-drug interaction prediction

Yuanyuan Zhang, Xiaoyu Xu, Bao-Ming Feng, Haoyu Zheng et autres

Drug-drug interaction (DDI) refers to the interaction between two or more drugs in the body, altering their efficacy or pharmacokinetics. Fully considering and accurately predicting DDI has become an indispensable part of ensuring safe medication for patients. In recent years, many deep …

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3D-printed zinc oxide nanoparticles modified barium titanate/hydroxyapatite ultrasound-responsive piezoelectric ceramic composite scaffold for treating infected bone defects

Kai Chen, Fang Wang, Xiu-Mei Sun, Wenwei Ge et autres

Clinically, infectious bone defects represent a significant threat, leading to osteonecrosis, severely compromising patient prognosis, and prolonging hospital stays. Thus, there is an urgent need to develop a bone graft substitute that combines broad-spectrum antibacterial efficacy and bone-inductive properties, providing an effective …

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Preparation of Budesonide-Loaded Liposomal Nanoparticles for Pulmonary Delivery and Their Therapeutic Effect in OVA-Induced Asthma in Mice

Xu Zuo, Yinuo Gu, Xiaoping Guo, Wenxue Zheng et autres

Purpose: Inhaled corticosteroids, including budesonide (BUD), are widely employed for the treatment of asthma. However, the frequent use of corticosteroids is associated with numerous adverse effects and poses challenges to ongoing drug therapy and patient adherence. Budesonide liposomal nanoparticles (BUD-LNPs) were developed …

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3d-Printed Zinc Oxide Nanoparticles Modified Barium Titanate/Hydroxyapatite Ultrasound-Responsive Piezoelectric Ceramic Composite Scaffold: A Novel Approach for Accelerating Bone Regeneration in Infected Rat Skull Defects

Kai Chen, Fang Wang, Xiu-Mei Sun, Wenwei Ge et autres

Ensemble Network for Alzheimer’s Disease Diagnosis

Liang Chen, Yande Wang, Haoyu Zheng, Dong Liang et autres

Alzheimer’s disease (AD) is a common progressive neurodegenerative disorder characterized by a gradual decline in patients’ behavior, memory, and cognition. However, due to the complexity and low quality of medical images, a single neural network may not fully leverage the relevant features …

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Efferocytosis and Respiratory Disease

Wenxue Zheng, Zhengjie Zhou, Xiaoping Guo, Xu Zuo et autres

Cells are the smallest units that make up living organisms, which constantly undergo the processes of proliferation, differentiation, senescence and death. Dead cells need to be removed in time to maintain the homeostasis of the organism and keep it healthy. This process …

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PLGA-Based Micro/Nanoparticles: An Overview of Their Applications in Respiratory Diseases

Xiaoping Guo, Xu Zuo, Zhengjie Zhou, Yinuo Gu et autres

Respiratory diseases, such as asthma and chronic obstructive pulmonary disease (COPD), are critical areas of medical research, as millions of people are affected worldwide. In fact, more than 9 million deaths worldwide were associated with respiratory diseases in 2016, equivalent to 15% …

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Recent Advances in Nanomaterials for Asthma Treatment

Xu Zuo, Xiaoping Guo, Yinuo Gu, Haoyu Zheng et autres

Asthma is a chronic airway inflammatory disease with complex mechanisms, and these patients often encounter difficulties in their treatment course due to the heterogeneity of the disease. Currently, clinical treatments for asthma are mainly based on glucocorticoid-based combination drug therapy; however, glucocorticoid …

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