Melissa Cortez

Hyperadrenergic and neuropathic features based on clinical autonomic testing in individuals with POTS: an observational cross-sectional study

Jonathan Trout, Guillaume Lamotte, Jordan Langford, Luke Heyliger et autres

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Postural Orthostatic Tachycardia Syndrome (POTS) and Dysautonomia: International Multidisciplinary Expert Consensus

Kirti Sivakoti, Melissa Cortez, Artur Fedorowski, Marat Fudim et autres

BACKGROUND: Current diagnostic criteria for postural orthostatic tachycardia syndrome (POTS) require history of orthostatic intolerance and heart rate elevation of ≥30 bpm in adults or ≥40 bpm in adolescents during a 10-minute standing or a tilt table test. Many patients with orthostatic …

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Dysregulated Cardiovascular Autonomic Responses to Orthostatic Challenge in Mild Traumatic Brain Injury

Ryan Pelo, Geoffrey Laforge, Cecilia Martindale, Peter C. Fino et autres

Mild traumatic brain injury (mTBI) often presents with symptoms of dizziness, headache, and brain fog. Prior work has linked these symptoms to impaired autonomic nervous system function and associated changes in cerebral blood flow after mTBI. Arterial baroreflex function is central to …

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Sensory Discomfort Across the Migraine Cycle

Sarah M. Haigh, Melissa Cortez, Rory Thompson, Anastasia Chevychalova et autres

Sensory discomfort is a core complaint in migraine, particularly during the migraine headache, and fluctuates over the migraine cycle. Here, we examine the potential for monitoring sensory discomfort as a predictive symptom of approaching migraine pain. Two studies were conducted. For Study …

Perspective of Patients with Dysautonomia on Home-Based Telerehabilitation

Aileen Gabriel, Aref Smiley, Patricia Rocco, Katie Johnson et autres

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Efficacy and outcomes of pharmacological treatments for headaches after traumatic brain injury: A systematic review

Shirin Saleh, Emma Sanford, Donald D. McGeary, Melissa Cortez et autres

Background Headache following traumatic brain injury (TBI) is a common, yet disabling, disorder with diverse mechanisms and treatment needs that remain poorly defined. Pharmacological regimens are the primary source of remedies for individuals with post-traumatic headaches (PTH). The main objective of this …

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Impact of Excessive Postural Tachycardia on Disability in Youth with Orthostatic Intolerance

Kirti Sivakoti, Olivia Parnell, Corinne Espinoza, Casey Tak et autres

OBJECTIVE: To compare Functional Disability Inventory (FDI) between adolescents with chronic orthostatic intolerance (COI) and postural orthostatic tachycardia syndrome (POTS). STUDY DESIGN: This cross-sectional study included adolescents ≤19 years with orthostatic symptoms >3 months referred to a tertiary pediatric autonomic clinic (August …

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Long COVID trajectories in the prospectively followed RECOVER-Adult US cohort

Tanayott Thaweethai, Sarah E. Donohue, Jeffrey N. Martin, Mady Hornig et autres

Longitudinal trajectories of Long COVID remain ill-defined, yet are critically needed to advance clinical trials, patient care, and public health initiatives for millions of individuals with this condition. Long COVID trajectories were determined prospectively among 3,659 participants (69% female; 99.6% Omicron era) …

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Olfactory Dysfunction After SARS-CoV-2 Infection in the RECOVER Adult Cohort

Leora I. Horwitz, Jacqueline Becker, Weixing Huang, Teresa Akintonwa et autres

Importance: Olfactory dysfunction is common after SARS-CoV-2 infection and has been associated with cognitive loss in other conditions. Formal testing is needed to characterize the presence, severity, and patterns of olfactory dysfunction. Objective: To characterize long-term olfactory dysfunction after SARS-CoV-2 infection. Design, …

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Increased occurrence of migraine aura and susceptibility to spreading depolarizations at altitude

Katelyn M. Reinhart, Melissa Cortez, Cecilia Martindale, Leon S. Moskatel et autres

Headache is a common consequence of ascent to high altitudes, and acute mountain sickness shares many features with migraine. Evidence also suggests that the prevalence of migraine is increased in people living at both high and moderate elevations. Here we identify an …

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Impact of Excessive Postural Tachycardia on Disability in Youth with Orthostatic Intolerance

Kirti Sivakoti, Olivia Parnell, Corinne Espinoza, Casey Tak et autres

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Characterizing Long COVID Symptoms During Early Childhood

Rachel S. Gross, Tanayott Thaweethai, Amy L. Salisbury, Lawrence C. Kleinman et autres

Importance: Recent studies have identified characteristic symptom patterns of long COVID (LC) in adults and children older than 5 years. However, LC remains poorly characterized in early childhood. This knowledge gap limits efforts to identify, care for, and prevent LC in this …

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