Silvia Monticelli

FCRL3 is an immunoregulatory receptor that restrains the activation of human memory T lymphocytes

Niccolò Bianchi, Elena Foli, Mehrpouya Mostanfar, Roberta Marzi et autres

Genetic variants in the FCRL3 gene are linked to autoimmune disorders. However, the functional properties of FCRL3-expressing T lymphocytes, and the regulation and functional impact of FCRL3 expression remain understudied. Here, we performed a multiomic and functional analysis of human T lymphocytes …

Brain infiltrating T cells mediate microglial dysregulation and neuronal loss following SAH

Federico Moro, Edoardo Mazzone, Rosaria Pascente, Marian Bataclan et autres

Abstract The contribution of T cells to neuroinflammation after aneurysmal subarachnoid hemorrhage (SAH) remains poorly understood. Using a murine pre-chiasmatic injection model of SAH we demonstrate that T cell infiltration into the brain modulates microglial activation and promotes neuronal death. Targeted transcriptomic …

it, ch (code pays fourni par la source)

FCRL3 is an immunoregulatory receptor that restrains the activation of human memory T lymphocytes

Nicoletta Bianchi, Elena Foli, Mehrpouya Mostanfar, Roberta Marzi et autres

FCRL3 is an immunoregulatory receptor that restrains the activation of human memory T lymphocytes

Niccolò Bianchi, Elena Foli, Mehrpouya Mostanfar, Roberta Marzi et autres

Genetic variants in the FCRL3 gene are linked to autoimmune disorders. However, the functional properties of FCRL3-expressing T lymphocytes, and the regulation and functional impact of FCRL3 expression remain understudied. Here, we performed a multiomic and functional analysis of human T lymphocytes …

ch, it (code pays fourni par la source)

ROQUIN-1 binding to the transcriptome of T cells reveals conserved targets in the control of lymphopoiesis

Vigo Heissmeyer, Elaine Y.M. Wong, Giulia Cantini, Gesine Behrens et autres

de, jp, cn (code pays fourni par la source)

Crosstalk between Regnase-1 and -3 shapes mast cell survival and cytokine expression

Marian Bataclan, Cristina Leoni, Simone G. Moro, Matteo Pecoraro et autres

Post-transcriptional regulation of immune-related transcripts by RNA-binding proteins (RBPs) impacts immune cell responses, including mast cell functionality. Despite their importance in immune regulation, the functional role of most RBPs remains to be understood. By manipulating the expression of specific RBPs in murine …

de (code pays fourni par la source)

Author Reply to Peer Reviews of Crosstalk between the RNA-binding proteins Regnase-1 and -3 shapes mast cell survival and cytokine expression

Marian Bataclan, Cristina Leoni, Simone G. Moro, Matteo Pecoraro et autres

us, de (code pays fourni par la source)

Activation of endogenous retroviruses and induction of viral mimicry by MEK1/2 inhibition in pancreatic cancer

Alice Cortesi, Francesco Gandolfi, Fabiana Arco, Pierluigi Di Chiaro et autres

While pancreatic ductal adenocarcinomas (PDACs) are addicted to KRAS-activating mutations, inhibitors of downstream KRAS effectors, such as the MEK1/2 kinase inhibitor trametinib, are devoid of therapeutic effects. However, the extensive rewiring of regulatory circuits driven by the attenuation of the KRAS pathway …

it, us, ch (code pays fourni par la source)

Editorial: T cell specificity and cross-reactivity – implications in physiology and pathology

Daniela Latorre, Silvia Monticelli, Tomasz P. Wypych, Dominik Aschenbrenner et autres

ISSN:1664-3224

ch, pl, it (code pays fourni par la source)

Crosstalk between the RNA-binding proteins Regnase-1 and -3 shapes mast cell survival and cytokine expression

Marian Bataclan, Cristina Leoni, Simone G. Moro, Matteo Pecoraro et autres

Abstract Post-transcriptional regulation of immune-related transcripts by RNA-binding proteins (RBPs) impacts immune cell responses, including mast cell functionality. Despite their importance in immune regulation, the functional role of most RBPs remains to be understood. By manipulating the expression of specific RBPs in …

ch, hr, de, gb (code pays fourni par la source)

DNA sensing and repair systems unexpectedly team up against cancer

Silvia Monticelli, Petr Ćejka

ch (code pays fourni par la source)

The mRNA methyltransferase Mettl3 modulates cytokine mRNA stability and limits functional responses in mast cells

Cristina Leoni, Marian Bataclan, Taku Ito-Kureha, Vigo Heissmeyer et autres

Abstract Mast cells are central players in allergy and asthma, and their dysregulated responses lead to reduced quality of life and life-threatening conditions such as anaphylaxis. The RNA modification N6-methyladenosine (m6A) has a prominent impact on immune cell functions, but its role …

ch, de (code pays fourni par la source)