Lynn Wang

Abstract A011: OSTM1 restrains B-cell lymphomagenesis by promoting PDE3B degradation and activating cAMP-PKA-CREB signaling

Muhammad Usama. Tariq, Namratha Sheshadri, Jianliang Shen, Jaeyong Jung et autres

Abstract Through a genome-wide forward CRISPR/Cas9 screen in interleukin-3 (IL3)-dependent Ba/F3 cells, we identified osteoclastogenesis-associated transmembrane protein 1 (OSTM1) as a previously unrecognized tumor suppressor. Analysis of patient datasets revealed that OSTM1 is frequently deleted or downregulated in human B-cell lymphomas (BCL). …

us, ch, ca (code pays fourni par la source)

Abstract 617: OSTM1 is a ubiquitin E3 ligase that suppresses B-cell malignancy by activating the cAMP/PKA pathway.

Muhammad Usama Tariq, Namratha Sheshadri, Julia Shen, Jaeyong Jung et autres

Abstract Osteoclastogenesis-associated transmembrane protein 1 (OSTM1) is a membrane-integral glycosylated protein that regulates lysosomal homeostasis and osteoclast maturation. Its loss-of-function mutations cause autosomal recessive osteopetrosis (ARO). In addition, OSTM1 was described as a putative ubiquitin E3 ligase yet with ill-defined substrates and …

us, ca (code pays fourni par la source)

HIRA-mediated H3.3 deposition preserves hepatocyte cell identity during liver aging

Rouven Arnold, Marcos G. Teneche, Xue Lei, Armin Gandhi et autres

Abstract Age-associated functional decline is partly driven by progressive chromatin degeneration. Maintenance of chromatin integrity preserves cell identity and promotes healthy aging, but through different mechanisms in proliferating and non-proliferating cells. However, specific mechanisms of chromatin maintenance and their compensatory capacity in …

us, de, hu, pk, Cameroun (code pays fourni par la source)

Remyelination and its association with increased oxygen extraction fraction in acute multiple sclerosis lesions

Praveena Elanghovan, Liukailai Ding, T. Nguyen, Shun Zhang et autres

The study investigates the relationship between longitudinal changes in oxygen extraction fraction (OEF) and remyelination in acute multiple sclerosis (MS) lesions. Twenty-two MS patients with 68 new gadolinium-enhancing lesions underwent MRI scans at baseline, 3 months, and 12 months. OEF was quantified …

us (code pays fourni par la source)

OSTM1 is a ubiquitin E3 ligase that suppresses B-cell malignancy by activating the cAMP/PKA/CREB pathway

Muhammad Usama Tariq, Namratha Sheshadri, Jianliang Shen, Jaeyong Jung et autres

Abstract Osteoclastogenesis-associated transmembrane protein 1 (OSTM1) is a membrane-integral glycosylated protein known for regulating lysosomal homeostasis, with loss-of-function mutations causing autosomal recessive osteopetrosis. Through a whole-genome CRISPR/Cas9 screen, we identified OSTM1 as a critical tumor suppressor in B-cell malignancies. In humans, OSTM1 …

us, ch, ca (code pays fourni par la source)

Isatuximab in combination with chemotherapy for pediatric patients with relapsed/refractory acute lymphoblastic leukemia or acute myeloid leukemia: The ISAKIDS study

André Baruchel, Karsten Nysom, Hyoung Jin Kang, Marı́a Sara Felice et autres

Abstract Children with relapsed acute leukemia have a poor prognosis; current relapse treatments are toxic, and novel treatments are needed. The anti‐CD38 antibody isatuximab is approved for relapsed‐refractory multiple myeloma in adults. We present results of the ISAKIDS study (NCT03860844) investigating isatuximab …

fr, dk, kr, ar, br, gr, it, mx, no, pe, pt, se, us, nl (code pays fourni par la source)

In vitro neurotoxicity comparison: Colistimethate induces higher toxicity than colistin via formaldehyde accumulation

Jing Lü, Yan Zhu, Mengyao Li, Yimin Wu et autres

us, cn, au (code pays fourni par la source)

Ceftolozane/tazobactam disrupts Pseudomonas aeruginosa biofilms under static and dynamic conditions

Xenia Kostoulias, Ying Fu, Faye C. Morris, Crystal Yu et autres

BACKGROUND: Pseudomonas aeruginosa biofilms limit the efficacy of currently available antibacterial therapies and pose significant clinical challenges. Pseudomonal biofilms are complicated further when other markers of persistence such as mucoid and hypermutable phenotypes are present. There is currently a paucity of data …

us, au, ca, cn (code pays fourni par la source)

Evaluating ambroxol as an agent to boost lysosomal function and reduce beta amyloid in 3xTg mice

Adrianna R Tsang, Lynn Wang, Stephen Pasternak

BACKGROUND: Ambroxol is an expectorant under study as a treatment for synucleinopathies, such as Parkinson's disease. It is a pharmacological chaperone of the lysosomal enzyme β-glucocerebrosidase (GCase), increasing this enzyme and subsequently reducing accumulation of alpha-synuclein. Although the mechanism of enhanced clearance …

ca (code pays fourni par la source)

Efficacy of meropenem extended infusion vs intermittent bolus monotherapy and in combination with colistin against Pseudomonas aeruginosa biofilm

Eva Benavent, Marta Ulldemolins, Cristina El Haj, Raül Rigo‐Bonnin et autres

es, au (code pays fourni par la source)

A Transmitter Equalizer scheme with FFE and internal boost scheme for achieving over 6Gbps in DDR interface

Elaine Tang, Chris Soo-Hyun Eom, Lynn Wang, Zhiqiang Zhang et autres

A transmitter equalizer scheme with FFE and internal boost scheme is presented. For achieving over 6Gbps speed, 4:1 MUX structure is proposed, as well as Quadrate Error Correction (QEC) and internal boost is implemented for reducing jitter. As a result, signal eye …

cn (code pays fourni par la source)

Transcriptomics of angiotensin II-induced long noncoding and coding RNAs in endothelial cells

Shuhan Bu, Hien C. Nguyen, David Michels, Berk Rasheed et autres

OBJECTIVE: Angiotensin II (Ang II)-induced endothelial dysfunction plays an important role in the pathogenesis of cardiovascular diseases such as systemic hypertension, cardiac hypertrophy and atherosclerosis. Recently, long noncoding RNAs (lncRNAs) have been shown to play an essential role in the pathobiology of …

ca (code pays fourni par la source)