Dun Xiong

Neoadjuvant Anbenitamab and HB1801 in ERBB2 -Positive Breast Cancer

Junjie Li, Tong Liu, Ke-Da Yu, Huawei Yang et autres

IMPORTANCE: The combination of neoadjuvant taxanes with trastuzumab and pertuzumab remains the cornerstone treatment strategy in ERBB2-positive breast cancer. Anbenitamab (a ERBB2-biparatopic antibody that induces profound receptor clustering) and HB1801 (a solvent-free albumin-bound docetaxel), have shown promising antitumor activity and an acceptable …

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Association Between Dietary Anthocyanidin Intake and Thyroid Autoimmunity: A Cross‐Sectional Study From NHANES (2007–2010)

Mingkuan Chen, Yirong Yuan, Yuan Zhao, Siyu Wu et autres

ABSTRACT Background Despite extensive documentation of the immunomodulatory effects of anthocyanidins, population‐based epidemiological studies have yet to elucidate their association with thyroid autoimmunity (TAI). Methods Using flavonoid intake data from the Flavonoid and Anthocyanidin Database (FNDDS) and 2007–2010 National Health and Nutrition …

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WITHDRAWN: 2772P Impact of radiation dose to immune cells on survival in patients with extensive-stage small cell lung cancer receiving consolidative thoracic radiotherapy after chemoimmunotherapy

Chunhong Feng, Kai You Wang, Feng Xu, Li Li et autres

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Prognostic Biomarkers and Virtual Drug Targets for Endometrial Cancer: A Comprehensive Analysis of TCGA Database and Molecular Docking

Zhengyong Luo, Qili Wu, Dun Xiong

Endometrial cancer is a prevalent malignancy of the female reproductive system. In recent years, with the changes in the pace of life, Endometrial cancer incidence and death have gradually risen. It is difficult to detect in the early stage and the mortality …

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Pyrotinib and trastuzumab plus palbociclib and fulvestrant in HR+/HER2+ breast cancer patients with brain metastasis

Dongshao Chen, Fei Xu, Yongkui Lu, Wen Xia et autres

Human epidermal growth factor receptor 2-positive (HER2+) breast cancer (BC) patients are at a high risk of developing metastases in the brain. However, research focusing on treatment strategies for hormonal receptor positive (HR+), HER2+ BC patients with brain metastases (BM) remains limited. …

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Cervical cancer subtype identification and model building based on lipid metabolism and post-infection microenvironment immune landscape

Yongzhi Chen, Rongjie Cui, Dun Xiong, Yuan Zhao et autres

Background: As the second most common gynecological cancer, cervical cancer (CC) seriously threatens women's health. The poor prognosis of CC is closely related to the post-infection microenvironment (PIM). This study investigated how lipid metabolism-related genes (LMRGs) affect CC PIM and their role …

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Application of multigene panel detection in breast cancer

Yuan Zhao, Dun Xiong, Bo Yang, Shaocai Xia et autres

Precision medicine will be the direction of future medical development, especially in cancer diagnosis and treatment. With the deepening of breast cancer-related research, new factors related to diagnosis, treatment and prognosis are constantly being discovered. Researchers combine different factorsto form a multigene …

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Abstract 2184: Gene characteristics of Chinese patients with small bowel cancer

Quan Zhao, Hushan Zhang, Zhuyun Lei, Jianing Sheng et autres

Abstract Background: Small bowel cancer is a rare malignancy which account for only 1-3% of all malignant gastrointestinal tumors. Herein, we aim to provide an overview of gene characteristics of Chinese patients with small bowel cancer based on the location of the …

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Case Report: RAB10-ALK: A Novel ALK Fusion in a Patient With Gastric Cancer

Zhengqi Wen, Dun Xiong, Shurong Zhang, Jiankun Liu et autres

Gastric cancer is one of the most common cancers, while the current treatment options for gastric cancer are relatively scarce due to insufficient understanding of molecular characteristics and subtypes of gastric cancer. Different gene rearrangements of anaplastic lymphocyte kinase ( ALK ) …

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The effects of PIK3CA and TP53 on prognosis in patients with Triple-negative breast cancer (TNBC): a single institution’s long-term follow-up (6 years)

Yuan Zhao, Wenru Tang, Limei Sun, Dun Xiong et autres

Application of circulating tumor DNA in breast cancer

Yuan Zhao, Miaomiao Sheng, Ling Zheng, Dun Xiong et autres

Precision medicine has been well recognized since it was proposed, and the invention of liquid biopsy meets the needs of this era. Circulating tumor DNA (ctDNA), one of the most promising components of liquid biopsies, has quickly become the focus of research …

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Factors Predictive of Overall Survival in Metastatic HPV+ Oropharyngeal Cancer: A Multi-Institutional Study

Christopher W. Fleming, M.C. Ward, Neil McIver Woody, Nikhil Purushottam Joshi et autres

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