A. Mayweg

Discovery of 4,5,6,7-Tetrahydropyrazolo[1.5-a]pyrizine Derivatives as Core Protein Allosteric Modulators (CpAMs) for the Inhibition of Hepatitis B Virus

Buyu Kou, Zhisen Zhang, Xingchun Han, Zheng Zhou et autres

cn (code pays fourni par la source)

Discovery of Linvencorvir (RG7907), a Hepatitis B Virus Core Protein Allosteric Modulator, for the Treatment of Chronic HBV Infection

Weixing Zhang, Lei Guo, Haixia Liu, Guolong Wu et autres

cn, ch (code pays fourni par la source)

Abstract LB127: Prospective preclinical modeling to estimate clinical pharmacokinetics and doses of BDTX-189, an inhibitor of allosteric ErbB mutations in advanced solid malignancies

Giorgio Ottaviani, Matthew O’Connor, Alexander Flohr, Darlene Romashko et autres

us (code pays fourni par la source)

Discovery of 3-Pyridyl Isoindolin-1-one Derivatives as Potent, Selective, and Orally Active Aldosterone Synthase (CYP11B2) Inhibitors

Yongfu Liu, Jun Wu, Mingwei Zhou, Wenming Chen et autres

cn, ch (code pays fourni par la source)

CCDC 1963549: Experimental Crystal Structure Determination

Xingchun Han, Chengang Zhou, Min Jiang, Yongguang Wang et autres

CCDC 1963548: Experimental Crystal Structure Determination

Xingchun Han, Chengang Zhou, Min Jiang, Yongguang Wang et autres

EGFR Oncogenes Expressed In Glioblastoma Are Activated As Covalent Dimers And Paradoxically Stimulated By Erlotinib

Matthew J. O’Connor, Jie Zhang, Sandra Marković, Darlene Romashko et autres

us (code pays fourni par la source)

Oncogenic mutations at the dimer interface of EGFR lead to formation of covalent homo-dimers and allosteric activation of the kinase domain: A mechanism which alters the selectivity profile of oncogenic EGFR

Elizabeth Buck, Mathew O'Connor, Alexander Flohr, Roberto Iacone et autres

us, ch (code pays fourni par la source)

Abstract LB-111: Epidermal growth factor receptor oncogenes expressed in glioblastoma are activated as covalent dimers and exhibit unique pharmacology

Matthew O’Connor, Theodore Nicolaides, Jie Zhang, Alexander Flohr et autres

us (code pays fourni par la source)

Abstract LB-111: Epidermal growth factor receptor oncogenes expressed in glioblastoma are activated as covalent dimers and exhibit unique pharmacology

Matthew J. O’Connor, Theodore Nicolaides, Jie Zhang, Alexander Flohr et autres

us (code pays fourni par la source)

Discovery of RG7834: The First-in-Class Selective and Orally Available Small Molecule Hepatitis B Virus Expression Inhibitor with Novel Mechanism of Action

Xingchun Han, Chengang Zhou, Min Jiang, Yongguang Wang et autres

cn, ch (code pays fourni par la source)

Discovery of potent and selective CDK8 inhibitors through FBDD approach

Xingchun Han, Min Jiang, Chengang Zhou, Zheng Zhou et autres

cn (code pays fourni par la source)