А. С. Сенотов

Melatonin enhances the cytotoxicity of etoposide and topotecan against apoptosis-resistant AML cells through modulation of mitochondrial Ca²⁺ and anti-apoptotic BCL-2 family proteins.

A.R. Nosyreva, A. V. Kuzovlev, I.V. Odinokova, E.I. Mescheryakova et autres

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Melatonin enhances the cytotoxicity of etoposide and topotecan against apoptosis-resistant AML cells through modulation of mitochondrial Ca²⁺ and anti-apoptotic BCL-2 family proteins.

A.R. Nosyreva, A. V. Kuzovlev, I.V. Odinokova, E.I. Mescheryakova et autres

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Bioengineered hydrogel-based scaffold for muscle regeneration

M. M. Bobrova, А. L. Luss, П.П. Куликов, I A Fadeeva et autres

Introduction. Injuries, tumor resections, and degenerative diseases can lead to extensive skeletal muscle defects, and consequently, to functional impairment and severe disability. Over the past few decades, various approaches to skeletal muscle tissue engineering have been developed. However, there remains a high …

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Molecular Indicators of Isometric Exercise Efficacy in Early Rehabilitation of Older Adults After Total Hip Arthroplasty

E. F. Maksimova, Kirill S. Krasnov, А. С. Сенотов, Victor I. Shevchenko et autres

Developing molecular methods for assessing the effectiveness of physical rehabilitation remains a pressing task. Our pilot study aimed to assess the utility of the transcriptome analysis of muscle biopsies in evaluating the efficacy of the isometric exercises (IEs) added to the standard …

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Differential Immune Response to Hydroxyapatite Precursors Under Inflammatory Pressure: In Vitro and In Vivo Studies

Irina S. Fadeeva, Anastasia Yu. Teterina, Igor V. Smirnov, Vladislav V. Minaychev et autres

The clinical success of calcium phosphate bone grafts (CPs) largely depends on the body's immune response. However, traditional biocompatibility tests use healthy organisms and cannot predict effectiveness in patients with common chronic inflammatory diseases. This study examines how inflammation modulates the immune …

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Effect of Quizartinib on the Resistance of Acute Myeloid Leukemia Cells with FLT3-ITD-Positive and FLT3-ITD-Negative Phenotypes to the TRAIL-Induced Apoptosis

M. I. Kobyakova, Yana V. Lomovskaya, Kirill S. Krasnov, Irina. V. Odinokova et autres

Abstract Internal tandem duplications in the gene encoding the membrane domain of FLT3 (FLT3-ITD) are the most common genetic alteration and an unfavorable prognostic factor in the patients with acute myeloid leukemia (AML). New-generation FLT3 inhibitors effectively induce cell death in the …

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Western-blots of anti-apoptotic Bcl-2 protein members in THP-1 & MV4-11 cell cultures with and without quizartinib pre-treatment

K. S. Krasnov, A.S. Didenko, I.V. Odinokova, Yana V. Lomovskaya et autres

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Western-blots of anti-apoptotic Bcl-2 protein members in THP-1 & MV4-11 cell cultures with and without quizartinib pre-treatment

K. S. Krasnov, A.S. Didenko, I.V. Odinokova, Yana V. Lomovskaya et autres

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Biotechnological Potential of Terpene Nanoemulsions in Medicine and Agriculture

V. V. Minaychev, M. I. Kobyakova, I. S. Fadeeva, R.S. Fadeev et autres

Abstract Modern biological threats, such as pandemics and zoonotic epidemics, highlight the necessity and importance of strengthening national biosecurity systems and technological sovereignty in healthcare and agriculture. At the same time, current vaccination systems face a number of serious challenges and limitations, …

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Mitochondrial Dysfunction in Apoptosis-Resistant Acute Myeloid Leukemia Cells During a Sterile Inflammatory Response

Е Ю Мещерякова, K. S. Krasnov, Irina V Odinokova, A. I. Lomovsky et autres

Mitochondria are crucial for energy metabolism and the regulation of apoptosis and the inflammatory response in acute myeloid leukemia (AML). This study examined key mitochondrial characteristics in apoptosis-resistant AML cells during in vitro aseptic pro-inflammatory activation utilizing spectrofluorimetry, quantitative reverse transcription PCR, …

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A Biochemical Indicator of the Effectiveness of Isometric Exercises in Early Rehabilitation of Elderly Patients after Hip Arthroplasty

E. A. Maksimova, Vladlena Shevchenko, K. S. Krasnov, А. С. Сенотов et autres

Improving the effectiveness of early rehabilitation of elderly patients after hip arthroplasty remains an urgent task. The aim of the study was to evaluate the effectiveness of isometric exercises in early (2 weeks) rehabilitation of elderly patients after hip replacement using blood …

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Hypercellular Proinflammatory Microenvironment Inhibits the Etoposide-Induced DNA Damage in Acute Monocytic Leukemia Cells

M. I. Kobyakova, K. S. Krasnov, Olga V. Krestinina, Yulia L. Baburina et autres

Abstract Emergence of resistance in acute monocytic leukemia cells (AMoL, AML-M5) to the action of antitumor agents is one of the main reasons for the extremely low survival and curability of the patients diagnosed with AMoL. It is well known that the …

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