G. Cieslewicz

Unrestrained plethysmography is an unreliable measure of airway responsiveness in BALB/c and C57BL/6 mice

Andy Adler, G. Cieslewicz, Charles G. Irvin

There has been significant utilization of the technique described by Hamelmann et al. (Am J Respir Crit Care Med 156: 766-775, 1997) in which a parameter, enhanced pause (Penh), related to airways responsiveness is noninvasively measured by unrestrained plethysmography (UP). Investigating this …

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A Murine IL-4 Receptor Antagonist That Inhibits IL-4- and IL-13-Induced Responses Prevents Antigen-Induced Airway Eosinophilia and Airway Hyperresponsiveness

Adrian Tomkinson, Catherine Duez, G. Cieslewicz, Joanne C. Pratt et autres

The closely related Th2 cytokines, IL-4 and IL-13, share many biological functions that are considered important in the development of allergic airway inflammation and airway hyperresponsiveness (AHR). The overlap of their functions results from the IL-4R alpha-chain forming an important functional signaling …

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Eotaxin-1-Deficient Mice Develop Airway Eosinophilia and Airway Hyperresponsiveness

Adrian Tomkinson, Catherine Duez, G. Cieslewicz, Erwin W. Gelfand

BACKGROUND: The accumulation of eosinophils in the lung is a hallmark of asthma. In addition to cytokines such as IL-5 which are essential, chemokines have been implicated in the recruitment of eosinophils to the airway. In particular, eotaxin has been shown to …

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Announcement

Adrian Tomkinson, Catherine Duez, G. Cieslewicz, Erwin W. Gelfand et autres

Anti-interleukin 5 But Not Anti-IgE Prevents Airway Inflammation and Airway Hyperresponsiveness

Eckard Hamelmann, G. Cieslewicz, Jürgen Schwarze, Tamotsu Ishizuka et autres

The role of IL-5 and allergen-specific IgE in the development of eosinophilic airway inflammation and airway hyperresponsiveness (AHR) was investigated in a murine model. BALB/c mice were sensitized to ovalbumin (OVA) by intraperitoneal injection on Days 1 and 14, followed by airway …

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From Molecular Science to the Treatment of Allergy

Bradley J. Undem, Dawn D. Hunter, Mark Liu, Mary Haak‐Frendscho et autres

Drug DosageThe authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication.However, in view of ongoing research, changes in …

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Subject Index Vol. 118, No. 2–4, 1999

Bradley J. Undem, Dawn D. Hunter, Mark Liu, Mary Haak‐Frendscho et autres

inflammation 90, 200 Allergen(s) 214, 216, 298, 304, 328, 399 -, recombinant 220 -structure 300 Allergic rhinitis 112,

Author and Subject Index Vol. 118, 1999

Bradley J. Undem, Dawn D. Hunter, Mark Liu, Mary Haak‐Frendscho et autres