Ying Feng Zheng

Obstructive sleep apnea and cardiovascular disease in individuals with metabolic dysfunction‐associated fatty liver disease: A prospective cohort study

Haizhen Chen, Ying Feng Zheng, Zhigang Wu, Ningjian Wang et autres

Abstract Objective To assess the association between obstructive sleep apnea (OSA) risk levels and major cardiovascular disease (CVD) subtypes in individuals with metabolic dysfunction‐associated fatty liver disease (MAFLD). Methods This cohort study included 128,022 MAFLD participants from the UK Biobank without CVD …

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(‐)‐Epigallocatechin‐3‐Gallate (EGCG) Regulates the Formation of Zein–Ovalbumin Heteroprotein Complex Coacervates

Min Huang, Jiayi Han, Hao Li, Junhao Lin et autres

Growing interest in sustainable nutrition has improved the importance of understanding the interactions between (‐)‐Epigallocatechin‐3‐gallate (EGCG), a polyphenol in green tea, and proteins for functional food development. In this study, we investigated the regulatory effects of EGCG on the aggregation behavior of …

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RETRACTED ARTICLE: Recent progress in the exploitation of anti-cancer small molecules targeting angiogenesis

Ying Feng Zheng, Hao Qiu, Ke Zhang, Xiang Ji et autres

Angiogenesis is pivotal for cancer growth and metastasis, as tumours rely on new blood vessels to progress and spread. Antiangiogenic drugs represent a crucial therapeutic strategy that combats cancer by both obstructing the development of new blood vessels and disrupting existing tumour-associated …

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Functional diversification of bornyl diphosphate synthase in Lauraceae: An evolutionary framework for borneol-oriented molecular breeding

Qing Ma, Tong Chen, Mei Yang, Wen Xu et autres

Borneol, a bicyclic monoterpenoid with many pharmacological bioactivities and industrial applications, is biosynthesized through bornyl diphosphate synthase (BPPS) belonging to terpene synthase b (TPS-b) clade. While terpenoids are widely distributed in Lauraceae, high-level borneol production is species-specific, characterizing a unique borneol chemotype …

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Exploring syphilis activity for personalized treatment strategies in latent syphilis: a 2-year cohort study

Jia‐Wen Xie, Ya‐Wen Zheng, Shu-Hao Fan, Yinfeng Guo et autres

Background Relying simply on the stage of latent syphilis may lead to excessive treatment strategies. Utilizing nontreponemal immunoglobulin M (IgM) antibodies to assess syphilis activity and tailor treatment strategies may offer enhanced therapeutic advantages. Objectives To investigate whether nontreponemal IgM antibodies can …

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Dual distal insertions drive pimarane-to-miltiradiene rearrangement with enhanced enzymatic activity

Jianing Liu, Jian Wang, Guanghong Cui, Haiyan Zhang et autres

Miltiradiene, the major biosynthetic precursor of abietane diterpenoid natural products, has downstream metabolic derivatives with a significant potential for pharmacologically development. The formation of the characteristic abietane skeleton is attained through the rearrangement of the C13 methyl group in the pimarane intermediate, …

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Abstract 2961: AZD9592, an EGFR/cMET bispecific antibody-drug conjugate (ADC), demonstrates target-dependent efficacy in colorectal cancer (CRC) patient-derived xenograft (PDX) models

Ying Feng Zheng, Edward C. Rosfjord, Simon Christ, Stephanie Zalesak‐Kravec et autres

Abstract Background: AZD9592 is a bispecific ADC designed to target both epidermal growth factor receptor (EGFR) and mesenchymal-epithelial transition tyrosine kinase receptor (cMET), delivering a topoisomerase 1 inhibitor payload to tumor cells. Despite recent advances in ADC development for CRC, such as …

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Stereoselective Synthesis and Mechanism of Bicyclic Iminosugars

Tao Li, Ying Feng Zheng, Lin Guo, Yanping Xie et autres

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Effects of monoclonal antibody daratumumab combined with ixazomib-based treatment regimen on survival of patients with relapsed/refractory multiple myeloma

Lang Peng, Jiawen He, Ying Feng Zheng, Qingfang Zeng

Background/Aim. Combination therapy with daratumumab and ixazomib has been previously used for the treatment of multiple myeloma (MM), but treatment outcomes of these drugs and safety have not yet been confirmed. The aim of the study was to assess the effects of …

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M3Diff:Semantic Mask-Guided 3D Medical Image Synthesis via Mamba-U-Net Hybrid for Data Augmentation

Haixia Pan, Biao Dong, Ruijun Liu, Xueping Wu et autres

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Visual–language foundation models in medicine

Chunyu Liu, Yixiao Jin, Zhouyu Guan, Tingyao Li et autres

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Abstract 2285: Mass spectrometry-based proteomics profiling reveals differential proteome composition in tumor and normal tissues, with implications for normalization

Ying Feng Zheng, Lindsay Olita, M.C. Nivens, Abby J. Chiang et autres

Abstract The composition of the proteome varies significantly across different tissues and disease states creating a challenge of how best to compare expression levels of each protein across these tissue types. Traditionally, a median approach to normalization has been used, but this …

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