Gowtham R. Grandhi

Coronary Artery Calcification and Cardiovascular Events in Familial and Severe Hypercholesterolemia: A Systematic Review and Meta-Analysis

Reed Mszar, M Hiroshi Miname, Craig G. Gunderson, Alyssa A. Grimshaw et autres

Relationship between industry payments to physicians and prescription patterns for PCSK9is, ARNis and DOACs: A report from the NCDR PINNACLE registry

Amarnath Annapureddy, Karthik Murugiah, Luke Zheng, Karl E. Minges et autres

BACKGROUND: We examined the association of industry payments to physicians and prescriptions for proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors, angiotensin receptor-neprilysin inhibitor (ARNi), and direct oral anticoagulants (DOAC). METHODS: Using 2017 data from the NCDR PINNACLE Registry, we idenitifed 3 patient …

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Ventricular Septal Rupture in Cardiac Sarcoidosis Diagnosed by Point-of-Care Ultrasound

Melissa J. Edwards, Christopher Leigh Brown, Gowtham R. Grandhi

A 60-year-old female with cardiac sarcoidosis and a history of ventricular aneurysm presented with acute palpitations and diaphoresis. Bedside point-of-care ultrasound (POCUS) identified a ventricular septal rupture (VSR) with left-to-right shunting, suggesting acute rupture of the aneurysm. This case highlights the critical …

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Abstract 4145899: The Danger of Moderator Band Ectopy: A Case of Premature Ventricular Contraction induced Recurrent Ventricular Fibrillation

Hussein Krayem, Angkawipa Trongtorsak, Gowtham R. Grandhi, Gautham Kalahasty

Introduction: Premature Ventricular Contractions (PVCs) are often a benign arrhythmia. However, those originating from the Purkinje system can result in fatal arrhythmias. One example is PVCs originating from the moderator band (MB) within the right ventricle (RV) of the heart. We present …

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Cardiometabolic outcomes in patients with overweight and obesity undergoing weight loss trials : a network meta-analysis

B.K.H. Tan, Xiaohong Pan, Yik Hin Chin, Cong Cheng et autres

Abstract Objective Cardiometabolic outcomes are intrinsically linked with obesity. According to a study by Jayedi A et al. a 5kg weight gain could increase CVD mortality and MI risk by 11% and 18% respectively, with most overweight and obese patient also suffering …

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Subclinical Atherosclerosis to Guide Treatment in Dyslipidemia and Diabetes Mellitus

Reed Mszar, Miriam E Katz, Gowtham R. Grandhi, Albert Danso Osei et autres

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Efficacy and safety of tirzepatide, GLP ‐1 receptor agonists, and other weight loss drugs in overweight and obesity: a network meta‐analysis

Xin‐Hui Pan, B.C. Tan, Yip Han Chin, Ethan Cheng Zhe Lee et autres

OBJECTIVE: This network meta-analysis evaluates the efficacy and safety of tirzepatide compared to glucagon-like peptide-1 receptor agonists (GLP-1 RA) and other weight loss drugs in the treatment of overweight and obesity. METHODS: MEDLINE, Embase, and Cochrane CENTRAL were searched for randomized controlled …

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Recent advances in cardiovascular risk assessment: The added value of non-invasive anatomic imaging

Pooja V. Selvam, Gowtham R. Grandhi, Thorsten Martin Leucker, Armin Arbab‐Zadeh et autres

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Age- and sex-based heterogeneity in coronary artery plaque presence and burden in familial hypercholesterolemia: A multi-national study

Khurram Nasir, Reed Mszar, Miguel Cainzos‐Achirica, Gowtham R. Grandhi et autres

In general, individuals with familial hypercholesterolemia (FH) are at an increased risk for coronary artery disease (CAD). While prior research has shown variability in coronary artery calcification (CAC) among patients with FH, studies with small sample sizes and single-center recruitment have limited …

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Abstract 12321: Discordant Association of Nonalcoholic Fatty Liver Disease With Lipoprotein(a) and Markers of Atherogenic Dyslipidemia

Terence K. Lee, Gowtham R. Grandhi, Pamela L Alebna, Amon Asgharpour et autres

Background: Nonalcoholic fatty liver disease (NAFLD) is associated with atherogenic dyslipidemia and an increased risk of cardiovascular events. Previous studies have suggested a paradoxical inverse relationship between NAFLD severity and Lp(a) level, an independent cardiovascular risk factor. However, contemporary data in patients …

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Abstract 16491: The Relationship Between Cardiovascular Health and 10-year Atherosclerotic Cardiovascular Risk in American Adults

Gowtham R. Grandhi, Pamela L Alebna, Joaquín I. Armendano, Erfan Tasdighi et autres

Introduction: Life’s Essential 8 (LE8) is a metric of overall cardiovascular health (CVH) while 10-year atherosclerotic cardiovascular disease (ASCVD) risk is routinely used to guide primary prevention. Yet, the relationship between LE8 and 10-year ASCVD risk is unclear. Hypothesis: CVH has an …

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Abstract 15562: Coronary Artery Calcium Score for Allocating Emerging Obesity Therapies: Implications for the Ongoing SURMOUNT-MMO Outcome Trial

Erfan Tasdighi, Gowtham R. Grandhi, Ellen Boakye, Michael Joseph Blaha

Background: Tirzepatide demonstrated substantial weight loss in patients with obesity yet without diabetes and the clinical trial (SURMOUNT-MMO) evaluating its CVD benefits is ongoing. We tested whether the CAC score provides substantial risk predictive value in this setting. Methods: Participants (N=16,163; mean …

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