Varsha Parthasarathy

Somatic mutations reveal hyperactive Notch signaling in prurigo nodularis

Ahmad Rajeh, Shahin Shahsavari, Hannah Cornman, Alexander Kollhoff et autres

Prurigo nodularis (PN) is a chronic inflammatory skin disease characterized by pruritic skin nodules of unknown etiology. Little is known about genetic changes in PN pathogenesis, particularly somatic events, which are often implicated in inflammatory conditions. We thus performed whole-exome sequencing on …

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Targeted dual biologic therapy for erythroderma of unknown etiology guided by high-parameter peripheral blood immunophenotyping

Hannah Cornman, Martin P. Alphonse, Arbor G. Dykema, Alexander Kollhoff et autres

Erythroderma is a severe and heterogeneous inflammatory skin condition with little guidance on the approach to management in cases of unknown etiology. To guide therapeutic selection, we sought to create an immunophenotyping platform able to identify aberrant cell populations and cytokines in …

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Elevated C-reactive protein levels and cardiovascular risk in prurigo nodularis patients with sleep disturbance: a multi-center cohort study

Emily Ma, Varsha Parthasarathy, Kevin K. Lee, Shahin Shahsavari et autres

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Risk factors and temporal associations of progression of the atopic march in children with early-onset atopic dermatitis

Una Choi, Junwen Deng, Varsha Parthasarathy, Viviane Liao et autres

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52495 Elevated C-reactive protein levels in older adults with itch is associated with incident comorbidities and mortality: a multicenter cohort study

Jaya Manjunath, Varsha Parthasarathy, Kevin K. Lee, Brenda Umenita Imo et autres

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Plasma metabolomic profiling reveals a novel circulating biomarker signature in chronic pruritus of unknown origin

Jaya Manjunath, Varsha Parthasarathy, Marina Z. Joel, Junwen Deng et autres

Chronic pruritus of unknown origin (CPUO) is characterized by chronic itch for 6 weeks or greater without an identifiable primary cause. Studies are needed to investigate circulating blood biomarkers to elucidate disease pathogenesis. The objective of this study was to investigate changes …

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Efficacy and Safety of Abrocitinib in Prurigo Nodularis and Chronic Pruritus of Unknown Origin

Shawn G. Kwatra, Zachary A. Bordeaux, Varsha Parthasarathy, Alexander Kollhoff et autres

Importance: Prurigo nodularis (PN) and chronic pruritus of unknown origin (CPUO) are chronic pruritic diseases that dramatically impair quality of life, but therapeutic options are limited. Abrocitinib, a Janus kinase 1 inhibitor, represents a promising therapy for both conditions. Objective: To assess …

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Spatial Mass Cytometry–Based Single-Cell Imaging Reveals a Disrupted Epithelial–Immune Axis in Prurigo Nodularis

Junwen Deng, Anusha Kambala, Kevin K. Lee, Hannah Cornman et autres

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Prevalence of prurigo nodularis in the United States

Shawn G. Kwatra, Jorge Puelles, Oth Tran, Matthew Brouillette et autres

To the Editor: Prurigo nodularis (PN) is a rare chronic inflammatory skin condition characterized by severe itch. Although the National Organization for Rare Diseases and Genetic and Rare Disease Information Center classifies PN as a rare disease,1 there is a paucity of …

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Integrated plasma metabolomic and cytokine analysis reveals a distinct immunometabolic signature in atopic dermatitis

Emily Ma, Junwen Deng, Varsha Parthasarathy, Kevin K. Lee et autres

Importance: Disease models for atopic dermatitis (AD) have primarily focused on understanding underlying environmental, immunologic, and genetic etiologies. However, the role of metabolic mechanisms in AD remains understudied. Objective: To investigate the circulating blood metabolomic and cytokine profile of AD as compared …

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Single-Cell RNA Sequencing Reveals Dysregulated POSTN+WNT5A+ Fibroblast Subclusters in Prurigo Nodularis

Marina Z. Joel, Kevin K. Lee, Anusha Kambala, Hannah Cornman et autres

Prurigo nodularis (PN) is an intensely pruritic, inflammatory skin disease with a poorly understood pathogenesis. We performed single-cell transcriptomic profiling of 28,695 lesional and nonlesional PN cells. Lesional PN has increased dysregulated fibroblasts (FBs) and myofibroblasts. FBs in lesional PN were shifted …

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Somatic mutations reveal hyperactive Notch signaling and racial disparities in prurigo nodularis

Ahmad Rajeh, Hannah Cornman, Anuj Gupta, Mindy D Szeto et autres

Abstract Prurigo nodularis (PN) is a chronic inflammatory skin disease that disproportionately affects African Americans and is characterized by pruritic skin nodules of unknown etiology. Little is known about genetic alterations in PN pathogenesis, especially relating to somatic events which are often …

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