Hyoung Kyu Kim

SGLT2 inhibitors as modulators of mitochondrial ion transport and ER-mitochondria cross talk in diabetic cardiomyopathy

Jessa Flores, Maria Victoria Faith Garcia, Prycelline Abedejos, Jed Allyn Hernandez et autres

Diabetic cardiomyopathy (DCM) is a major complication of type 2 diabetes mellitus and a leading contributor to heart failure. A central feature of DCM is the disruption of mitochondrial bioenergetics and calcium homeostasis, processes that are tightly regulated through mitochondria-associated endoplasmic reticulum …

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Subacute Hypoxia Induces Cardiac Remodeling and Mitochondrial Dysfunction via Apoptotic Pathways in a Rabbit Model of Tracheal Stenosis

Taeyun Kim, Kyoung Im Cho, Hyoung Kyu Kim, Chulho Oak et autres

Myocardial hypoxia is a major cause of cardiac dysfunction, triggering cellular injury and apoptosis. This study aims to investigate the effects of subacute hypoxia on cardiac remodeling and mitochondrial oxygen consumption. This study is based on a rabbit experimental model. Hypoxia was …

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Echinochrome A inhibits epithelial–mesenchymal transition and induces cell death mediated by DNA damage in human triple-negative breast cancer cells

Soon Yong Park, Mi-So Jeong, Cong So Tran, Jin‐Young Lee et autres

Echinochrome A (Ech A), a marine-derived compound from Scaphechinus mirabilis , is known for its potent antioxidant activity. Its pharmacological derivative, Histochrome, is used to treat ischemia and cardiovascular disorders. Triple-negative breast cancer (TNBC) is an aggressive subtype with poor prognosis and …

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Abstract Wed146: Generation and characterization of induced pluripotent stem cell-derived cardiomyocytes from uncontrolled diabetic patients with ischemic and non-ischemic cardiomyopathy

Sung Woo Cho, Hyoung Kyu Kim, Jin Han, Yun‐Gwi Park et autres

Diabetes mellitus is an important risk factor for coronary artery disease, heart failure, and cardiomyopathy, contributing to atherosclerosis as well as structural and functional cardiac changes. Patient-specific induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) hold great potential for investigating cellular mechanisms and serving …

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Cereblon upregulation overcomes thalidomide resistance in multiple myeloma through mitochondrial functional reprogramming

Jubert Marquez, Nammi Park, Jae Hyeog Choi, Maria Victoria Faith Garcia et autres

Jubert Marquez, Nammi Park, Jae Hyeog Choi, Maria Victoria Faith Garcia, Jessa Flores, Bayalagmaa Nyamaa, Jung Eun Seol, Hyoung Kyu Kim, Myung Geun Shin, Sae Gwang Park & Jin Han. BMB Reports -0001;0:. https://doi.org/10.5483/BMBRep.2024-0130

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Is Shank3 a ‘Friend or Foe’ of the Heart? Its Role in Cardiac Calcium Homeostasis

Hyoung Kyu Kim, Jin Han

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Evaluation of the cardiotoxicity of Echinochrome A using human induced pluripotent stem cell-derived cardiac organoids

Su-Jin Lee, Eunji Kim, Yeeun Jeong, Jae Boum Youm et autres

Echinochrome A (EchA), a marine-derived natural product, has shown promise in treating cardiovascular and inflammatory diseases due to its antioxidant and anti-inflammatory properties. However, its cardiac safety remains underexplored. In this study, we utilized human induced pluripotent stem cell-derived cardiac organoids (hCOs) …

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Abstract Mo048: Cereblon as a potential biomarker for early detection of diabetic cardiomyopathy

Sung Woo Cho, Hyoung Kyu Kim, Byung Gyu Kim, Jin H. Han

Type 2 diabetes mellitus (T2DM) patients have a higher risk of heart failure and cause cardiomyopathy without other cardiac disease. There is no specific biomarker for discriminating patients with diabetic cardiomyopathy (DCM). In this study, we investigated the cereblon (CRBN) level in …

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Corrigendum to: Cardioprotection via mitochondrial transplantation supports fatty acid metabolism in ischemia-reperfusion injured rat heart

Jehee Jang, Ki‐Woon Kang, Youngwon Kim, Seohyun Jeong et autres

Jehee Jang, Ki-Woon Kang, Young-Won Kim, Seohyun Jeong, Jaeyoon Park, Jihoon Park, Jisung Moon, Junghyun Jang, Seohyeon Kim, Sunghun Kim, Sungjoo Cho, Yurim Lee, Hyoung Kyu Kim, Jin Han, Eun-A Ko, Sung-Cherl Jung, Jung-Ha Kim, and Jae-Hong Ko. Korean J Physiol Pharmacol …

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Cardioprotection via mitochondrial transplantation supports fatty acid metabolism in ischemia-reperfusion injured rat heart

Jehee Jang, Ki‐Woon Kang, Youngwon Kim, Seohyun Jeong et autres

Jehee Jang, Ki-Woon Kang, Young-Won Kim, Seohyun Jeong, Jaeyoon Park, Jihoon Park, Jisung Moon, Junghyun Jang, Seohyeon Kim, Sunghun Kim, Sungjoo Cho, Yurim Lee, Hyoung Kyu Kim, Jin Han, Eun-A Ko, Sung-Cherl Jung, Jung-Ha Kim, and Jae-Hong Ko. Korean J Physiol Pharmacol …

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Cereblon-mediated TRPC1 degradation regulates Ca2+ influx in the heart

Nammi Park, Jubert Marquez, Nguyen Thi Tuyet Anh, Jessa Flores et autres

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Corrigendum to “Neopetroside-B alleviates doxorubicin-induced cardiotoxicity via mitochondrial protection” [Biomed. Pharmacother. 165 (2023) 115232]

Chang Shin Yoon, Nikolay E. Nifantiev, Dmitry V. Yashunsky, Hyoung Kyu Kim et autres

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