Giulio Viceconte

Association of undernutrition and tuberculosis outcomes: a retrospective multicentre cohort study in Italy

Francesco Di Gennaro, Giacomo Guido, Gina Gualano, Alessandro Cornelli et autres

Objectives Undernutrition remains one of the most powerful yet neglected determinants of tuberculosis (TB) incidence and progression. While its impact on TB outcomes has been extensively described in low-income countries, limited evidence is available from high-income settings. This study aimed to assess …

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Persistent candidemia - a systematic review and meta-analysis on risk factors and outcomes v1

Dr.Alberto Enrico Maraolo, Francesco Di Gennaro, Roberta Astorri, Giulio Viceconte et autres

Persistent candidemia represents a clinically relevant yet underexplored condition defined as the continued isolation of the same Candida species from blood cultures usually ≥5 days after initiation of active antifungal therapy. Nevertheless, there are some relevant knowledge gaps: 1. Lack of consensus …

Sex disparities in tuberculosis outcomes: evidence from a multicenter Italian cohort (Italian South TB Network (ISTB-Net)

Francesco Di Gennaro, Alessandro Cornelli, Giacomo Guido, Rosa Buonamassa et autres

BACKGROUND: Sex disparities in tuberculosis (TB) outcomes are not well characterized, especially in high-income countries where social vulnerability and migration influence access to care. Although men globally experience a higher TB burden, the interaction between sex, migration, and social determinants is complex …

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Sex disparities in tuberculosis outcomes: evidence from a multicenter Italian cohort (Italian South TB Network (ISTB‐Net)

Francesco Di Gennaro, Alessandro Cornelli, Giacomo Guido, Rosa Buonamassa et autres

Abstract Background Sex disparities in tuberculosis (TB) outcomes are not well characterized, especially in high-income countries where social vulnerability and migration influence access to care. Although men globally experience a higher TB burden, the interaction between sex, migration, and social determinants is …

Activity of sotrovimab in early clearance of SARS CoV-2 infection in severe immunocompromised patients: results of a prospective, monocentric study

Giulio Viceconte, Antonio Riccardo Buonomo, Emilia Trucillo, Alessia D’Agostino et autres

Background The combination of antivirals and monoclonal antibodies (mAbs) in the first phase of COVID-19 has demonstrated to reduce time to viral clearance, but the superiority of combination compared to antiviral monotherapy is still debated.Research design and methods In an observational, prospective …

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Outbreak of Human Neuroinvasive West Nile Virus Infection in Campania, Italy, August–September 2024

Nunzia Di Palma Esposito, Giulio Viceconte, Lidia Festa, Francesco Antimo Alfè et autres

Background: West Nile Virus (WNV) infection is endemic in Italy, but it has rarely reported in humans in Southern Italy. We report the first human outbreak of WNV infection in the Campania region, Italy. Results: Five confirmed and seven probable cases of …

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The role of rapid and advanced microbiological methods in critical care: 2025 Emanuele Russo Delphi consensus

Vittorio Sambri, Vanni Agnoletti, Simone Ambretti, Michele Bartoletti et autres

SCOPE: Interpretation of rapid and advanced microbiological test results remains nonstandardized, with no existing reference guidelines. This study aimed to analyse the existing evidence and provide expert guidance on the use of these techniques in critically ill patients. METHODS: A Delphi consensus …

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Caspofungin for Primary Antifungal Prophylaxis in Acute Myeloid Leukemia: A Real-Life Study from an Academic Center

Francesco Grimaldi, Mara Memoli, Simona Avilia, Carlangela Causa et autres

Background: Invasive fungal infections (IFIs) are a major complication in patients with acute myeloid leukemia (AML), particularly during chemotherapy-induced neutropenia. Posaconazole is the standard drug for primary antifungal prophylaxis (PAP), but its use is limited by oral bioavailability and CYP3A4 interactions. Study …

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Caspofungin for Primary Antifungal Prophylaxis in Acute Myeloid Leukemia: A Real-Life Study from an Academic Center

Francesco Grimaldi, Mara Memoli, Simona Avilia, Carlangela Causa et autres

Background: Invasive fungal infections (IFIs) are a major complication in patients with Acute Myeloid Leukemia (AML), particularly during chemotherapy-induced neutropenia. Posaconazole is the standard drug for primary antifungal prophylaxis (PAP), but its use is limited by oral bioavailability and CYP3A4 interactions. To …

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Correction: Efficacy of Nirmatrelvir/ritonavir in reducing the risk of severe outcome in patients with SARS-CoV-2 infection: a real-life full-matched case–control study (SAVALO Study)

Ivan Gentile, Agnese Giaccone, Maria Michela Scirocco, Francesco Brizzi et autres

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Management of hepatitis B virus (HBV) infection in multiple sclerosis patients on disease modifying therapies (DMTs)

Antonio Riccardo Buonomo, Giulio Viceconte, Laura Ambra Nicolini, Selma Habibović et autres

Disease-modifying therapies (DMTs) for multiple sclerosis (MS) can increase the risk of hepatitis B virus (HBV) reactivation (HBr), particularly with agents like ocrelizumab and alemtuzumab. However, studies in MS patients treated with DMTs indicate significantly lower reactivation rates compared to those with …

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Toxoplasma Gondii Replication During Belatacept Treatment in Kidney Transplantation: A Case Report and a Review of the Literature

Raffaella Vigilante, Raafiah Izhar, Rossella Di Paola, Ananya De et autres

Belatacept is a chimeric protein that acts as a selective blocker of T-lymphocyte co-stimulation. It has been proposed for the prevention of kidney transplant rejection. This paper reports a literature review on pharmacological characteristics of belatacept and genetic factors influencing its efficacy …

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