Jacky Bonaventure

KIAA1217/SKT and its paralog p140Cap are centrosomal proteins that regulate ciliogenesis through Src family signaling pathway

Logan Greibill, Lucie Raimbourg, Hugo Siegfried, Jacky Bonaventure et autres

ABSTRACT Centrosomes organize the microtubule network along the cell cycle and drive cilia assembly in resting cells to allow sensory or motility functions. Defects in cilia formation underlie ciliopathies and skeletal disorders, but the molecular regulators that couple centrosomes to signaling and …

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Supplementary Movie 5 from β-Catenin Inhibitor ICAT Modulates the Invasive Motility of Melanoma Cells

Mélanie J. Domingues, Florian Rambow, Bastien Job, Laura Papon et autres

MP4 file - 2929K, Supplementary movie S5: time-lapse video-microscopy with a 10x magnification objective, of Mel501 cells plated on plastic 48 hr after si ICAT transfection.

Supplementary Figure 3 from β-Catenin Inhibitor ICAT Modulates the Invasive Motility of Melanoma Cells

Mélanie J. Domingues, Florian Rambow, Bastien Job, Laura Papon et autres

PDF file - 114K, ICAT DQE mutant does not bind to b-catenin.

Supplementary Movie 3 from β-Catenin Inhibitor ICAT Modulates the Invasive Motility of Melanoma Cells

Mélanie J. Domingues, Florian Rambow, Bastien Job, Laura Papon et autres

MP4 file - 3337K, Supplementary movie S3: time-lapse video-microscopy with a 10x magnification objective, of Lu1205 cells plated on plastic 48 hr after MOCK transfection.

Data from β-Catenin Inhibitor ICAT Modulates the Invasive Motility of Melanoma Cells

Mélanie J. Domingues, Florian Rambow, Bastien Job, Laura Papon et autres

Abstract Inhibitor of β-catenin and TCF (ICAT) inhibits β-catenin transcriptional activity by competing with T-cell factor/lymphoid enhancer factor. We documented high ICAT levels in human melanoma cells, in which β-catenin signaling is frequently deregulated, finding a correlation with the capacity to form …

Supplementary Figure 4 from β-Catenin Inhibitor ICAT Modulates the Invasive Motility of Melanoma Cells

Mélanie J. Domingues, Florian Rambow, Bastien Job, Laura Papon et autres

PDF file - 234K, Stable exogenous ICAT expression increases Lu1205 and Mel501 cell lines migration.

Supplementary Figure 9 from β-Catenin Inhibitor ICAT Modulates the Invasive Motility of Melanoma Cells

Mélanie J. Domingues, Florian Rambow, Bastien Job, Laura Papon et autres

PDF file - 218K, Un-cropped immunoblot images. Original images used to generate panels in Figures 6, 7, S3 and S5.

Supplementary Movie 4 from β-Catenin Inhibitor ICAT Modulates the Invasive Motility of Melanoma Cells

Mélanie J. Domingues, Florian Rambow, Bastien Job, Laura Papon et autres

MP4 file - 1786K, Supplementary movie S4: time-lapse video-microscopy with a 10x magnification objective, of Lu1205 cells plated on plastic 48 hr after ICAT transfection.

Supplementary Figure 5 from β-Catenin Inhibitor ICAT Modulates the Invasive Motility of Melanoma Cells

Mélanie J. Domingues, Florian Rambow, Bastien Job, Laura Papon et autres

PDF file - 147K, Exogenous ICAT expression does not affect the morphology of Mel501 and Skmel3 cells.

Supplementary Movie 6 from β-Catenin Inhibitor ICAT Modulates the Invasive Motility of Melanoma Cells

Mélanie J. Domingues, Florian Rambow, Bastien Job, Laura Papon et autres

MP4 file - 1833K, Supplementary movie S6: time-lapse video-microscopy with a 10x magnification objective, of Lu1205 cells plated on plastic 48 hr after si ICAT transfection.

Supplementary Movie 2 from β-Catenin Inhibitor ICAT Modulates the Invasive Motility of Melanoma Cells

Mélanie J. Domingues, Florian Rambow, Bastien Job, Laura Papon et autres

MP4 file - 3502K, Supplementary movie S2: time-lapse video-microscopy with a 10x magnification objective, of Mel501 cells plated on plastic 48 hr after ICAT transfection.

Supplementary Figure 7 from β-Catenin Inhibitor ICAT Modulates the Invasive Motility of Melanoma Cells

Mélanie J. Domingues, Florian Rambow, Bastien Job, Laura Papon et autres

PDF file - 67K, (A) Heatmap representation of ICAT/CTNNBIP1 levels and unsupervised hierarchical clustering based on transcriptomic analysis of ICAT/CTNNBIP1 expression in 22 human melanoma metastases (31). (B) Significant decrease of median Distant Metastasis Free Survival (DMFS) time in cluster 1 (8 …