Kentaro Ido

Comprehensive analysis of transient elastography, ultrasonography, and blood biomarkers in SOS diagnosis and prediction

Naonori Harada, Hiroshi Okamura, Hideo Koh, Koji Abo et autres

Sinusoidal obstruction syndrome (SOS) is a potentially fatal complication following allogeneic hematopoietic cell transplantation (allo-HCT). The Seattle and Baltimore criteria are widely used for diagnosing SOS, but both have limitations in terms of sensitivity and positive predictive value. While liver biopsy provides …

jp (code pays fourni par la source)

Donor selection for allogeneic hematopoietic cell transplantation in the posttransplant cyclophosphamide era

Kentaro Ido, Hirohisa Nakamae

jp (code pays fourni par la source)

CD66c expression is an important factor in adult B-cell acute lymphoblastic leukemia

Mai Kawazoe, Yasuhiro Nakashima, Soichiro Nakako, Makoto Moriguchi et autres

Abstract In B-cell acute lymphoblastic leukemia (B-ALL), a measurable residual disease (MRD) level of <0.01% after remission induction therapy is an important prognostic factor. Regardless of the timing of measurement, the lower the MRD, the better the prognosis; however, the risk of …

jp (code pays fourni par la source)

Outcomes of relapsed or refractory mature T/NK-cell lymphomas in the era of novel agents: A nationwide observational Study in Japan

Hideki Uryu, Tsuyoshi Muta, Mitsumasa Watanabe, Kosei Matsue et autres

Abstract Background: Mature T-cell and natural killer-cell lymphomas (MTNKLs) are often refractory to conventional treatment and associated with a poor prognosis. Between March 2014 and March 2024, nine novel agents were approved in Japan as single agents (SAs) for relapsed or refractory …

jp, de, us (code pays fourni par la source)

Mogamulizumab Concentration-guided Allogeneic Transplantation and Successful Intrathecal Chemotherapy for Central Nervous System-relapsed Adult T-cell Leukemia/Lymphoma

Saki Fujii, Kazuki Sakatoku, Yosuke Nakaya, Mirei Horiuchi et autres

Adult T-cell leukemia/lymphoma (ATL) has a poor prognosis, with mogamulizumab effectively controlling the disease but increasing graft-versus-host disease (GVHD) risk during transplantation if residual levels persist. We herein report a 61-year-old patient with acute-type ATL who underwent mogamulizumab concentration-guided transplantation to avoid …

jp (code pays fourni par la source)

Efficacy of ibrutinib and diagnostic liver biopsy for idiopathic refractory ascites after allogeneic stem cell transplantation

Kazuki Sakatoku, Masanori Shiohara, Yosuke Nakaya, Mirei Horiuchi et autres

jp (code pays fourni par la source)

Effects of routes, concentrations and genetic polymorphisms on posaconazole–tacrolimus interactions in allogeneic haematopoietic cell transplantation

Masatomo Kuno, Yusuke Okayama, Yukako Yasui, Wataru Shibata et autres

There is no prospective research on factors influencing posaconazole (PSCZ)-tacrolimus (TAC) interactions. This prospective observational study analysed 30 allogeneic haematopoietic cell transplantation recipients: 19 started PSCZ while receiving oral (n = 10) or intravenous (IV) TAC (n = 9) and 11 switched …

jp (code pays fourni par la source)

Comparison of Clinician and Machine Learning Predictions of Allo-HCT Prognosis: A Prospective Observational Study

Soichiro Nakako, Hiroshi Okamura, Makoto Moriguchi, Kentaro Ido et autres

Introduction Recently, the performance of data-driven personalized prognostic prediction using machine learning models has been reported in the field of allogeneic hematopoietic stem cell transplantation (allo-HCT). However, it remains unclear which prediction is superior between the machine learning model and clinicians. Objective …

jp (code pays fourni par la source)

Higher Graft CD4+ T Cell and B Cell Counts Reduce Relapse Risk in Haploidentical Peripheral Blood Stem Cell Transplantation with Posttransplant Cyclophosphamide

Makoto Moriguchi, Soichiro Nakako, Kentaro Ido, Kazuki Sakatoku et autres

Introduction Haploidentical hematopoietic stem cell transplantation (Haplo-HCT) with post-transplant cyclophosphamide (PTCy) has emerged as a viable option for patients with hematologic malignancies who lack HLA-matched donors. Although several studies have suggested that the composition of lymphocyte subsets in donor grafts might influence …

jp (code pays fourni par la source)

The Diagnostic Accuracy of the Refined EBMT Criteria 2023 for SOS

Hiroshi Okamura, Soichiro Nakako, Makoto Moriguchi, Kentaro Ido et autres

Introduction： Sinusoidal obstruction syndrome (SOS) is a rare but serious complication of allogeneic hematopoietic stem cell transplantation (allo-HSCT). An early diagnosis and intervention are crucial to improve patient outcomes. The gold standard for the diagnosis is a liver biopsy, but this can …

jp (code pays fourni par la source)

A case of posttransplant isolated extramedullary relapse of acute lymphoblastic leukemia achieving durable treatment-free remission with blinatumomab and donor lymphocyte infusion

Makoto Nishijima, Kentaro Ido, Yusuke Okayama, Hiroshi Okamura et autres

jp (code pays fourni par la source)

Dynamic Relapse Prediction by Peripheral Blood WT1mRNA after Allogeneic Hematopoietic Cell Transplantation for Myeloid Neoplasms

Soichiro Nakako, Hiroshi Okamura, Isao Yokota, Yukari Umemoto et autres

Although various relapse prediction models based on pretransplant information have been reported, they cannot update the predictive probability considering post-transplant patient status. Therefore, these models are not appropriate for deciding on treatment adjustment and preemptive intervention during post-transplant follow-up. A dynamic prediction …

jp (code pays fourni par la source)