Daniela Conticelli

A multilayered in silico analysis links UHRF1, DNA methylation and developmental chromatin memory to lineage-dependent prognosis in gastric, renal and adrenal cancers

Jacopo Biotti, Livio Muccillo, Filippo Macchi, Marco Spadarotto et autres

Abstract Aberrant DNA methylation is a hallmark of cancer, but its clinical interpretation remains debated. UHRF1, a key epigenetic adaptor for DNA methylation maintenance and chromatin bivalency regulation in embryonic stem cells, is frequently overexpressed yet shows context-dependent prognostic behaviour. By integrating …

it, ae (code pays fourni par la source)

Table S2 from Novel WRN Helicase Inhibitors Selectively Target Microsatellite-Unstable Cancer Cells

Gabriele Picco, Yanhua Rao, Angham Al Saedi, Yang Lee et autres

This table lists the results from Base editing screen

Table S3 from Novel WRN Helicase Inhibitors Selectively Target Microsatellite-Unstable Cancer Cells

Gabriele Picco, Yanhua Rao, Angham Al Saedi, Yang Lee et autres

This file contain information on the Cell lines and organoids used in this study

Table S1 from Novel WRN Helicase Inhibitors Selectively Target Microsatellite-Unstable Cancer Cells

Gabriele Picco, Yanhua Rao, Angham Al Saedi, Yang Lee et autres

This file contains details of the BE sgRNA library

Abstract 7504: Do secondary MSH3/MSH6 alterations define an immune-modulatory subtype of MSI gastric cancer

Marika Milan, Daniela Conticelli, Marco Volante, Claudia Orrù et autres

Abstract Gastric cancer (GC) is one of the leading causes of cancer-related morbidity and mortality worldwide. Molecular classification stratifies GC into four major subtypes: Epstein-Barr virus-positive, microsatellite instability (MSI), genomically stable, and chromosomal instability. Among these, MSI GC—representing approximately 8-25% of cases—is …

it (code pays fourni par la source)

danic-biores/organoid-macro-ijm: Initial release

Daniela Conticelli, Marika Milan

First version of the ImageJ/Fiji macro for automated organoid segmentation and growth analysis

danic-biores/organoid-macro-ijm: Initial release

Daniela Conticelli, Marika Milan

First version of the ImageJ/Fiji macro for automated organoid segmentation and growth analysis

Figure S1 from BRCA2 Germline Mutations Identify Gastric Cancers Responsive to PARP Inhibitors

Annalisa Petrelli, Sabrina Rizzolio, Filippo Pietrantonio, Sara E. Bellomo et autres

HR gene mutations in GEA models used in in vitro and in vivo experiments.

Supplementary Table S2 from BRCA2 Germline Mutations Identify Gastric Cancers Responsive to PARP Inhibitors

Annalisa Petrelli, Sabrina Rizzolio, Filippo Pietrantonio, Sara E. Bellomo et autres

Molecular, histological and pathological features of the 57 metastatic gastric cancer patients included in the retrospective analysis

Supplementary Methods from BRCA2 Germline Mutations Identify Gastric Cancers Responsive to PARP Inhibitors

Annalisa Petrelli, Sabrina Rizzolio, Filippo Pietrantonio, Sara E. Bellomo et autres

Supplementary Methods

Figure S8 from BRCA2 Germline Mutations Identify Gastric Cancers Responsive to PARP Inhibitors

Annalisa Petrelli, Sabrina Rizzolio, Filippo Pietrantonio, Sara E. Bellomo et autres

RAD51 assay predicts PARPi response in Gastric Cancer PDX models.

Supplementary Table S3 from BRCA2 Germline Mutations Identify Gastric Cancers Responsive to PARP Inhibitors

Annalisa Petrelli, Sabrina Rizzolio, Filippo Pietrantonio, Sara E. Bellomo et autres

LOF mutations and clinical characteristics of patients carrying HR gene variants