Da Zhai

NMN alleviates oxidative stress damage in alopecia areata by activating SIRT7 and promoting glutamine metabolism

Tianyu Cao, Lan Jiang, Lu Liu, Na Wang et autres

cn (code pays fourni par la source)

Hydrostatic pressure activates HIF ‐1α via β‐catenin to promote stemness in breast cancer cells

Da Zhai, Yong Xu, Jingjing Ma, Ratchanee Duangrat et autres

Tumor microenvironment plays a pivotal role in regulating the biological properties of cancer cells. Interstitial fluid hydrostatic pressure (HP) generally increases in malignant solid tumors. While our recent work has demonstrated that elevated HP stabilizes HIF‐1α expression in cancer cells, here we …

cn, jp, th (code pays fourni par la source)

Author response for "Hydrostatic pressure activates HIF-1α via β-catenin to promote stemness in breast cancer cells"

Da Zhai, Yong Xu, Jingjing Ma, Ratchanee Duangrat et autres

Nanozymes for ATP/cAMP balance restoration and ROS scavenging in inflammatory dermatosis treatment and recurrence prevention

Xiaolei Su, Jiahao Ma, Zhenhua Liu, YaoYao Li et autres

Inflammatory dermatoses like psoriasis and atopic dermatitis are prevalent autoimmune disorders whose management is challenged not only by inflammatory lesions but, more significantly, by persistent pruritus and frequent relapse following treatment discontinuation. The pathogenic progression of these dermatoses is critically influenced by …

cn (code pays fourni par la source)

POU4F1 Promotes the Primary Resistance of Melanoma to Anti‐PD‐1 Therapy by Regulating Glycolysis Through METTL1‐Mediated m7G Methylation of PKM2

Lin Liu, Xiao‐Kang Li, Xinhong Hu, Da Zhai et autres

ABSTRACT Melanoma, a highly malignant tumor originating from melanocytes, has seen a significant increase in global incidence, particularly among the elderly. Anti‐PD‐1 monoclonal antibodies, which activate the immune system to attack cancer cells by blocking the PD‐1/PD‐L1 signaling pathway, have improved survival …

cn (code pays fourni par la source)

Hyperoxia but not high tidal volume contributes to ventilator-induced lung injury in healthy mice

Yong Xu, Yu Li, Da Zhai, Yan Chen et autres

Abstract Background Mechanical ventilation is a supportive therapy used to maintain respiratory function in several clinical and surgical cases but is always accompanied by lung injury risk due to improper treatment. We investigated how tidal volume and oxygen delivery would contribute independently …

jp, cn (code pays fourni par la source)

Author response for "Optimization on the dose and time of nicaraven administration for mitigating the side effects of radiotherapy in a preclinical tumor-bearing mouse model"

Yong Xu, Lina Abdelghany, Reiko Sekiya, Da Zhai et autres

Ex Vivo Hydrostatic Pressure Loading of Atrial Tissues Activates Profibrotic Transcription via TGF-β Signal Pathway

Xu Zhang, Mhd Yousuf Yassouf, Kai Huang, Yong Xu et autres

Excessive mechanical stress causes fibrosis-related atrial arrhythmia. Herein, we tried to investigate the mechanism of atrial fibrogenesis in response to mechanical stress by ex vivo approach. We collected atrial tissues from mice and then cultured them as "explants" under atmospheric pressure (AP …

jp, cn (code pays fourni par la source)

Optimization on the dose and time of nicaraven administration for mitigating the side effects of radiotherapy in a preclinical tumor-bearing mouse model

Yong Xu, Lina Abdelghany, Reiko Sekiya, Da Zhai et autres

OBJECTIVE: Radiation-induced lung injury (RILI) is one of the serious complications of radiotherapy. We have recently demonstrated that nicaraven can effectively mitigate RILI in healthy mice. Here, we further tried to optimize the dose and time of nicaraven administration for alleviating the …

jp (code pays fourni par la source)

Nicaraven mitigates radiation-induced lung injury by downregulating the NF-κB and TGF-β/Smad pathways to suppress the inflammatory response

Yong Xu, Da Zhai, Shinji Goto, Xu Zhang et autres

Radiation-induced lung injury (RILI) is commonly observed in patients receiving radiotherapy, and clinical prevention and treatment remain difficult. We investigated the effect and mechanism of nicaraven for mitigating RILI. C57BL/6 N mice (12-week-old) were treated daily with 6 Gy X-ray thoracic radiation …

jp (code pays fourni par la source)

Biphasic effect of mechanical stress on lymphocyte activation

Mhd Yousuf Yassouf, Xu Zhang, Zisheng Huang, Da Zhai et autres

Mechanical forces can modulate the immune response, mostly described as promoting the activation of immune cells, but the role and mechanism of pathological levels of mechanical stress in lymphocyte activation have not been focused on before. By an ex vivo experimental approach, …

jp (code pays fourni par la source)

Hydrostatic pressure stabilizes HIF‑1α expression in cancer cells to protect against oxidative damage during metastasis

Da Zhai, Yong Xu, Lina Abdelghany, Xu Zhang et autres

The tissue microenvironment is known to play a pivotal role in cancer metastasis. Interstitial fluid hydrostatic pressure generally increases along with the rapid growth of malignant tumors. The aim of the present study was to investigate the role and relevant mechanism of …

jp, cn (code pays fourni par la source)