Donald O. Freytes

A Dynamic Modeling Framework for Real-Time Monitoring of Porcine Lung Tissue Decellularization

Ziyu Wang, Annmarie Bedsaul, Chloe G. Hincher, Maria Jimenez-Socha et autres

Decellularized extracellular matrix (dECM) scaffolds are critical for tissue engineering and regenerative medicine, yet standardized methods for real-time monitoring of decellularization remain lacking. Current protocols typically use fixed treatment durations to match endpoint control quality attributes (CQAs), such as final dsDNA content …

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Nebulized ECM Rescue Device ( NERD ) for Targeted Therapy in Vocal Fold Injuries

Nour Awad, Alexander D. Karabachev, Ramair Colmon, Camilo Mora‐Navarro et autres

OBJECTIVES: Extracellular matrix (ECM)-based scaffolds and gels demonstrate promise for vocal fold scar treatment; however, these injectables necessitate invasive procedures and repeated dosing. Multiple injections to the folds can damage the tissue, leading to fibrotic outcomes. We hypothesize that a nebulized vocal …

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Radiation-Induced Fibrosis in Head and Neck Cancer: Challenges and Future Therapeutic Strategies for Vocal Fold Treatments

Gregory Robert Dion, Maria Jimenez-Socha, Ziyu Wang, Camilo Mora‐Navarro et autres

Head and neck cancer encompasses a diverse group of malignant neoplasms originating in regions such as the oral cavity, oropharynx, hypopharynx, larynx, sinonasal cavities, and salivary glands. HNC represents a significant public health challenge, and recent reports indicate an increment in the …

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Aerosolizable Formulations of Porcine Extracellular Matrix with Antibacterial and Immunomodulatory Effects

Maria Buendia-Otero, Leonel Velez-Roman, Jesus Jimenez-Osorio, Sahimy Ayus-Martinez et autres

Controlling bacterial presence and inflammation in the larynx remains a significant challenge, especially in contexts where infection and immune responses can affect tissue health, prompting growing interest in developing bioactive materials that can be delivered locally and noninvasively to modulate microbial load …

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Nanodiamond‐Infused Microgels for pH‐Tunable Rheology, Lubrication, and UV Protection (Adv. Funct. Mater. 46/2025)

Pallav K. Jani, Sarvesh A. Nadkarni, Katherine J. Ernst, Barbara V. Farias et autres

Nanodiamond-Infused Microgels Skin cancer remains a major health concern. In their Research Article (10.1002/adfm.202504604), Lilian C. Hsiao, Saad A. Khan, and o-workers develop nanodiamond-infused polyacrylic acid microgels that provide broad ultraviolet (UV) radiation protection for topical use to prevent UV-induced skin damage. …

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Nanodiamond‐Infused Microgels for pH‐Tunable Rheology, Lubrication, and UV Protection

Pallav K. Jani, Sarvesh A. Nadkarni, Katherine J. Ernst, Barbara V. Farias et autres

Abstract Ultraviolet (UV) radiation exposure poses a potent threat to human health, with skin cancer cases still prevalent. While skin care formulations mitigate the situation, inherent problematic issues, including toxicity and unpredictable rheology, exist in many of these systems. In this study, …

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Injection of vocal fold lamina propria-derived hydrogels modulates fibrosis in injured vocal folds

Camilo Mora‐Navarro, Ethan D. Smith, Ziyu Wang, Maria Del C Ramos-Alamo et autres

Vocal fold (VF) fibrosis, often resulting from phonosurgery, radiation, or trauma, causes irreversible voice dysfunction due to excessive ECM deposition and increased tissue stiffness. No FDA-approved treatments for VF fibrosis exist, highlighting the need for novel antifibrotic therapies. TGF-β1 contributes to fibroblast-to-myofibroblast …

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Fast Automated Approach for the Derivation of Acellular Extracellular Matrix Scaffolds from Porcine Soft Tissues

Lewis S. Gaffney, Jeffrey R. Enders, Ryan C. Branski, Donald O. Freytes et autres

Decellularized extracellular matrix (ECM) scaffolds derived from tissues and organs are complex biomaterials used in clinical and research applications. A number of decellularization protocols have been described for ECM biomaterials derivation, each adapted to a particular tissue and use, restricting comparisons among …

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Porcine Vocal Fold Lamina Propria-Derived Biomaterials Modulate TGF-β1-Mediated Fibroblast Activation in Vitro

Donald O. Freytes, Erin A. Harrell, Emily W. Ozpinar, Lewis S. Gaffney et autres

The vocal fold lamina propria (VFLP), one of the outermost layers of the vocal fold (VF), is composed of tissue-specific extracellular matrix (ECM) proteins and is highly susceptible to injury. Various biomaterials have been clinically tested to treat voice disorders (e.g., hydrogels, …

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Author response for "Functionalized screen-printed electrodes for non-invasive detection of vascular-endothelial cadherin in extracellular vesicles"

William Meza-Morales, Sahimy Ayus-Martinez, Jesus Jimenez-Osorio, Maria Buendia-Otero et autres

Radiation-Induced Fibrosis in Head and Neck Cancer: Challenges and Future Therapeutic Strategies for Vocal Fold Treatments

Maria Jimenez-Socha, Gregory Robert Dion, Camilo Mora‐Navarro, Ziyu Wang et autres

Head and neck cancer encompasses a diverse group of malignant neoplasms originating in regions such as the oral cavity, oropharynx, hypopharynx, larynx, sinonasal cavities, and salivary glands. HNC represents a significant public health challenge, and recent reports indicate an increment in the …

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From isolation to detection, advancing insights into endothelial matrix-bound vesicles

Luis López, Donald O. Freytes, Camilo Mora‐Navarro, Maria Buendia-Otero et autres

Matrix-bound vesicles (MBVs), an integral part of the extracellular matrix (ECM), are emerging as pivotal factors in ECM-driven molecular signaling. This study is the first to report the isolation of MBVs from porcine arterial endothelial cell basement membranes (A-MBVs) and thyroid cartilage …

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