Zhibin Lin

Metabolic stress-activated endothelial STING rewires the sinusoidal immune niche in MASLD

Zhibin Lin, Peng Zou, Xian-Yi Ma, Jun-Bo Song et autres

Liver sinusoidal endothelial cells (LSECs) regulate nutrient flux and immune surveillance within the hepatic niche, yet how they function as metabolic stress sensors that instruct adaptive immune remodeling during metabolic dysfunction-associated steatotic liver disease (MASLD) remains unclear. Here, single-nucleus transcriptomics of human …

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Sanqi Oral Solution Containing Serum Ameliorates C5b-9 Induced Podocyte Injury via the Endoplasmic Reticulum Stress/Unfolded Protein Response Dependent Pathway

Yi Du, Zhibin Lin, Zhenyu Wu

Sanqi oral solution (SQ), a traditional Chinese medicine that is mainly composed of Astragalus membranaceus and Panax notoginseng, has been widely used for alleviating idiopathic membranous nephropathy, but its underlying molecular mechanism remains unclear. This study aims to investigate the effects of …

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Immune cell landscape in a human decedent receiving a pig liver xenograft

Kaishan Tao, Xuan Zhang, Zhao-Xu Yang, Hongtao Zhang et autres

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Gene-modified pig-to-human liver xenotransplantation

Kaishan Tao, Zhao-Xu Yang, Xuan Zhang, Hongtao Zhang et autres

The shortage of donors is a major challenge for transplantation; however, organs from genetically modified pigs can serve as ideal supplements1,2. Until now, porcine hearts and kidneys have been successively transplanted into humans3–7. In this study, heterotopic auxiliary transplantation was used to …

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Correction: Translationally controlled tumor protein promotes liver regeneration by activating mTORC2/AKT signaling

Zhibin Lin, Xuan Zhang, Jianlin Wang, Wei Liu et autres

The original version of this article contains a mistake in Fig. 6f. When integrating the figures, one field of the “2d TCTP +/- ” liver section in Fig. 2c was wrongly selected for the “TCTP +/- +IGF-1” group in Fig. 6f, since …

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Association between Methylmalonic Acid and Abdominal Aortic Calcification in Adults: A Cross-Sectional Study

Jun Chen, Yingwen Lin, Zhonghua Teng, Zhibin Lin et autres

Objective: Methylmalonic acid (MMA) buildup has recently been suggested to contribute to the onset of both age-related conditions and cardiovascular disorders. This research was aimed at examining the link between MMA and abdominal aortic calcification (AAC). Methods: Data from the 2013–2014 National …

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The deubiquitinating enzyme USP19 facilitates hepatocellular carcinoma progression through stabilizing YAP

Zelin Tian, Chen Xu, Weixiang He, Zhibin Lin et autres

Hippo pathway plays a crucial role in the progression of hepatocellular carcinoma (HCC), and yes-associated protein (YAP) is one of the major factors of the Hippo pathway. However, the mechanism of abnormal YAP activation in HCC has not been well elucidated. Here, …

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Molecular pathogenesis: Connections between viral hepatitis-induced and non-alcoholic steatohepatitis-induced hepatocellular carcinoma

Zelin Tian, Xu Chen, Peijun Yang, Zhibin Lin et autres

Hepatocellular carcinoma(HCC) is the sixth most common cancer in the world and is usually caused by viral hepatitis (HBV and HCV), alcoholic, and non-alcoholic fatty liver disease(NAFLD). Viral hepatitis accounts for 80% of HCC cases worldwide. In addition, With the increasing incidence …

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Tripartite motif 16 ameliorates nonalcoholic steatohepatitis by promoting the degradation of phospho-TAK1

Lin Wang, Xin Zhang, Zhibin Lin, Peijun Yang et autres

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The mRNA of TCTP functions as a sponge to maintain homeostasis of TCTP protein levels in hepatocellular carcinoma

Wei Liu, Qi Liu, Beilei Zhang, Zhibin Lin et autres

Translationally controlled tumor protein (TCTP) is a highly conserved protein that accumulated in the tumorigenesis of various malignancies. Despite the important role of TCTP protein in tumor progression, the precise function and underlying mechanistic regulation of TCTP mRNA in hepatocellular carcinoma (HCC) …

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The resurgent landscape of xenotransplantation of pig organs in nonhuman primates

Xuan Zhang, Quancheng Wang, Jingjun Zhao, Xiao Li et autres

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LINC00671 suppresses cell proliferation and metastasis in pancreatic cancer by inhibiting AKT and ERK signaling pathway

Shibin Qu, Kunwei Niu, Jianlin Wang, Jimin Dai et autres

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