Kun‐Che Chang

Retinal ganglion cell-derived vesicles: A new path to neuroprotection

Kun‐Che Chang

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Aldose reductase as a regulator of ocular pathology: Mechanisms and therapeutic potential.

Laman Mirzaliyeva, Pei‐Kang Liu, Dimitrios Stavropoulos, Kun‐Che Chang

Aldose reductase (AR), the rate-limiting enzyme of the polyol pathway, converts glucose to sorbitol using NADPH and becomes markedly overactive under hyperglycemic conditions. Its widespread expression in ocular tissues links AR to numerous eye disorders through sorbitol accumulation, microglial activation, NADPH depletion, …

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Carboplatin induces optic nerve oligodendrocyte loss and impairs myelin sheath microstructure in a mouse model of neurofibromatosis type 1

Benjamin E. Aghoghovwia, Kechen Ban, Dimitrios Stavropoulos, Chi‐Yu Chen et autres

BACKGROUND: Vision impairment is a significant concern for children with Neurofibromatosis type 1 (NF1)-associated optic pathway glioma (OPG). While carboplatin-containing chemotherapy is often first-line therapy for NF1-OPG, it does not consistently improve visual function. Furthermore, chemotherapy is associated with altered white matter …

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Assessing the therapeutic effects of DPP4 Inhibitors on TGF-β2-induced Lens Opacity

Niki Talebian, P. P. Liu, Joanne Lee, Ya-Ling Lin et autres

Posterior capsular opacification (PCO) is a common complication following cataract surgery, resulting from the epithelial-mesenchymal transition (EMT) of lens epithelial cells (LECs). PCO continues to represent a significant public health challenge due to its detrimental impact on visual outcomes, with many patients …

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Enzymatic Disruption of the Internal Limiting Membrane Enhances Transplanted Retinal Ganglion Cell Survival

Dimitrios Stavropoulos, Chia-Chun Liu, Chi‐Yu Chen, Laman Mirzaliyeva et autres

Purpose: In mammals, retinal ganglion cells (RGCs) lack the ability to regenerate after injury, and RGC transplantation is a potential approach for cell replacement therapy. However, the internal limiting membrane (ILM) in the retina serves as a significant barrier to donor cell …

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Quercetin attenuates high glucose-induced VEGFA expression in ARPE-19 cells by inhibiting ROS generation, p38 MAPK phosphorylation, and NF-κB activation

Pei‐Kang Liu, Yi‐Chun Chi, Yo-Chen Chang, Yi-Hsiung Lin et autres

Hyperglycemia-driven oxidative stress and inflammatory signaling in retinal pigment epithelium (RPE) promote overexpression of vascular endothelial growth factor A (VEGFA), contributing to the pathogenesis of diabetic retinopathy (DR). Quercetin, a dietary flavonoid with antioxidant and anti-inflammatory properties, has not been fully evaluated …

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CNSC-14. CARBOPLATIN IMPAIRS OPTIC NERVE MYELINATION IN NEUROFIBROMATOSIS TYPE 1 (NF1) BY REDUCING CHOLESTEROL LEVELS AND INDUCING OLIGODENDROCYTE LOSS

Benjamin E. Aghoghovwia, Helmy Eltoukhy, Ava Hamblett, Varsha Chandramouli et autres

Abstract BACKGROUND Vision impairment is a major concern for patients with Neurofibromatosis type 1 (NF1)-associated optic pathway glioma (OPG). Carboplatin-based chemotherapy is commonly used to treat NF1-OPG, but it does not consistently improve optic pathway neuron function. Chemotherapy is associated with changes …

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The distinct roles of TGF-β signaling in retinal development

Chi‐Yu Chen, Chia-Chun Liu, Dimitrios Stavropoulos, Pei‐Kang Liu et autres

knockout increased RGCs but reduced photoreceptors, indicating a broader influence on retinal cell fate. Transcriptomic analysis revealed altered RGC subtype markers and genes involved in axon formation and guidance. These findings highlight a GDF-TGFβ regulatory network in RGC specification and provide insights …

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Insights from TPPP3 and its family member proteins in neuronal diseases

Mishal Rao, Kun‐Che Chang

Tubulin polymerization-promoting protein family member 3 (TPPP3) is a neuronal-specific protein involved in cytoskeletal stability, axonal maintenance, and neuronal survival. Dysregulation of TPPP3 is implicated in neurodegenerative diseases such as Parkinson's disease and diabetic retinopathy. Unlike TPPP1, which is oligodendrocyte-specific, TPPP3 was …

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3D-printed plugs enhance cell usage efficiency for single-cell migration and neuron axon guidance assays

Jinxiong Cheng, Edwin C. Rock, Mishal Rao, Hsiao-Chun Chen et autres

This paper reports a 3D-printed plug as a meso-scale interface solution that minimizes sample loss and enhances cell usage efficiency, seamlessly connecting microfluidic systems to conventional well plates. The plug concentrates cells near the region of interest for chemotaxis, reducing cell number …

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Sodium silicate complex reduces subdermal hemorrhage and prolongs survival after envenomation by Trimeresurus stejnegeri stejnegeri

Yen-Chia Chen, Hao‐Ming Chang, Chang-Chih Ke, Chia-Chun Liu et autres

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Anti-cancer effects of Psoralea corylifolia: insights into cancer hallmarks

Pin-Rong Chen, Ta‐Chen Su, Kun‐Che Chang, Chien‐Chih Chiu et autres

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