Miriam Hattle

MODERATORS OF THE EFFECT OF THERAPEUTIC EXERCISE FOR KNEE AND/OR HIP OSTEOARTHRITIS: A SYSTEMATIC REVIEW AND INDIVIDUAL PARTICIPANT DATA META-ANALYSIS

Amardeep Legha, Danielle Burke, Daniëlle van der Windt, Emma Healey et autres

M. Holden1, M. Hattle1, J. Runhaar2, R. Riley1, E. Healey1, J. Quicke3,1, D. van der Windt4, K. Dziedzic4, M. van Middelkoop2, D. Burke1, N. Corp1, A. Legha1, S. Bierma-Zeinstra2, N.E. Foster5,6,1, O.A. Trial Bank Exercise Collaborative71Keele University, School of Medicine, Primary Care …

RELATIVE EFFECTIVENESS OF DIFFERENT TYPES OF THERAPEUTIC EXERCISE FOR PEOPLE WITH KNEE AND/OR HIP OSTEOARTHRITIS: A SYSTEMATIC REVIEW UPDATE AND INDIVIDUAL PARTICIPANT DATA NETWORK META-ANALYSIS.

Philippa J. Nicolson, Ram Bajpai, Miriam Hattle, Marienke v. Middelkoop et autres

gb, nl, au (code pays fourni par la source)

State of play in individual participant data meta-analyses of randomised trials: Systematic review and consensus-based recommendations

Anna Lene Seidler, Jannik Aagerup, Lily Nicholson, Kylie E Hunter et autres

Abstract Background Individual participant data (IPD) meta-analyses obtain, harmonise and synthesise the raw individual-level data from multiple studies, and are increasingly important in an era of data sharing and personalised medicine to inform clinical practice and policy. Objectives (1) Describe the landscape …

au, gb, de, sg, no, ch, hu, us (code pays fourni par la source)

Development and evaluation of the electronic frailty index+ (eFI+) tool for older people: prognostic prediction modelling with integrated decision curve and health economic analysis

Lucinda Archer, Samuel David Relton, Ashley Akbari, Kate Best et autres

Background: Our aim was to develop and evaluate the electronic frailty index+, a prognostic tool, including four integrated prognostic-decision models, to stratify older people into subgroups for targeting key interventions. Methods: Prognostic model development, internal validation and external validation using large data …

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Individual participant data meta‐analysis to examine linear or non‐linear treatment‐covariate interactions at multiple time‐points for a continuous outcome

Miriam Hattle, Joie Ensor, Katie Scandrett, Marienke van Middelkoop et autres

Individual participant data (IPD) meta-analysis projects obtain, harmonise, and synthesise original data from multiple studies. Many IPD meta-analyses of randomised trials are initiated to identify treatment effect modifiers at the individual level, thus requiring statistical modelling of interactions between treatment effect and …

gb, nl (code pays fourni par la source)

Development and initial evaluation of a clinical prediction model for risk of treatment resistance in first-episode psychosis: Schizophrenia Prediction of Resistance to Treatment (SPIRIT)

Saeed Farooq, Miriam Hattle, Tom Kingstone, Olesya Ajnakina et autres

BACKGROUND: A clinical tool to estimate the risk of treatment-resistant schizophrenia (TRS) in people with first-episode psychosis (FEP) would inform early detection of TRS and overcome the delay of up to 5 years in starting TRS medication. AIMS: To develop and evaluate …

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Calculating the power of a planned individual participant data meta‐analysis to examine prognostic factor effects for a binary outcome

Rebecca Whittle, Joie Ensor, Miriam Hattle, Paula Dhiman et autres

Collecting data for an individual participant data meta-analysis (IPDMA) project can be time consuming and resource intensive and could still have insufficient power to answer the question of interest. Therefore, researchers should consider the power of their planned IPDMA before collecting IPD. …

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People with short symptom duration of knee osteoarthritis benefit more from exercise therapy than people with longer symptom duration: An individual participant data meta-analysis from the OA trial bank

Marienke van Middelkoop, Dieuwke Schiphof, Miriam Hattle, Jacques Simkins et autres

OBJECTIVE: To investigate whether duration of knee symptoms influenced the magnitude of the effect of exercise therapy compared to non-exercise control interventions on pain and physical function in people with knee osteoarthritis (OA). METHOD: We undertook an individual participant data (IPD) meta-analysis …

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NEITHER ANALYSIS APPROACH NOR RISK OF BIAS EXPLAIN THE LIMITED OVERALL BENEFIT OF THERAPEUTIC EXERCISE FOR KNEE AND/OR HIP OSTEOARTHRITIS IN INDIVIDUAL PARTICIPANT DATA META-ANALYSIS

J. Runhaar, Melanie Ann Holden, Miriam Hattle, Jonathan George Quicke et autres

nl, gb, au (code pays fourni par la source)

MODERATORS OF MECHANICAL DEVICE EFFICACY IN KNEE OSTEOARTHRITIS: AN OA TRIAL BANK INDIVIDUAL PARTICIPANT DATA ANALYSIS

Erin M. Macri, Michael James Callaghan, Marienke van Middelkoop, Miriam Hattle et autres

nl, gb, dk, au, br, fr, us, ca, in, lt, ch (code pays fourni par la source)

Development and external validation of the eFalls tool: a multivariable prediction model for the risk of ED attendance or hospitalisation with a fall or fracture in older adults

Lucinda Archer, Samuel David Relton, Ashley Akbari, Kate Best et autres

BACKGROUND: Falls are common in older adults and can devastate personal independence through injury such as fracture and fear of future falls. Methods to identify people for falls prevention interventions are currently limited, with high risks of bias in published prediction models. …

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Risk of bias assessments in individual participant data meta-analyses of test accuracy and prediction models: a review shows improvements are needed

Brooke Levis, Kym I E Snell, Johanna AAG Damen, Miriam Hattle et autres

OBJECTIVES: Risk of bias assessments are important in meta-analyses of both aggregate and individual participant data (IPD). There is limited evidence on whether and how risk of bias of included studies or datasets in IPD meta-analyses (IPDMAs) is assessed. We review how …

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