Irina A. Ishina

Mapping organ-associated autoantigenic landscapes in systemic lupus erythematosus

Ekaterina O. Sosedskaia, Irina A. Ishina, T Reshetnyak, Evgeniy L'vovich Nasonov et autres

Systemic lupus erythematosus (SLE) is a systemic autoimmune disease characterized by a remarkably broad and heterogeneous autoantigen repertoire. While epitope spreading, aberrant B-cell activation, and molecular mimicry act in concert with defective apoptotic clearance and sustained type I interferon signaling to drive …

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Autoantigenic peptide landscape of rheumatoid arthritis-associated HLA class II

Irina A. Ishina, Anton Zhiyanov, Inna N. Kurbatskaia, Azad E. Mamedov et autres

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Antigenic peptide–thioredoxin fusion chimeras for in vitro stimulus of CD4+ TCR+ Jurkat T-cells

Irina A. Ishina, Maria Yu. Zakharova, Inna N. Kurbatskaia, A. E. Mamedov et autres

Study of CD4+ T-cell response and T-cell receptor (TCR) specificity is crucial for understanding etiology of immune-mediated diseases and developing targeted therapies. However, solubility, accessibility, and stability of synthetic antigenic peptides used in T-cell assays may be a critical point in such …

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Antigenic Peptide-Thioredoxin Fusion Chimeras for In Vitro Stimulus of CD4+ TCR+ Jurkat T Cells

Irina A. Ishina, Maria Yu. Zakharova, Inna N. Kurbatskaia, A. E. Mamedov et autres

Abstract Study of CD4+ T cell response and T cell receptor (TCR) specificity is crucial for understanding etiology of immune-mediated diseases and developing targeted therapies. However, solubility, accessibility, and stability of synthetic antigenic peptides used in T cell assays may be a …

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Genetically engineered CD80–pMHC-harboring extracellular vesicles for antigen-specific CD4+ T-cell engagement

Irina A. Ishina, Inna N. Kurbatskaia, Azad E. Mamedov, Elena I. Shramova et autres

The identification of low-frequency antigen-specific CD4+ T cells is crucial for effective immunomonitoring across various diseases. However, this task still encounters experimental challenges necessitating the implementation of enrichment procedures. While existing antigen-specific expansion technologies predominantly concentrate on the enrichment of CD8+ T …

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MHC Class II Presentation in Autoimmunity

Irina A. Ishina, Maria Yu. Zakharova, Inna N. Kurbatskaia, Azad E. Mamedov et autres

T cells and maintaining self-antigen tolerance. Some MHC-II alleles are known to be positively or negatively associated with the risk of the development of different autoimmune diseases (ADs), including those characterized by the emergence of autoreactive T cells. Apparently, the MHC-II presentation …

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Alterations in SARS-CoV-2 Omicron and Delta peptides presentation by HLA molecules

Stepan A. Nersisyan, Anton Zhiyanov, Maria V. Zakharova, Irina A. Ishina et autres

The T-cell immune response is a major determinant of effective SARS-CoV-2 clearance. Here, using the recently developed T-CoV bioinformatics pipeline (https://t-cov.hse.ru) we analyzed the peculiarities of the viral peptide presentation for the Omicron, Delta and Wuhan variants of SARS-CoV-2. First, we showed …

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Alterations in SARS-CoV-2 Omicron and Delta peptides presentation by HLA molecules

Stepan A. Nersisyan, Anton Zhiyanov, Maria V. Zakharova, Irina A. Ishina et autres

Abstract The T-cell immune response is a major determinant of effective SARS-CoV-2 clearance. Here, using the recently developed T-CoV bioinformatics pipeline ( https://t-cov.hse.ru ) we analyzed the peculiarities of the viral peptide presentation for the Omicron, Delta and Wuhan variants of SARS-CoV-2. …

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NETO2 Is Deregulated in Breast, Prostate, and Colorectal Cancer and Participates in Cellular Signaling

Maria Fedorova, Anastasiya V. Snezhkina, Anastasiya V. Lipatova, Vladislav Pavlov et autres

The NETO2 gene (neuropilin and tolloid-like 2) encodes a protein that acts as an accessory subunit of kainate receptors and is predominantly expressed in the brain. Upregulation of NETO2 has been observed in several tumors; however, its role in tumorigenesis remains unclear. …

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Exhaustive Search of the Receptor Ligands by the CyCLOPS (Cytometry Cell-Labeling Operable Phage Screening) Technique

Irina A. Ishina, Ioanna N. Filimonova, Maria Yu. Zakharova, Leyla A. Ovchinnikova et autres

Effective and versatile screening of the peptide ligands capable of selectively binding to diverse receptors is in high demand for the state-of-the-art technologies in life sciences, including probing of specificity of the cell surface receptors and drug development. Complex microenvironment and structure …

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The CIMP-high phenotype is associated with energy metabolism alterations in colon adenocarcinoma

Maria Fedorova, George Sergeevich Krasnov, Elena Lukyanova, Andrew R. Zaretsky et autres

BACKGROUND: CpG island methylator phenotype (CIMP) is found in 15-20% of malignant colorectal tumors and is characterized by strong CpG hypermethylation over the genome. The molecular mechanisms of this phenomenon are not still fully understood. The development of CIMP is followed by …

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Additional file 2: of The CIMP-high phenotype is associated with energy metabolism alterations in colon adenocarcinoma

Maria Fedorova, George Sergeevich Krasnov, Elena Lukyanova, Andrew R. Zaretsky et autres

Table S1. Differential expression profiles of â Glycolysis/Gluconeogenesisâ KEGG pathway genes in colon adenocarcinomas compared to normal tissues (TCGA data). The color scale indicates the degree of change. (XLSX 836 kb)