Sabrina Racine‐Brzostek

Comparative evaluation of five tacrolimus assays in transplant recipients: implications for optimizing therapeutic drug monitoring

Ivo N. SahBandar, Zhen Zhao, Sabrina Racine‐Brzostek, Maria Cinta Cid et autres

Tacrolimus is a widely used immunosuppressive therapy in transplant recipients, but its narrow therapeutic index necessitates accurate monitoring. Tacrolimus levels can be quantified using immunoassays (IAs) and liquid chromatography-tandem mass spectrometry (LC-MS/MS), however, differences between these methods may influence clinical decision-making. In …

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Retrospective Evaluation of the Diagnostic Performance and Safety of a Reflex Urine Culture Algorithm in Pediatrics

Karen P. Acker, Xiaoyue Ma, Hannah J. Joyce, W. G. Shin et autres

BACKGROUND: Obtaining urine cultures (UCx) in the absence of symptoms and inflammation can result in misdiagnosis of urinary tract infections (UTIs) and inappropriate use of antibiotics. Reflex UCx is a diagnostic stewardship strategy in which a UCx is performed only if a …

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B-147 Evaluation of the specialized Medicine-GPT for adolescent health inquiries related to diagnostics and laboratory tests

Sabrina Racine‐Brzostek, He S. Yang

Abstract Background Large language models (LLMs) are generative AI systems designed to simulate human-like conversation. Recently, LLMs have advanced in understanding questions, retrieving accurate answers, and performing sophisticated reasoning—capabilities that improve access to medical information. In particular, specialized medical LLMs have been …

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Abstract B131: Association between type 2 diabetes and prevalence of monoclonal gammopathy of undetermined significance in a large screened U.S. population

Etienne X. Holder, Mallory P. Bernstein, Jia Y. Wan, Esther Lam et autres

Abstract Introduction: Monoclonal gammopathy of undetermined significance (MGUS) is a benign clone of plasma cells and a necessary precursor to multiple myeloma (MM) — a rare and fatal cancer of the blood that is 2-3 times more common in Black men and …

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Transiently acquired hemoglobin variants in patients with sickle cell disease: A case series and systematic review of the literature

Maha Al‐Ghafry, Abraham Haimed, Tamara N. New, Carrie Gann et autres

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Sankey diagrams: A simple, intuitive way to visualize and analyze complex, convoluted transfusion medicine operations data

Dennis Chen, Priscilla Parra, Denden Benabdessadek, Pooja S. Desai et autres

2026-06-09

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Preanalytical Considerations of Handling Suspected Creutzfeldt–Jakob Disease Specimens Within the Clinical Pathology Laboratories: A Survey-Based Approach

Carla Stephan, Taylor A. Kalomeris, Yaxin Li, Jeffrey M. Kubiak et autres

Background: Creutzfeldt–Jakob disease (CJD) is a rare, fatal, and transmissible neurodegenerative disorder caused by prion proteins. Handling specimens from individuals with suspected or confirmed cases presents a safety challenge to hospital workers including clinical laboratory staff. As no national guidelines exist, the …

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Acquired Prothrombotic Conditions

Sabrina Racine‐Brzostek, Morayma Reyes Gil

List of Contributors

Rim Abdallah, Suchitra S. Acharya, Joel Addams, Ahmad H. Al-Huniti et autres

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Comparison of five tacrolimus measurement methods underscore the need for a standardized method to improve clinical outcomes

Ivo Sah Bandar, He S. Yang, Alex Rai, Sabrina Racine‐Brzostek et autres

Abstract Tacrolimus is a widely used drug to prevent post-transplantation organ rejection by suppressing host immune response. While its efficacy is well established, tacrolimus is also known for narrow therapeutic index and debilitating adverse effects, rendering accurate measurement for therapeutic drug monitoring …

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Thirty years of experience with solvent/detergent‐treated plasma for transfusion medicine

Sabrina Racine‐Brzostek, Melissa M. Cushing, Michelle Gareis, Andrea Heger et autres

Fresh frozen plasma (FFP) is one of the most commonly prescribed hemostatic agents in clinical practice globally.1 Main FFP indications include acquired deficiency of multiple coagulation factors during active bleeding, bleeding prevention, and therapeutic plasma exchange (TPE).2, 3 Patients with thrombotic thrombocytopenic …

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Epigenetic memory of coronavirus infection in innate immune cells and their progenitors

Jin‐Gyu Cheong, Arjun Ravishankar, Siddhartha Sharma, Christopher N. Parkhurst et autres

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