Cleber Furtado Aksenen

Enhancing SARS-CoV-2 Lineage Surveillance through the Integration of a Simple and Direct qPCR-Based Protocol Adaptation with Established Machine Learning Algorithms

Cleber Furtado Aksenen, DANIELE VIEIRA FERREIRA, Pedro Miguel Carneiro Jerônimo, Thaís De Oliveira Costa et autres

High Resolution Image Download MS PowerPoint Slide Emerging and evolving Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) lineages, adapted to changing epidemiological conditions, present unprecedented challenges to global public health systems. Here, we introduce an adapted analytical approach that complements genomic sequencing, …

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Enhancing SARS-CoV-2 Lineage surveillance through the integration of a simple and direct qPCR-based protocol adaptation with established machine learning algorithms

Cleber Furtado Aksenen, DANIELE VIEIRA FERREIRA, Pedro Miguel Carneiro Jerônimo, Thaís De Oliveira Costa et autres

ABSTRACT The emergence of the SARS-CoV-2 and continuous spread of its descendent lineages have posed unprecedented challenges to the global public healthcare system. Here we present an inclusive approach integrating genomic sequencing and qPCR-based protocols to increment monitoring of variant Omicron sublineages. …

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ViralFlow v1.0—a computational workflow for streamlining viral genomic surveillance

Alexandre Freitas da Silva, Antônio Marinho da Silva Neto, Cleber Furtado Aksenen, Pedro Miguel Carneiro Jerônimo et autres

ViralFlow v1.0 is a computational workflow developed for viral genomic surveillance. Several key changes turned ViralFlow into a general-purpose reference-based genome assembler for all viruses with an available reference genome. New virus-agnostic modules were implemented to further study nucleotide and amino acid …

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Serological and epidemiological investigation of predictive factors associated with the humoral response profile of COVID-19 in blood donors from Fortaleza

Cleber Furtado Aksenen

The evolution of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has led to the emergence of increasingly adapted variants to the epidemiological landscape, in addition to fluctuations in the number of cases and deaths from the disease (COVID19) during critical moments of …

Evolutionary deletions within the SARS-CoV-2 genome as signature trends for virus fitness and adaptation

Pedro Miguel Carneiro Jerônimo, Cleber Furtado Aksenen, Igor Oliveira Duarte, Roberto Dias Lins et autres

Coronaviruses are large RNA viruses that can infect and spread among humans and animals. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), responsible for coronavirus disease 2019, has evolved since its first detection in December 2019. Deletions are a common occurrence in SARS-CoV-2 …

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ViralFlow: A Versatile Automated Workflow for SARS-CoV-2 Genome Assembly, Lineage Assignment, Mutations and Intrahost Variant Detection

Filipe Zimmer Dezordi, Antônio Marinho da Silva Neto, Túlio de Lima Campos, Pedro Miguel Carneiro Jerônimo et autres

The COVID-19 pandemic is driven by Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2) that emerged in 2019 and quickly spread worldwide. Genomic surveillance has become the gold standard methodology used to monitor and study this fast-spreading virus and its constantly emerging lineages. …

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ViralFlow: an automated workflow for SARS-CoV-2 genome assembly, lineage assignment, mutations and intrahost variants detection

Filipe Zimmer Dezordi, Túlio de Lima Campos, Pedro Miguel Carneiro Jerônimo, Cleber Furtado Aksenen et autres

ABSTRACT The COVID-19 pandemic, a disease caused by the Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2), emerged in 2019 and quickly spread worldwide. Genomic surveillance has become the gold standard methodology to monitor and study this emerging virus. The current deluge of …

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