Saime Batırel

0053Fatty Acid Remodeling Links the Atherogenic Index of Plasma to Coronary Artery Disease Severity

Saime Batırel, Bengu Cetinkaya, T. Guctekin, Beste Özben et autres

Background The relative contributions of the atherogenic index of plasma (AIP) and triglyceride–glucose (TyG) index to coronary artery disease (CAD) severity remain unclear, and their links with fatty acid metabolism have not been systematically investigated. Methods Sixty-one patients undergoing coronary angiography were …

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Atherogenic Index of Plasma in Relation to Angiographic Coronary Artery Disease Severity, Plasma Fatty Acid Composition, and Estimated Desaturase Activity: A Cross-Sectional Study

Saime Batırel, Büşra Çetinkaya, Ali Şahin, T. Guctekin et autres

Background/Objectives: Conventional lipid parameters incompletely reflect coronary atherosclerotic burden, particularly in the setting of metabolic heterogeneity and residual cardiovascular risk. Composite indices such as the atherogenic index of plasma (AIP) and the triglyceride–glucose (TyG) index have emerged as integrative markers. Fatty acid …

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Temperature-triggered structural arrangement and properties of transparent pectin-arginine films

Anıl Yılmaz, Ö. Zeynep Güner-Yılmaz, Banu Kocaağa, Gülşah Torkay-Çay et autres

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Exploratory Analysis of Circulating GLP-1, GIP, and TMAO in Relation to Coronary Artery Disease Severity in Patients with Exertional Angina

Saime Batırel, Bengü Çetinkaya, Ali Sahin, Nodira Alakbarova et autres

Background/Objectives: The gut–heart axis has garnered increasing attention. Incretin hormones such as glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP), along with trimethylamine N-oxide (TMAO), have been implicated in the pathogenesis of coronary artery disease (CAD). This study aimed to investigate associations …

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Resveratrol Triggers p53-Independent Mitochondrial Apoptosis in Castration-Resistant Prostate Cancer Cells

Ayşe Mine Yılmaz, Bengü Çetinkaya, Saime Batırel

Objective: Resveratrol is a pleiotropic phytochemical with reported anticancer activity, yet its mechanism in castration-resistant prostate cancer (CRPC) remains uncertain. We investigated whether resveratrol triggers a p53-independent, reactive oxygen species (ROS)-driven, mitochondria-initiated apoptotic program in DU145 cells. Methods: DU145 human prostate cancer …

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Graphene oxide-based and porous nanocarriers for drug delivery developed with computational and experimental approaches

Zeynep Güner-Yılmaz, Banu Kocaağa, Anıl Yılmaz, Marcel Balçık et autres

Graphene oxide-based and porous nanocarriers for drug delivery developed with computational and experimental approaches

Ö. Zeynep Güner-Yılmaz, Banu Kocaağa, Anıl Yılmaz, Marcel Balçık et autres

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The Inhibitory Effects of Resveratrol on Tumor Growth and Metastasis in Esophageal Adenocarcinoma

Saime Batırel, Büşra Çetinkaya, Ayşe Mine Yılmaz

Objective: Resveratrol is a small polyphenol that has been extensively researched across various therapeutic areas. Its inhibitory effect on esophageal cancer cell growth has also been demonstrated in a dose- and time-dependent manner. However, the underlying mechanism of this effect has not …

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Fabrication of Multifunctional Nanofiber Mats by Emulsion Electrospinning of TPU/Fish Skin Gelatin Incorporating Plant Extract‐Based Therapeutic Oil for Wound Dressing Applications

Rüya Keskinkaya, Arzu Yıldırım, Şeyma Çağlayan, Eray Sarper Erdoğan et autres

Abstract In this study, for the first time thermoplastic polyurethane (TPU), fish skin gelatin (FSG), and H. perforatum oil (HPO) combine to form a new nanofiber material by using the emulsion electrospinning technique. Scanning electron microscope (SEM), Fourier transform infrared (FTIR) spectroscopy, …

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Influence of Synthesis Temperature on Structural Arrangement and Properties of Transparent Pectin-Arginine Films

Fatma Seniha Güner, Anıl Yılmaz, Zeynep Yilmaz-Guner, Banu Kocaağa et autres

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Fabrication of MIL-101(Fe)-embedded biopolymeric films and their biomedical applications

Banu Kocaağa, Gamze Bagimsiz, Ibrahim Avni Alev, Mehran Aliari Miavaghi et autres

Abstract The development of wound-dressing materials with superior therapeutic effects, controlled bioactive agent release, and optimal mechanical properties is crucial in healthcare. This study introduces innovative hydrogel films designed for the sustained release of the local anesthetic drug Procaine (PC), triggered by …

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Developing multifunctional pectin-based hydrogel for wound dressing: In silico, in vitro and in vivo evaluation

Banu Kocaağa, Yetkin Öztürk, H. Ceren Kurçin, Ö. Zeynep Güner‐Yılmaz et autres

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