Timothy L. Smith

Efficacy and Predictors of Response to Biologic Therapy and Endoscopic Sinus Surgery in Patients With Nasal Polyps: A Systematic Review

Arun K. Chakravorty, Matthew E. Lin, Rory Lubner, Jess C. Mace et autres

BACKGROUND: Biologics and endoscopic sinus surgery (ESS) treat refractory chronic rhinosinusitis with nasal polyposis (CRSwNP), but direct comparisons are lacking. We synthesized efficacy and subgroup data across randomized controlled trials (RCTs) of biologics and ESS. METHODS: PubMed was searched through December 2025 …

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Impact of Medical Treatment on Nasal Discharge in Chronic Rhinosinusitis: A Systematic Review and Meta-Analysis

Asher T. Ripp, Ethan M. Kallenberger, Erin E. Briggs, Alexander Duffy et autres

Background One of the defining symptoms of chronic rhinosinusitis is nasal discharge. There are multiple treatment options, and the relative efficacy of each medication on discharge is unclear. Objective To characterize the effects of medical treatment on the various forms of nasal …

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Olfaction, Eating Preference, and Quality of Life in Cystic Fibrosis Chronic Rhinosinusitis

Cameran Owens, Todd Bodner, Naweed I. Chowdhury, Jeremiah A. Alt et autres

OBJECTIVES: Olfactory dysfunction (OD) is common among people with cystic fibrosis (PwCF) and chronic rhinosinusitis (CRS). OD is associated with impaired quality of life (QOL) and dietary alterations in certain non-CF populations. This study explored relationships between OD, QOL, and modulator use …

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Preoperative Pollen Exposure and Chronic Rhinosinusitis Outcomes After Endoscopic Sinus Surgery: A Pilot Investigation

Benton Tullis, Jess C. Mace, Conner Massey, Stuart Batterman et autres

ABSTRACT Background Although particulate matter is an environmental factor that may increase the risk of developing chronic rhinosinusitis (CRS), the impact of pollen on CRS outcomes is understudied. Here, we analyzed the effects of preoperative pollen exposure on disease‐specific and general quality‐of‐life …

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Determining the Minimal Clinically Important Difference of the 40‐Item Smell Identification Test in People With Cystic Fibrosis

Eugene Oh, Jessa E. Miller, Michelle J. Lee, Anna C. Zemke et autres

BACKGROUND: Chronic rhinosinusitis (CRS) and olfactory dysfunction (OD) are highly prevalent among people with cystic fibrosis (PwCF) and negatively impact quality of life. The 40-item Smell Identification Test (SIT) is widely used to assess psychophysical olfaction, but a CF-specific minimal clinically important …

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Recurrence is Not Associated with a Reduced Quality of Life in Patients with Recurrent Sinonasal Malignancy

Jason R. Crossley, Abigail R. Cartus, Daniel M. Beswick, P H Hwang et autres

Introduction: Sinonasal cancer represents a heterogenous group of malignancies which as a group have poor survival. Recent work demonstrates that patients with sinonasal malignancy have lower quality of life prior to treatment (QoL). Patients with other solid tumors have been found to …

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Machine Learning Based Prediction of Surgical Outcomes in Chronic Rhinosinusitis from Clinical Data

Sayeed Shafayet Chowdhury, Karen D Souza, V. Siva Kakumani, Snehasis Mukhopadhyay et autres

Artificial intelligence (AI) has increasingly transformed medical prognostics by enabling rapid and accurate analysis across imaging and pathology. However, the investigation of machine learning predictions applied to prospectively collected, standardized data from observational clinical intervention trials remains underexplored, despite its potential to …

Machine Learning Based Prediction of Surgical Outcomes in Chronic Rhinosinusitis from Clinical Data

Sayeed Shafayet Chowdhury, Karen D Souza, V. Siva Kakumani, Snehasis Mukhopadhyay et autres

Artificial intelligence (AI) has increasingly transformed medical prognostics by enabling rapid and accurate analysis across imaging and pathology. However, the investigation of machine learning predictions applied to prospectively collected, standardized data from observational clinical intervention trials remains underexplored, despite its potential to …

The nature of nasal discharge in chronic rhinosinusitis: a systematic review and meta-analysis using patient-reported outcomes

Ethan M. Kallenberger, Asher T. Ripp, Shaun A. Nguyen, Erin E. Briggs et autres

Objective: The objective of this study is to answer the question "What is the most common and severe type of nasal discharge in patients with chronic rhinosinusitis (CRS) at baseline as measured by patient-reported outcomes?". Methodology: Two independent reviewers evaluated studies for …

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Pollen Exposure and Chronic Rhinosinusitis Quality of Life Disease Severity

Benton Tullis, Jess C. Mace, Conner J. Massey, Stuart Batterman et autres

ABSTRACT Background Environmental factors, such as air irritants, may play an important role in chronic rhinosinusitis (CRS); however, no studies to date have examined the role of pollen in CRS disease severity. Here, we analyze the effects of pollen exposure on disease‐specific …

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CHANGES IN PULMONARY FUNCTION FOLLOWING ENDOSCOPIC SINUS SURGERY

Elise Krippaehne, Hunter Kellerman, David J. McGee, N. Overbeck et autres

Olfactory Dysfunction and Mental Health Disparities Within a US Population

Sidharth K. Sengupta, Jess C. Mace, Kara Y. Detwiller, Timothy L. Smith et autres

Research continues to uncover the complex relationships between olfactory dysfunction (OD), a condition characterized by either a partial or complete loss of the sense of smell, and various comorbidities and health disparities. Among the disparities seen in OD, associations with mental health …

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