Miharu Ito

Historical evolution of thoracoscopic repair for congenital diaphragmatic hernia: an era-based systematic review and meta-analysis

Masaya Yamoto, Miharu Ito, Kouji Nagata, Yuka Yamamoto et autres

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Refractory Pleural Effusion and Severe Hypotonia in an Extremely Premature Infant With Prader‐Willi Syndrome

Miharu Ito, Yukako Muramatsu, Yohei Takeuchi, Yuki Hashimoto et autres

The authors declare no conflicts of interest. The data that support the findings of this study are available on request from the corresponding author. The data are not publicly available due to privacy or ethical restrictions. Table S1: Pre- and post-treatment laboratory …

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Total hydrocortisone dosage in extremely low birth weight infants and neurodevelopment up to school age

Akinobu Taniguchi, Basile Chrétien, Takashi Maeda, Kazuto Ueda et autres

BACKGROUND: An association between total hydrocortisone (HC) dosage in infants with extremely low birth weight (ELBW) and subsequent neurodevelopmental outcomes up to school age remains unclear. METHOD: We conducted a retrospective longitudinal cohort study across eight centers in Japan, including ELBW infants …

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An Optimal Initial Ventilation Mode in Congenital Diaphragmatic Hernia: A Prospective Cohort Study

Miharu Ito, Satoko Ohfuji, Keita Terui, Kouji Nagata et autres

OBJECTIVES: Respiratory management is crucial for patients with congenital diaphragmatic hernia (CDH). This prospective study aimed to assess the optimal initial ventilatory mode for CDH by comparing conventional mechanical ventilation (CMV) and high-frequency oscillatory ventilation (HFO). METHODS: Fifteen participating institutes used CMV …

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Motor and functional characteristics in school-age survivors of congenital diaphragmatic hernia: a cross-sectional observational study

Takamasa Mitsumatsu, Yuji Ito, Yukako Muramatsu, Yoshiaki Sato et autres

BACKGROUND: Children born with congenital diaphragmatic hernia (CDH) are at risk of poor developmental outcomes. This study aimed to clarify the motor and functional characteristics of school-age CDH survivors and identify perinatal factors associated with motor function deficits. METHODS: Motor function was …

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Isolated congenital diaphragmatic hernia and three-year neurodevelopmental outcomes

Katsuaki Toyoshima, Hirosato Aoki, Kaoru Katsumata, Yoshiaki Sato et autres

BACKGROUND: To retrospectively investigate the developmental outcomes at 3 years of age in patients with congenital diaphragmatic hernia (CDH) using a multicenter collaborative research approach. METHODS: We evaluated patients with CDH and no other malformations born between 2010 and 2016 in seven …

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Safety and tolerability of a Muse cell-based product in neonatal hypoxic-ischemic encephalopathy with therapeutic hypothermia (SHIELD trial)

Yoshiaki Sato, Shinobu Shimizu, Kazuto Ueda, Toshihiko Suzuki et autres

Hypoxic-ischemic encephalopathy (HIE), associated with high mortality and neurological sequelae, lacks established treatment except therapeutic hypothermia. Clinical-grade multilineage-differentiating stress-enduring (Muse) cells (CL2020) demonstrated safety and efficacy in nonclinical HIE rat models, thereby leading to an investigator-initiated clinical trial to evaluate CL2020 safety …

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Total Hydrocortisone Dosage in the Neonatal Period May Be Related to Low Developmental Quotient in Extremely Low Birth Weight Infants: A Retrospective Cohort Study

Akinobu Taniguchi, Kazuki Nishida, Toshihiko Suzuki, Erina Kataoka et autres

INTRODUCTION: The effects of hydrocortisone (HDC) administration to extremely low birth weight (ELBW) infants on later development remain unclear. This study examined the association between HDC dosage during neonatal period and neurodevelopmental outcomes in ELBW infants. METHODS: This study was a retrospective …

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Neonatal outcomes of congenital diaphragmatic hernia in full term versus early term deliveries: A systematic review and meta‐analysis

Kazuya Mimura, Masayuki Endo, Yoko Kawanishi, Takeshi Kanagawa et autres

This systematic review and meta-analysis aimed to review the optimal timing of delivery at term for neonates with prenatally diagnosed congenital diaphragmatic hernia (CDH). We reviewed the literature up to December 19, 2022 using MEDLINE and the Cochrane Library databases. The inclusion …

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Case report: High-dose epoprostenol therapy in pediatric patients with pulmonary hypertension and developmental lung disease

Yoshie Fukasawa, Hidenori Yamamoto, Miharu Ito, Akiko Saito et autres

Pulmonary hypertension (PH) with developmental lung disease is a life-threatening disease and accounts for 10%-12% of pediatric PH patients. Administration of specific pulmonary vasodilators to pediatric PH patients has brought about improvement of their long-term prognosis. Intravenous epoprostenol therapy is a gold …

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5p deletion with congenital diaphragmatic hernia: a case report

Tomomi Kotani, Takafumi Ushida, Noriyuki Nakamura, Kenji Imai et autres

Abstract Background 5p deletion syndrome is known as cri-du-chat syndrome, but there are no reports on congenital diaphragmatic hernia complications associated with it. Case presentation A 28-year-old primigravida Japanese woman was referred for 5 mm of nuchal translucency. Fetal growth restriction was …

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A case of non-immune hydrops fetalis with maternal mirror syndrome diagnosed by trio-based exome sequencing: An autopsy case report and literature review

Sho Tano, Tomomi Kotani, Masato Yoshihara, Noriyuki Nakamura et autres

Non-immune hydrops fetalis (NIHF) indicates the risk for stillbirth. Although the causes vary and most NIHFs have no identifiable cause, recent advances in exome sequencing have increased diagnostic rates. We report a case of NIHF that developed into a giant cystic hygroma …

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