Accès ouvert
2026
article
OpenAlex
Michel Kahi, Abigail Mazzu′, Ludovic Batistic, Marc Pujalte-Martin et autres
Protein synthesis plays a central role in cancer development and progression. eukaryotic initiation factor 5 A (eIF5A), a translation factor activated by hypusination, is implicated in tumorigenesis, however, its mode of action is still unclear. We find that hypusinated eIF5A (eIF5Ahyp) promotes …
fr, nl, in, us
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Accès ouvert
2025
article
OpenAlex
Georgios Efthymiou, E.R.M.A. Lohmann, Claudio Montenegro, Paraskevi Kousteridou et autres
The excessive production of extracellular matrix (ECM) and the metabolic adaptations in pancreatic ductal adenocarcinoma (PDAC) contribute individually to enhanced chemoresistance, marked tumor progression, and dismal patient survival. However, ECM-driven metabolic alterations that promote chemoresistance in PDAC are so far unexplored. Here, …
fr, br, us
(code pays fourni par la source)
Accès ouvert
2025
article
OpenAlex
Lise M. Brault, Edwige Voisset, Mathieu Desaunay, Antonia Boudet et autres
The heterogeneity of leukemic cells is the main cause of resistance to therapy in acute myeloid leukemia (AML). Consequently, innovative therapeutic approaches are critical to target a wide spectrum of leukemic clones, regardless of their genetic and non-genetic complexity. In this report, …
fr, us
(code pays fourni par la source)
Accès ouvert
2025
article
OpenAlex
Celia Sequera, Margherita Grattarola, Floriane Cannet, Aurélie Dobric et autres
Histone deacetylases (HDACs) are epigenetic regulators frequently altered in cancer. Here we report that overexpression of HDAC1/2 occurs in Hepatocellular Carcinoma (HCC) patients, correlating with poor prognosis. We show that romidepsin, a class-I HDAC inhibitor, elicits a combinatorial perturbation of distinct molecular …
fr, us, ch, it
(code pays fourni par la source)
Accès ouvert
2025
article
OpenAlex
Saharnaz Sarlak, D. Marotte, Jessy Sirera, Arthur Karaulic et autres
Dear Editor,In this study, we demonstrated that proton (P) and photon (X) radiotherapies (RT) lead to different molecular changes in triple-negative breast cancer (TNBC) cells.Pirradiated tumours tended to make larger tumours, while X-irradiated ones exhibited increased aggressiveness.Both types of radiation increased gene …
fr
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Accès ouvert
2025
preprint
OpenAlex
Georgios Efthymiou, Coralie Compare, Eugénie Lohmann, Paraskevi Kousteridou et autres
Abstract The excessive production of extracellular matrix (ECM) and the metabolic adaptations in pancreatic ductal adenocarcinoma (PDAC) contribute individually to enhanced chemoresistance, dramatic tumor progression and dismal patient survival. However, ECM-driven metabolic alterations that promote chemoresistance in PDAC are so far unexplored. …
fr, us
(code pays fourni par la source)
Accès ouvert
2021
article
OpenAlex
Julie Agopian, Quentin Da Costa, Quang Vo Nguyen, Giulia Scorrano et autres
Systemic mastocytosis (SM) is a KIT-driven hematopoietic neoplasm characterized by the excessive accumulation of neoplastic mast cells (MCs) in various organs and, mainly, the bone marrow (BM). Multiple genetic and epigenetic mechanisms contribute to the onset and severity of SM. However, little …
fr, us, nl, es
(code pays fourni par la source)