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Amazonian Nanobioeconomy 5.0: A Critical Integrative Review and Conceptual Framework Toward a Just Planetary Transition

Luísa Schuh, Bruno Figueiredo de Souza, Thais Valim, T. Alves et autres

The transition from predatory extractive economies to high-technology systems centered on the standing forest paradigm represents a defining sustainability challenge for the Global South. This integrative review establishes a novel socio-technical and technological architecture, conceptualized as Amazonian Nanobioeconomy 5.0, by critically synthesizing …

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Cell-Type-Specific Immuno-Angiogenic Modulation in Trophoblasts by Curcumin Solid Lipid Nanoparticles

Tathyana Benetis Piau, T. Alves, Lívia Mello Tonnera, Ana Clara Guedes de Souza et autres

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Gadolinium-Doped Cerium Oxide Nanoparticles Embedded in a 3D-Printed System for Antimicrobial Applications

Alexandre Silva Santos, Idejan P. Gross, João Paulo Santos de Carvalho, Emanoel José Ferreira da Conceição et autres

Abstract Gadolinium-doped cerium oxide (GDC) nanoparticles were synthesized, citrate-functionalized, and incorporated into 3D-printed poly(vinyl alcohol) (PVA) systems for antimicrobial applications. Citrate functionalization reduced the hydrodynamic diameter from ∼600 nm to ∼250 nm and increased the zeta potential magnitude from −15 mV to …

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Bacterial Extracellular Vesicles from Chromobacterium subtsugae and Bacillus thuringiensis as Cell-Free Bioinsecticidal Nanocarriers Against the Soybean Pest Euschistus heros

Maria Eduarda Cimi, Daiane Gonzaga Ribeiro, Yasmim Omendes Nascimento, Micaela Cristiane Gomes dos Reis et autres

Abstract Bacterial extracellular vesicles (bEVs) are membrane-enclosed nanoparticles that transport bioactive cargo and mediate interactions between bacteria and their environment. Although bEVs are increasingly recognized as natural delivery systems, their potential application in plant pest biocontrol remains poorly explored. Here, we provide …

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Octyl Gallate Exhibits Trypanocidal Activity Through Trypanothione Reductase Inhibition and Immunomodulation In Vitro

Vanessa Maria Rodrigues de Souza, Airton Lucas Sousa dos Santos, Yasmim Alves Aires Machado, Franciregina Silva Araújo et autres

Background/Objectives: American trypanosomiasis, caused by Trypanosoma cruzi, remains a major public health challenge due to the limited efficacy and adverse effects associated with current treatments. Octyl gallate (OG), a semi-synthetic derivative of gallic acid, has demonstrated promising biological activities, including antiparasitic effects. …

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Chlorophyll-Loaded Castor Oil Nanoemulsions Exhibit Photodynamic Therapy Efficacy Against B16-F10 Melanoma with Low Cytotoxicity Toward HaCaT Keratinocytes

Joabe Lima Araújo, Alexandre Silva Santos, Vitória Regina Miranda Carvalho Silva, Lucas Carvalho dos Santos et autres

Background: Photodynamic therapy (PDT) is a promising minimally invasive approach for melanoma; however, many photosensitizers lose activity in aqueous media due to aggregation-induced quenching effects. Objectives: The aim of this study was to develop and characterize castor oil–based nanoemulsions containing chlorophyll (NFs-Chl) …

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Investigating the emergence of the Brazilian porcupinepox poxvirus in wild Brazilian porcupines (Coendou longicaudatus)

Liz de Albuquerque Cerqueira, Isabel Luana de Macêdo, Davi Emanuel Ribeiro de Sousa, Yasmin Nunes Godoy da Fonseca et autres

Brazilian porcupinepox virus (BPoPV) has been associated with fatal infections in free-ranging Brazilian porcupines (Coendou longicaudatus), raising concerns regarding its epidemiology and conservation impact. This study comprehensively investigates BPoPV infection, pathology, and mortality in a free-living population from the Federal District, Brazil. …

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Leaf traits and extrafloral nectaries: strategies to reduce herbivory in Cerrado woody species

Marina Neves Delgado, Jhonathan Oliveira Silva, Rogério dos Reis Mendonça, Vivivane Evangelista dos Santos Abreu et autres

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Synthesis of Selenium Nanoparticles: Influence of Reaction Parameters on Physicochemical, Morphological, and Biological Properties

Tainá Pereira da Silva Oliveira, Alan Kelbis Oliveira Lima, Talita Pereira Gonçalves, Isadora Florêncio de Souza et autres

Background/Objectives: Optimizing synthesis parameters is essential to ensure the quality and stability of nanostructures. This study aimed to optimize the synthesis of selenium nanoparticles (SeNPs) by chemical reduction, using sodium selenite (Na2SeO3), ascorbic acid (AA), and polyvinyl alcohol (PVA) at different concentrations, …

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The omega-3 DHA induces pyroptosis and mitochondrial dysfunction in ovarian cancer cells via ROS and caspase-1 activation

Gabriel Pasquarelli-do-Nascimento, Sarah Pinho Bezerra, Júlia Perin Manchine, Nathalia Cristina Silva Lago et autres

Ovarian cancer remains one of the most lethal gynecologic malignancies due to late diagnosis, limited treatment options, and frequent chemoresistance. Docosahexaenoic acid (DHA), a long-chain omega-3 polyunsaturated fatty acid, has been associated with anti-tumor effects in various cancer models. Here, we investigated …

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2-Aminothiophene Derivative SB-83 Inhibits Trypanothione Reductase and Modulates Cytokine Production in Trypanosoma cruzi-Infected Cells

Airton Lucas Sousa dos Santos, Vanessa Maria Rodrigues de Souza, Julyanne Maria Saraiva de Sousa, Raiza Raianne Luz Rodrigues et autres

Chagas disease remains a significant neglected tropical disease that predominantly affects vulnerable populations in rural, low-income areas of Latin America. The management of this condition is severely hindered by the limitations of current therapies, which are characterized by substantial toxicity, diminished efficacy …

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Zika Virus Reprograms Microglial Mitochondrial Metabolism to Support Immune Activation and Viral Replication: Omega-3 DHA Counteracts Neuroinflammation and Viral Persistence

Heloísa Antoniella Braz-de-Melo, Fernanda Gomes Lago, Rafael Corrêa, Igor de Oliveira Santos et autres

Microglial cells exhibit crucial metabolic adaptations to maintain neural homeostasis. However, their dysregulated activation during infections can lead to neurotoxicity and contribute to the development of neuroinflammatory disorders. Understanding the physiological and metabolic changes of microglia during immune activation is crucial for …

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