Karin L. Meeker

Bilingualism modulates baseline brain–cognition relationships in aging: Evidence from the HABS-HD cohort

Lihua Xia, Didac Vidal‐Piñeiro, Karin L. Meeker, Richard N. Henson

Bilingualism has been proposed to confer advantages in cognitive aging, yet the neural mechanisms underlying any such advantages remain debated. In a pre-registered analysis of cross-sectional and longitudinal data from elders in the HABS-HD cohort, we asked whether bilingualism is associated with …

cn, no, us, gb (code pays fourni par la source)

Evaluating The Explanatory Value Of Combining Measures Of Physical Function And Physical Activity To Assess Plasma Biomarkers For Alzheimer’s Disease Risk

Gregory Knell, Melissa E. Petersen, Karin L. Meeker, James Hall et autres

us (code pays fourni par la source)

Sociodemographic and comorbidity factors mediate ethno-racial differences in plasma Alzheimer’s disease biomarkers

Karin L. Meeker, Julie K. Wisch, Melissa E. Petersen, James Hall et autres

Ethno-racial disparities in Alzheimer's disease (AD) risk are well-documented, yet mechanisms underlying these differences remain poorly understood. This study investigates plasma AD biomarkers reflective of amyloid, tau, neurodegeneration, and inflammation across Hispanic, non-Hispanic Black/ African American, and non-Hispanic White adults, and examines …

us (code pays fourni par la source)

Bilingualism and Cognitive Aging in Ethnically Diverse Older Adults: Cross-sectional and Longitudinal Evidence from HABS-HD

Richard N. Henson, Kshipra Gurunandan, Karin L. Meeker, Ina Demetriou et autres

Objectives Identifying modifiable factors that shape cognitive aging trajectories is a central goal in aging research. This study examined whether bilingualism is associated with dementia status and longitudinal cognitive decline, and whether associations vary by ethnicity or gender. Methods We analyzed Wave …

Bilingualism and Cognitive Aging in Ethnically Diverse Older Adults: Cross-sectional and Longitudinal Evidence from HABS-HD

Lihua Xia, Kang Ren, Ina Demetriou, Kshipra Gurunandan et autres

ObjectivesIdentifying modifiable factors that shape cognitive aging trajectories is a central goal in aging research. This study examined whether bilingualism is associated with dementia status and longitudinal cognitive decline, and whether associations vary by ethnicity or gender.MethodsWe analyzed Wave 7 data from …

Bilingualism and cognitive aging in ethnically diverse older adults: cross-sectional and longitudinal evidence from Health and Aging Brain Study—Health Disparities

Lihua Xia, Kang Ren, Ina Demetriou, Kshipra Gurunandan et autres

OBJECTIVES: Identifying modifiable factors that shape cognitive aging trajectories is a central goal in aging research. This study examined whether bilingualism is associated with dementia status and longitudinal cognitive decline, and whether associations vary by ethnicity or gender. METHODS: We analyzed Wave …

gb, cn, us (code pays fourni par la source)

Spatiotemporal dynamics of tau extent and load increase in Alzheimer’s disease across four longitudinal cohorts

Arthur C. Macedo, Lydia Trudel, Joseph Therriault, Nesrine Rahmouni et autres

This longitudinal study including four independent cohorts assessed the spatiotemporal dynamics of tau extent and load changes in Alzheimer’s disease using tau positron emission tomography data from 2,459 participants, including 898 followed for up to 7 years. Regional standardized uptake value ratios …

ca, us, de, br, gb, se, cn, fr (code pays fourni par la source)

Evaluation of physical functioning as a marker of brain imaging outcomes in a multiethnic community-based cohort

Gregory Knell, Karin L. Meeker, Zhengyang Zhou, Melissa E. Petersen et autres

BackgroundPhysical functioning (PF) tests are scalable screening tools for neurodegenerative risk that differ by race and ethnicity, reflecting upstream social inequities. Prior work shows that PF relates to Alzheimer's disease blood biomarkers differentially by race and ethnicity, yet it is unclear if …

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Does Bilingualism Protect against Cognitive Decline? Cross-sectional and Longitudinal Evidence from Ethnically Diverse Older Adults

Lihua Xia, Ina Demetriou, Kshipra Gurunandan, Karin L. Meeker et autres

cn, gb, us, no (code pays fourni par la source)

Eligibility for anti‐amyloid treatment in a multiethnic community‐based study

Lydia Trudel, Joseph Therriault, Arthur Macedo, Karin L. Meeker et autres

Abstract Introduction The approval of anti‐amyloid monoclonal antibodies (mAbs), including lecanemab and donanemab, represents a significant advance in disease‐modifying therapies (DMTs) for early Alzheimer's disease (AD). While appropriate use recommendations (AURs) have been established to guide clinical decision‐making, the proportion of individuals …

ca, us (code pays fourni par la source)

Bilingualism Modulates White Matter–Cognition Associations: A Tract-Level Cross-Sectional and Longitudinal Analysis

Lihua Xia, Karin L. Meeker, Kshipra Gurunandan, Richard Henson

Bilingualism has been proposed as a cognitively enriching experience that may influence brain structure and cognitive aging across the lifespan (Xia, Pineiro, et al., 2026; Xia, Ren, et al., 2026). Beyond structural differences, emerging evidence suggests that bilingualism may modulate the relationship …

Preliminary Characterization of Participant‐Level Tau Brain Networks in the Health and Aging Brain Study ‐ Health Disparities HABS‐HD Cohort

Evgeny J. Chumin, Alex N Tinnel, Olaf Sporns, Karin L. Meeker et autres

BACKGROUND: PET neuroimaging is a powerful diagnostic tool that quantifies amyloid and tau accumulation in vivo. Network approaches have been applied to study brain structure and function in Alzheimer's disease (AD), but it has been challenging to estimate participant-level networks from PET …

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