Jiaqing Pang

Characterization of the binding of skeletal muscle myosin to fibrin in trauma

Chih Jen Yang, Amelia A. Rodolf, Joseph P. Garay, Ethan C Kelmser et autres

BACKGROUND: The procoagulant phenotype of skeletal muscle myosin (SkM) includes the promotion of thrombin generation to form fibrin, and subsequent increased resistance of fibrin clots to fibrinolysis. The release of SkM into circulation following localized tissue injury is hypothesized to promote systemic …

us, tw (code pays fourni par la source)

Abstract Fri149: Acylated Toll-Like Receptor Agonists Enhance Platelet Procoagulant Activity in a CD36-Dependent Manner

Vrishank Shivaprakash, Helena Ventosa, Yiheng Zhang, Sandler Jordan et autres

Background: Platelets express pattern recognition receptors (PRRs), including Toll-like receptors (TLRs) and the scavenger receptor CD36, linking innate immunity, inflammation, and thrombosis. Although pathogen- and damage-associated molecular patterns (PAMPs, DAMPs), as well as microbial ligands, are known to activate platelet immune signaling …

us (code pays fourni par la source)

Abstract Fri156: Mitochondrial permeability transition pore is a critical regulator of highly procoagulant platelet phenotypes

Yiheng Zhang, Sandler Jordan, Osamede Owegie, Helena Ventosa et autres

Background: Excessive platelet procoagulant activity, marked by sustained and high-magnitude phosphatidylserine (PS) externalization, promotes pathological thrombosis. While sustained cytosolic Ca 2+ elevation is required for this phenotype, the mitochondrial mechanisms that govern this process remain incompletely defined. The mitochondrial permeability transition pore …

us (code pays fourni par la source)

Molecular basis for inhibition of α-thrombin activity by bacterial lipopolysaccharides

André L. Lira, Katelyn Cherie Drew, R. L. M. Dantas, Jiaqing Pang et autres

Abstract Dysregulation of the coagulation pathway is a hallmark of endotoxemia and Gram-negative sepsis, leading to disseminated intravascular coagulation resulting from aberrant thrombin generation. Bacterial components such as lipopolysaccharides (LPS) have been shown to indirectly contribute to thrombin generation by activating or …

us, br (code pays fourni par la source)

Micropatterning transcriptionally and phenotypically reprograms endothelial cells

Paula Josic Dominovic, Meghan E. Fallon, Jiaqing Pang, Theodora T. Alese et autres

Vascular occlusions are a major cause of cardiovascular disease and require interventions including graft bypass surgery; yet, the development of synthetic vascular grafts remains a challenge due to the inability of synthetic biomaterials to support an anti-immunogenic endothelium. Topographical micropatterning of biophysical …

us (code pays fourni par la source)

Novel small molecule inhibitors of mitochondrial permeability transition pore (mPTP) block platelet procoagulant activity

Yiheng Zhang, Jordan Sandler, Osamede C. Owegie, H A Capell et autres

Abstract Subpopulations of procoagulant platelets expose phosphatidylserine (PS) on their plasma membrane, providing a catalytic surface for thrombin generation and fibrin formation. Platelet PS exposure is critical for coagulation factor assembly in hemostasis; however, dysregulated procoagulant platelet activity underlies pathological thrombus formation. …

us (code pays fourni par la source)

Topographical Micropatterning Transcriptionally Reprograms Endothelial Cells and Phosphorylates Yes-Associated Protein

Paula Josić, Jiaqing Pang, Theodora T. Alese, Deirdre E.J. Anderson et autres

hr, us (code pays fourni par la source)

The physicochemical properties of lipopolysaccharide chemotypes regulate activation of the contact pathway of blood coagulation

André L. Lira, Berk Taskin, Cristina Puy, Ravi S. Keshari et autres

Lipopolysaccharide (LPS) is the primary pathogenic factor in Gram-negative sepsis. While the presence of LPS in the bloodstream during infection is associated with disseminated intravascular coagulation, the mechanistic link between LPS and blood coagulation activation remains ill-defined. The contact pathway of coagulation-a …

us (code pays fourni par la source)

Pharmacological effects of small molecule BCR-ABL tyrosine kinase inhibitors on platelet function

Yiheng Zhang, Chih‐Jen Yang, Alexander R. Melrose, Jiaqing Pang et autres

us (code pays fourni par la source)

AMP dependent protein kinase regulates endothelial heparan sulfate expression in response to an inflammatory stimulus under arterial shear stress

Rick Mathews, Jiaqing Pang, Siddharth A Muralidaran, Caitlin G X King et autres

us (code pays fourni par la source)

Coagulation factor XI regulates endothelial cell permeability and barrier function in vitro and in vivo

Cristina Puy, Samantha A. Moellmer, Jiaqing Pang, Helen H. Vu et autres

ABSTRACT: Loss of endothelial barrier function contributes to the pathophysiology of many inflammatory diseases. Coagulation factor XI (FXI) plays a regulatory role in inflammation. Although activation of FXI increases vascular permeability in vivo, the mechanism by which FXI or its activated form …

us (code pays fourni par la source)

Abstract 140: Exploring Protein Kinase C Theta (PKCθ) Signaling In The Generation Of Procoagulant Platelet: Insights From Phosphoproteomics And Systems Analysis

Yiheng Zheng, Stephanie Reitsma, Sandler Jordan, Özgün Babur et autres

Background: Platelet activation plays a pivotal role in physiological hemostasis and thrombosis. Protein Kinase C theta (PKCθ) isoforms exert significant regulatory influence on platelet activation. While specific PKC family members have well-defined roles in platelet function, the roles of PKCθ remain less …

us (code pays fourni par la source)