Accès ouvert
2026
article
OpenAlex
Cristina Radaelli, Matthew T. Schmitz, Xiao-Ping Liu, Scott Sawchuk et autres
The physiological properties of human and rodent neurons differ, yet the extent to which these differences reflect human specializations is often unclear. Compared with their rodent counterparts, human supragranular pyramidal neurons possess enriched Hyperpolarization-activated Cyclic Nucleotide-gated channel (HCN channel)-dependent intrinsic membrane properties …
us
(code pays fourni par la source)
Accès ouvert
2026
preprint
OpenAlex
Rachel Dalley, Sarah Walling-Bell, Jeremy A. Miller, Femke Waleboer et autres
The human neocortex underlies higher cognition and is the engine of complex thought. Yet our understanding of its neuronal diversity is limited by sparse access to tissue, inconsistent sampling across studies, and a lack of multiple modality data. Although single-cell transcriptomic taxonomies …
us, nl, hu
(code pays fourni par la source)
Accès ouvert
2025
preprint
OpenAlex
Cristina Radaelli, Matthew T. Schmitz, Xiao-Ping Liu, Scott Sawchuk et autres
Abstract The physiological properties of human and rodent neurons differ, yet the extent to which these differences reflect human specializations is often unclear. Compared with their rodent counterparts, human supragranular pyramidal neurons possess enriched HCN-channel-dependent intrinsic membrane properties and a related sensitivity …
us
(code pays fourni par la source)
Accès ouvert
2025
article
OpenAlex
Charles Cobbs, Gregory T. Chesnut, Ayesha A. Shafi
Prostate cancer (PCa) remains a significant public health challenge in the United States, disproportionately affecting African American (AA) men, who face higher incidence rates, more aggressive disease, and elevated mortality compared to Caucasian American (CA) men. This review explores the multifactorial underpinnings …
us
(code pays fourni par la source)
Accès ouvert
2024
conference-abstract
OpenAlex
Tarek Bou Dargham, Zuowei Su, Sergio Piña‐Oviedo, Michael C. Brown et autres
Abstract BACKGROUND Human cytomegalovirus (HCMV) expression in glioblastoma (GBM) has been corroborated by multiple independent laboratories. HCMV genes have been directly linked to GBM cell proliferation, invasion, and angiogenesis. The HCMV tegument protein pp65 has served as a tumor-specific antigen in serial …
us
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Accès ouvert
2024
article
OpenAlex
James H. Park, Parvinder Hothi, Adrián López García de Lomana, Min Pan et autres
Poor prognosis and drug resistance in glioblastoma (GBM) can result from cellular heterogeneity and treatment-induced shifts in phenotypic states of tumor cells, including dedifferentiation into glioma stem-like cells (GSCs). This rare tumorigenic cell subpopulation resists temozolomide, undergoes proneural-to-mesenchymal transition (PMT) to evade …
us, is
(code pays fourni par la source)
Accès ouvert
2024
preprint
OpenAlex
Serdar Turkarslan, Y.-Q. He, Parvinder Hothi, Carl Murie et autres
ABSTRACT Grade IV glioma, formerly known as glioblastoma multiforme (GBM) is the most aggressive and lethal type of brain tumor, and its treatment remains challenging in part due to extensive interpatient heterogeneity in disease driving mechanisms and lack of prognostic and predictive …
us, ru, ch, jp, it
(code pays fourni par la source)
Accès ouvert
2024
preprint
OpenAlex
James H. Park, Parvinder Hothi, Adrián López García de Lomana, Min Pan et autres
Poor prognosis and drug resistance in glioblastoma (GBM) can result from cellular heterogeneity and treatment-induced shifts in phenotypic states of tumor cells, including dedifferentiation into glioma stem-like cells (GSCs). This rare tumorigenic cell subpopulation resists temozolomide, undergoes proneural-to-mesenchymal transition (PMT) to evade …
us, is, au
(code pays fourni par la source)
Accès ouvert
2023
conference-abstract
OpenAlex
Serdar Turkarslan, Yu He, Parvinder Hothi, Carl Murie et autres
Abstract Glioblastoma (GBM) is the most aggressive and lethal type of brain tumor, and its treatment remains challenging due to the complexity of the underlying molecular mechanisms. Here, we present gbmMINER, a causal and mechanistic transcriptional regulatory network model for GBM that …
us
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Accès ouvert
2023
article
OpenAlex
Brian Lee, Rachel Dalley, Jeremy A. Miller, Thomas Chartrand et autres
Human cortex transcriptomic studies have revealed a hierarchical organization of γ-aminobutyric acid-producing (GABAergic) neurons from subclasses to a high diversity of more granular types. Rapid GABAergic neuron viral genetic labeling plus Patch-seq (patch-clamp electrophysiology plus single-cell RNA sequencing) sampling in human brain …
us, hu, dk
(code pays fourni par la source)
Accès ouvert
2023
article
OpenAlex
Thomas Chartrand, Rachel Dalley, Jennie Close, Natalia A. Goriounova et autres
Neocortical layer 1 (L1) is a site of convergence between pyramidal-neuron dendrites and feedback axons where local inhibitory signaling can profoundly shape cortical processing. Evolutionary expansion of human neocortex is marked by distinctive pyramidal neurons with extensive L1 branching, but whether L1 …
us, nl, hu
(code pays fourni par la source)
Accès ouvert
2023
article
OpenAlex
Nelson Johansen, Saroja Somasundaram, Kyle J. Travaglini, Anna Marie Yanny et autres
Single-cell transcriptomic studies have identified a conserved set of neocortical cell types from small postmortem cohorts. We extended these efforts by assessing cell type variation across 75 adult individuals undergoing epilepsy and tumor surgeries. Nearly all nuclei map to one of 125 …
us
(code pays fourni par la source)