Shubhi Srivastava

Pink1-mediated mitophagy in the endothelium releases proteins encoded by mitochondrial DNA and activates neutrophil responses during inflammation

Priyanka Gajwani, L X Wang, Koushik Debnath, Pierina Danos et autres

Eukaryotic mitochondria are characterized by several features that represent vestiges of their prokaryotic ancestry. One such feature is the N-terminal formylation of proteins encoded by mitochondrial DNA that undergo translation by mitochondrial ribosomes. N-formylated proteins are also released by bacteria and trigger …

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Author response: Pink1-mediated mitophagy in the endothelium releases proteins encoded by mitochondrial DNA and activates neutrophil responses during inflammation

Priyanka Gajwani, Li Wang, Koushik Debnath, Pierina Danos-Diaz et autres

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Nanoparticle-boosted myeloid-derived suppressor cell therapy for immune reprogramming in multiple sclerosis

Endong Zhang, Hanan Ahmed Algarni, Luyu Zhang, Chih-Jia Chao et autres

Massive immune cell infiltration and persistent inflammation in the central nervous system (CNS) are key hallmarks of multiple sclerosis. Here, we report a myeloid-derived suppressor cell (MDSC)-based therapeutic strategy, named CNS Immune Targeting Enabled by MDSCs (CITED), which uses surface-decorated MDSCs carrying …

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Abstract 2483 The Mitochondrial Antiviral Signaling (MAVS) Protein Regulates Vascular Immune Signaling and Metabolism During Systemic Inflammation

Shubhi Srivastava, Mark A. Sanborn, Xinhe Wang, Jalees Rehman

Background: Excessive inflammation can severely damage the lung vascular endothelium, leading to life-threatening conditions such as acute lung injury (ALI) or acute respiratory distress syndrome (ARDS). Key pathogenic mechanisms involve widespread inflammatory activation, increased endothelial cell (EC) permeability, and the formation of …

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AI Based Smart Crop Prediction System for Karnataka State

Shubhi Srivastava, Jeroen B. J. Smeets, Rama Bansidhar Dan, L. Yashwanth et autres

This paper introduces Yield Smart- AI Based Smart Crop Prediction System [1],[6] for Karnataka State, a new machine learning and deep learning project designed to optimize agricultural decision-making by predicting the best crops to grow based on selected season and region. The …

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Vascular FLRT2 regulates venous-mediated angiogenic expansion and CNS barriergenesis

Cecília Llaó-Cid, Blanca Peguera, Piotr Kobialka, Linda Decker et autres

Veins have emerged as the origin of all other endothelial cell subtypes needed to expand vascular networks during developmental and pathological neoangiogenesis. Here, we uncover the role of the angioneurin Fibronectin Leucine Rich Transmembrane protein (FLRT) 2 in central nervous system (CNS) …

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Vascular FLRT2 regulates venous-mediated angiogenic expansion and CNS barriergenesis

Cecília Llaó-Cid, Blanca Peguera, Piotr Kobialka, Linda Decker et autres

Abstract Veins have emerged as the origin of all other endothelial cell subtypes needed to expand vascular networks during developmental and pathological neoangiogenesis. Here, we uncover the significant role of the angioneurin Fibronectin Leucine Rich Transmembrane protein (FLRT) 2 in central nervous …

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InsightStream: A Real-Time Perspective on Classroom Environment

Shubhi Srivastava, Abdul Halim Manan, Akshith Krishnan, H B Arvinda et autres

Abstract: Traditionally, understanding classroom environment relies on subjective observations and post-hoc surveys. "Insight Stream" proposes a paradigm shift, offering a real-time, data-driven perspective through machine learning-powered facial emotion detection. This project leverages AI to analyse student facial expressions during class, capturing the …

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Prediction of Covid-19 Disease using Machine-learning-based Models

Abhisek Omkar Prasad, Megha Singh, Pradumn Mishra, Shubhi Srivastava et autres

According to Chinese health officials, almost 250 million people in China may have caught Covid-19 in the first 20 days of December. Due to the Covid-19 pandemic and its global spread, there is a significant impact on our health system and economy, …

Avifaunal Diversity at Sanjay Gandhi Postgraduate Institute of Medical Sciences (SGPGI Campus), Lucknow, Uttar Pradesh, India

Shubhi Srivastava, Ruchira Nigam, Asif Ahmad Siddiqui, Chitra Singh

One of the most crucial ecological markers for assessing the condition of ecosystems is avifaunal diversity. In order to sustain a trophic level in an ecosystem, birds are a vital animal group. Therefore, it is crucial to thoroughly research the ecology and …

Nuclear translocation of mitochondrial dehydrogenases as an adaptive cardioprotective mechanism

Shubhi Srivastava, Priyanka Gajwani, Jordan Jousma, Hiroe Miyamoto et autres

Chemotherapy-induced cardiac damage remains a leading cause of death amongst cancer survivors. Anthracycline-induced cardiotoxicity is mediated by severe mitochondrial injury, but little is known about the mechanisms by which cardiomyocytes adaptively respond to the injury. We observed the translocation of selected mitochondrial …

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Utilization of Karanja Seed Shells as a Sustainable Heterogeneous Catalyst for Biodiesel Production

Pooja Prajapati, Sakshi Shrivastava, Varsha Sharma, Priyanka Srivastava et autres

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