Hidenori Yokoi

A Self-Assembling Peptide Gel as a Vitreous Substitute: A Rabbit Study

Koji Uesugi, Hirokazu Sakaguchi, Yasutaka Hayashida, Ryuhei Hayashi et autres

Purpose: To evaluate a self-assembling peptide gel as a potential vitreous substitute. Methods: PanaceaGel SPG-178, a self-assembling peptide gel, was diluted with distilled water and a balanced salt solution to achieve a final peptide concentration of 0.1%. The gel's refractive index, visible …

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Hierarchical Structure of the Fibrillar Hydrogel Network of a Self‐Assembled Synthetic Peptide Revealed by X‐ray Scattering and Atmospheric Scanning Electron Microscopy

Katsuhiro Yamamoto, Hidenori Yokoi, Aya Otani

Summary We herein developed a self‐assembling peptide with the ability to form a gel in water at pH ∼7 (SPG‐178 (a self‐assembling peptide gel with the amino acid sequence #178; [CH3CO]‐RLDLRLALRLDLR‐[NH2]; R = arginine, L = leucine, D = aspartic acid, and …

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The mechanical stimulation of cells in 3D culture within a self-assembling peptide hydrogel

Yusuke Nagai, Hidenori Yokoi, Keiko Kaihara, Keiji Naruse

The aim of this present study was to provide a scaffold as a tool for the investigation of the effect of mechanical stimulation on three-dimensionally cultured cells. For this purpose, we developed an artificial self-assembling peptide (SPG-178) hydrogel scaffold. The structural properties …

Strategy for Designing Self‐Assembling Peptides to Prepare Transparent Nanofiber Hydrogel at Neutral pH

Hidenori Yokoi, Takatoshi Kinoshita

This study examined the formation of nanofiber hydrogels at neutral pH for 16 types of peptides with different net charges, hydrophobicities, and degrees of polymerization. The peptides formed various hydrogels depending on the arrangement of charged amino acids in the antiparallel β‐sheet …

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The mechanical stimulation of cells in 3D culture within a self-assembling peptide hydrogel

Yusuke Nagai, Hidenori Yokoi, Keiko Kaihara, Keiji Naruse

The aim of this present study was to provide a scaffold as a tool for the investigation of the effect of mechanical stimulation on three-dimensionally cultured cells. For this purpose, we developed an artificial self-assembling peptide (SPG-178) hydrogel scaffold. The structural properties …

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Designer Self-Assembling Peptide Nanofiber Scaffolds

Shuguang Zhang, Hidenori Yokoi, Fabrizio Gelain, Akihiro Horii

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Virus-associated Hemophagocytic Syndrome (VAHS) as an Initial Manifestation in HIV Infection

Keiko Nagaya, Hidenori Yokoi, Yuya Narui, Takuo Haruyama et autres

A 21-year-old man admitted for idiopathic fever and sore throat was diagnosed with virus-associated hemophagocytic syndrome (VAHS) when bone marrow aspirate showed hemophagocytosis. ELISA for HIV antibodies was negative, although HIV RNA was positive. VAHS is extremely rare as an initial manifestation …

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Efficacy of Self-assembled Hydrogels Composed of Positively or Negatively Charged Peptides as Scaffolds for Cell Culture

Aya Nagayasu, Hidenori Yokoi, Jun A. MINAGUCHI, Yoshinao Z. Hosaka et autres

KASEA16(+) and KASEA16(-) peptides, the net charges of which are positive and negative, respectively, under a neutral condition could undergo self-assembly into nanofibers and form transparent hydrogels without peptide aggregation upon rapid pH neutralization. The numbers of NIH3T3 cells attached to the …

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0235 Development of new peptide scaffold for 3-D cell culturing under mechanical stimulation

Yusuke Nagai, Keiko Kaihara, Hidenori Yokoi, Koji Uesugi et autres

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Designer self-assembling peptide nanomaterials

Yang Yanlian, Ulung Khoe, Akihiro Horii, Hidenori Yokoi

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Controlled release and interaction of protein using self‐assembling peptide RATEA16 nanofiber hydrogels

Ying Zhao, Tianwei Tan, Hidenori Yokoi, Masayoshi Tanaka et autres

In this work, we report a new peptide RATEA16 nanofiber hydrogel as a drug delivery system for protein, and the protein-nanofiber assemblies are formed based on hydrophobic and electrostatic interactions. The loading/release process is reversible by changing media pH, and the protein …

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Self-Assembled pH-Responsive Hydrogels Composed of the RATEA16 Peptide

Ying Zhao, Hidenori Yokoi, Masayoshi Tanaka, Takatoshi Kinoshita et autres

Peptide RATEA16 spontaneously self-assembled into higher-order nanofiber hydrogels with extremely high water content (>99.5% (wt/vol)) under physiological condition. The hydrogels could undergo pH-reversible transitions from viscous solution to elastic hydrogel and to precipitate. The supramolecular self-assembly and the three phase transitions are …

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