Benjamin M. Wilson

Disparities Associated With Patient Adherence to BI-RADS 3 Assessment Follow-up Recommendations for Mammography and Ultrasound

Derek L. Nguyen, Benjamin M. Wilson, Eniola T. Oluyemi, Kelly S. Myers et autres

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Generation of a Genome Scale Lentiviral Vector Library for EF1α Promoter-Driven Expression of Human ORFs and Identification of Human Genes Affecting Viral Titer

Dubravka Škalamera, Mareike Dahmer‐Heath, Amy S. Purdon, Benjamin M. Wilson et autres

The bottleneck in elucidating gene function through high-throughput gain-of-function genome screening is the limited availability of comprehensive libraries for gene overexpression. Lentiviral vectors are the most versatile and widely used vehicles for gene expression in mammalian cells. Lentiviral supernatant libraries for genome …

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A Genome-wide Human ORF Gain-of-function Screen to Identify Genes that can Bypass p16INK4a-mediated Cellular Senescence

W. J. Lee, Dubravka Škalamera, Mareike Dahmer‐Heath, K. Shakhbazov et autres

Cellular senescence is a genuine tumour suppressor mechanism. It can be induced by ionising radiation, activated oncogenes and by the p16INK4a tumour suppressor gene, commonly known as p16, which is frequently mutated, deleted or silenced in melanoma and other cancers. Human naevi …

A High-Throughput Platform for Lentiviral Overexpression Screening of the Human ORFeome

Dubravka Škalamera, Max V. Ranall, Benjamin M. Wilson, Paul J. Leo et autres

In response to the growing need for functional analysis of the human genome, we have developed a platform for high-throughput functional screening of genes overexpressed from lentiviral vectors. Protein-coding human open reading frames (ORFs) from the Mammalian Gene Collection were transferred into …

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A functional genomics approach to identify genes and pathways that can bypass p16INK4a-mediated cellular senescence

W. J. Lee, Dubravka Škalamera, Mareike Dahmer‐Heath, K. Shakhbazov et autres

The p16INK4a tumour suppressor gene, commonly known as p16, is frequently mutated, silenced or deleted in melanomas and other solid tumours. It can induce a phenotype known as cellular senescence, which is defined as a state of permanent proliferative arrest despite the …

Spectroscopy and calculations of weakly bound gallium complexes with ammonia and monomethylamine

Shenggang Li, Gretchen K. Rothschopf, Dinesh Pillai, Bradford R. Sohnlein et autres

The gallium complexes were produced in pulsed molecular beams and studied with zero electron kinetic energy (ZEKE) photoelectron spectroscopy. Intermolecular vibrational frequencies and adiabatic ionization potentials (IPs) were obtained from ZEKE spectra. Ground electronic states were identified by combining the ZEKE spectra …

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