Jason Shoush

mTORC1 suppression by Trp53 mutation drives resistance to immune checkpoint blockade

Alireza Labani‐Motlagh, Yang Li, David Shihong Gao, Eunseuk Lee et autres

Abstract p53 is a critical tumor suppressor gene that inhibits cancer development by regulating cell cycle arrest, apoptosis, DNA repair, and metabolism. However, recent studies examining TP53 mutations in cancer immunotherapy have yielded inconsistent results, likely due to differences in t umor …

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mTORC1 Suppression by Trp53 Mutation Drives Resistance to Immune Checkpoint Blockade

Binfeng Lu, Alireza Labani‐Motlagh, Yang Li, David Shihong Gao et autres

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Supplementary Materials from Efficacy of a Small-Molecule Inhibitor of KrasG12D in Immunocompetent Models of Pancreatic Cancer

Samantha B. Kemp, Noah Cheng, Nune Markosyan, Rina Sor et autres

Supplementary Figures and Table with legend arranged in a single presentable package

Supplementary Table from Efficacy of a Small-Molecule Inhibitor of KrasG12D in Immunocompetent Models of Pancreatic Cancer

Samantha B. Kemp, Noah Cheng, Nune Markosyan, Rina Sor et autres

Antibody lists

Supplementary Figure S7 from Efficacy of a Small-Molecule Inhibitor of KrasG12D in Immunocompetent Models of Pancreatic Cancer

Samantha B. Kemp, Noah Cheng, Nune Markosyan, Rina Sor et autres

Effects of MRTX1133 in KPC/Y and subcutaneous models

Supplementary Figure S1 from Efficacy of a Small-Molecule Inhibitor of KrasG12D in Immunocompetent Models of Pancreatic Cancer

Samantha B. Kemp, Noah Cheng, Nune Markosyan, Rina Sor et autres

MRTX1133 selectively inhibits KRASG12D and downstream MAPK signaling in vitro

Supplementary Figure S5 from Efficacy of a Small-Molecule Inhibitor of KrasG12D in Immunocompetent Models of Pancreatic Cancer

Samantha B. Kemp, Noah Cheng, Nune Markosyan, Rina Sor et autres

MRTX1133 exerts in vivo effects early in treatment

Supplementary Figure S4 from Efficacy of a Small-Molecule Inhibitor of KrasG12D in Immunocompetent Models of Pancreatic Cancer

Samantha B. Kemp, Noah Cheng, Nune Markosyan, Rina Sor et autres

MRTX1133 elicits changes in the tumor stroma and vasculature

Supplementary Figure S3 from Efficacy of a Small-Molecule Inhibitor of KrasG12D in Immunocompetent Models of Pancreatic Cancer

Samantha B. Kemp, Noah Cheng, Nune Markosyan, Rina Sor et autres

MRTX1133 reduces metastatic burden in a tail vein model

Supplementary Figure S6 from Efficacy of a Small-Molecule Inhibitor of KrasG12D in Immunocompetent Models of Pancreatic Cancer

Samantha B. Kemp, Noah Cheng, Nune Markosyan, Rina Sor et autres

KRASG12D inhibition alters the tumor immune microenvironment

Glutamine is critical for the maintenance of type 1 conventional dendritic cells in normal tissue and the tumor microenvironment

Graham P. Lobel, Nanumi Han, William A. Molina Arocho, Michal Silber et autres

Proliferating tumor cells take up glutamine for anabolic processes, engendering glutamine deficiency in the tumor microenvironment. How this might impact immune cells is not well understood. Using multiple mouse models of soft tissue sarcomas, glutamine antagonists, as well as genetic and pharmacological …

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900 An iron-rich subset of macrophages promotes tumor growth through a Bach1-Ednrb axis

Ian W. Folkert, William A. Molina Arocho, Tsun Ki Jerrick To, Samir Devalaraja et autres

Background Tumor associated macrophages (TAMs) frequently comprise the most abundant leukocyte population within the tumor microenvironment (TME). TAMs are phenotypically diverse and can be polarized towards either pro- or anti-tumor functions by signals within the TME. While microvascular dysfunction with red blood …

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